ICM students' seminar, Wednesday 12 February 2014, 1.00pm, Room L2.2, 2nd floor, Leech Bldg, Medical School

 

 

 

Institute Research Student Seminars

 

Speakers:  Sadaf Atarod, PhD student (Haematology)

and Salah Abohelaika, PhD student (Pharmacology & Toxicology)

 

Venue: Seminar room L2.2, 2^nd floor, Leech Building, Medical School

Date and time:  Wednesday 12 February 2014 at 1.00pm

 

Sadaf Atarod will present:

 

“MicroRNAs in Graft-Versus-Host Disease”.

 

Identifying and investigating the role of microRNAs in graft-versus-host disease

at the molecular level.

 

Key words:  microRNA, graft-versus-host disease and allogeneic transplantation

_________________________________

Salah Abohelaika will speak on:

 

“The impact of dietary vitamin K on the pharmacological activity of FXa inhibitor rivaroxaban

in man”.

 

The impact of dietary vitamin K on anticoagulation response to warfarin is well established. However, the impact of diet on the pharmacological activity of newer oral anticoagulants is unknown. The impact of dietary vitamin K was evaluated in a group of healthy volunteers with adequate diet and a group of elderly medically stable patients with perceived poor diet. Clotting times and clotting protein activity was measured for each individual over a range of rivaroxaban concentrations ex-vivo. Dietary vitamin K status was established through the use of a validated dietary questionnaire.

 

Keywords:  Novel oral anticoagulants, Rivaroxaban, Vitamin K, Diet, Anticoagulation

 

 

Chair:  Laura Corbett, PhD student (Liver)