Institute Research Student Seminars
Speakers: Rishab Kapoor, PhD student (Transplantation), Dr Rachel Harry, Research Associate and Allison Farnworth, PhD student (Reproductive & Vascular Biology)
Date and time: Wednesday 11 June 2014 at 1.00pm
Rishab Kapoor will present:
"The Effect of Injury on Renal Tubular Cell Phenotype"
Acute kidney injury (AKI) is a rapid loss of function often secondary to systemic disease. AKI commonly occurs when there is a reduction in renal blood flow leading to renal ischemia. This is then followed by reperfusion once blood flow is re-established. In its most extreme form no blood flows to the kidney, but more commonly there is reduced flow as seen in hypotension and hypovolaemia. The term ischaemia reperfusion injury (IRI) is used to describe this type of injury. This project involves studying the mechanisms by which renal IRI results in long-term disease.
Key words: IRI, fibrosis and hypoxia
Dr Rachel Harry will discuss:
"Does monoclonal antibody induced cytokine release increase with Age?"
Therapeutic antibodies are an example of immune modifying therapies which actively harness the patient immune system to mediate their effects. Administration of the first dose of therapeutic antibodies has previously been associated with a potentially fatal side effect termed a first dose-reaction. Ageing is widely acknowledged to result in changes to the immune system which may influence the efficacy and safety of therapeutic antibodies. This study aims to investigate whether monoclonal antibody induced cytokine production is affected by the age of an individual.
Key words: Therapeutic Antibodies, Ageing, Cytokines.
Allison Farnworth will speak on:
"If you can get away with a silver service, why go for a platinum service? Exploring the way in which frontline NHS staff decides when health care quality is "good enough""
Quality in health care is important. It has been suggested NHS frontline staff should play a key role in defending and improving the quality of the services they provide. This qualitative study explores factors which impact on (a) the ways in which health care professionals define quality of care and (b) the extent they are willing to accept quality which they think could/should be better.
Keywords: Health services research, qualitative methodology and health care quality
Chair: Darren Johnson, PhD student (Dermatology)