Tuesday 15 July 2014, 12.30pm
Great Gable Seminar Room, CARU
Speaker: Dr James Edwards, Marie Curie Fellow, University of Oxford
Title: Musculoskeletal Ageing - Targeting longevity mechanisms to preserve skeletal health
There is a universal link between the ageing process and the deterioration of the musculoskeletal system. The loss of bone mass and strength, elevated cartilage and tendon wear and failure, combined with significant muscle weakening and frailty are all features seen within the ageing population and represent significant healthcare challenges worldwide.
Our group is focused upon the identification and manipulation of ageing-related mechanisms to not only explore the potential for increasing lifespan but also to protect against age-related disorders of the musculoskeletal system by improving therapeutic options, surgical procedures and increasing our knowledge of the ageing process in disease pathogenesis
Recent work has focused upon the role of the sirtuin gene family in bone and cartilage biology, the effects of dietary regimes on the skeleton and how the cellular recycling process of autophagy may be dysregulated with age to impact cells of the musculoskeletal system.