Thursday, 19 February 2015

Systems Biology, Psoriasis, Therapeutic Stratification, and PSORT

 

 

 

PI Seminar Series

 

 

Speaker: Professor Nick Reynolds. Professor of Dermatology

 

Venue: Lecture Theatre D, Dental School

 

Date and Time: 19th February 2015 at 1300-14.00

 

Professor Nick Reynolds will present:

 

‘’ Application of systems biology to understanding of psoriasis plaque resolution and therapeutic stratification’’

 

 

Summary:

Despite recent advances in understanding of immune pathogenesis of psoriasis, mechanisms involved in resolution of psoriatic plaques in response to therapy remain poorly defined.  Research using the specific topical treatment dithranol and narrowband UVB phototherapy identified keratinocyte apoptosis as an important potential mechanism in plaque remodelling.  Agent-based systems biology models facilitated quantitative assessment and testing of specific alternative hypotheses.  This paradigm is now being applied to therapeutic stratification of biological therapy in psoriasis (PSORT  http://www.psort.org.uk/)

                                                 

 

Chair: Dr Penny Lovat

 

 

 

 

 

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