tag:blogger.com,1999:blog-48059103511133404992024-02-21T11:32:45.980+00:00MRG NewcastleRheumatology Research, Immunology Research, Rheumatoid Arthritis Research, Osteoarthritis Research, Joint ResearchMRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.comBlogger435125tag:blogger.com,1999:blog-4805910351113340499.post-73238643908504914542020-05-04T09:03:00.001+01:002020-05-04T09:03:09.236+01:00Newcastle Musculoskeletal Research Group<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> Two more papers this month.</div> <div> <div> <div> <div><br> <div> <table width="100%" bgcolor="#CCCCCC"> <tbody> <tr> <td align="center">PubMed Results</td> </tr> </tbody> </table> Items 1 - 2 of 2<br> </div> <br> <div> <table cellpadding="0" cellspacing="5" width="100%"> <tbody> <tr> <td valign="top" nowrap="nowrap" width="10">1.</td> <td valign="top"><a href="https://www.ncbi.nlm.nih.gov/pubmed/32280951">Frequency of biologic switching and the outcomes of switching in children and young people with juvenile idiopathic arthritis: a national cohort study.</a></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">Kearsley-Fleet L, Heaf E, Davies R, Baildam E, Beresford MW, Foster HE, Southwood TR, Thomson W, Hyrich KL; BCRD and BSPAR-ETN study groups.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top"><span class="jrnl" title="The Lancet Rheumatology">Lancet Rheumatol</span>. 2020 Mar 9;2(4):e217-e226. doi: 10.1016/S2665-9913(20)30025-4. eCollection 2020 Apr.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">PMID: 32280951 [PubMed]<span style="color:#985735; font-weight:bold"> Free PMC Article </span></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td><a href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=32280951">Similar articles</a> </td> </tr> </tbody> </table> <table cellpadding="0" cellspacing="5" width="100%"> <tbody> <tr> <td valign="top" nowrap="nowrap" width="10">2.</td> <td valign="top"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31250166">Fatigue in primary Sjögren's syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study.</a></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D; UK Primary Sjögren's Syndrome Registry, Ng WF.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top"><span class="jrnl" title="Rheumatology international">Rheumatol Int</span>. 2019 Nov;39(11):1867-1873. doi: 10.1007/s00296-019-04354-0. Epub 2019 Jun 27.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">PMID: 31250166 [PubMed - indexed for MEDLINE]<span style="color:#985735; font-weight:bold"> Free PMC Article </span></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td><a href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=31250166">Similar articles</a> </td> </tr> </tbody> </table> </div> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-14969831828301955422020-03-02T12:27:00.001+00:002020-03-02T12:27:14.323+00:00Latest Papers from the Musculoskeletal Research Group<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <br> </div> <div> <div id="Signature"> <div> <div> <div> <div> <table width="100%" bgcolor="#CCCCCC"> <tbody> <tr> <td align="center">PubMed Results</td> </tr> </tbody> </table> <br> </div> <br> <div> <table cellpadding="0" cellspacing="5" width="100%"> <tbody> <tr> <td valign="top" nowrap="nowrap" width="10">1.</td> <td valign="top"><a href="https://www.ncbi.nlm.nih.gov/pubmed/32047959">Serum CXCL13 levels are associated with lymphoma risk and lymphoma occurrence in primary Sjögren's syndrome.</a></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">Traianos EY, Locke J, Lendrem D, Bowman S, Hargreaves B, Macrae V; UK primary Sjögren's syndrome registry, Tarn JR, Ng WF.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top"><span class="jrnl" title="Rheumatology international">Rheumatol Int</span>. 2020 Feb 11. doi: 10.1007/s00296-020-04524-5. [Epub ahead of print]</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">PMID: 32047959 [PubMed - as supplied by publisher]</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td><a href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=32047959">Similar articles</a> </td> </tr> </tbody> </table> <table cellpadding="0" cellspacing="5" width="100%"> <tbody> <tr> <td valign="top" nowrap="nowrap" width="10">2.</td> <td valign="top"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31307535">Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.</a></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D'Agostino MA, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Östor A, Raza K, Taylor PC, van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top"><span class="jrnl" title="Trials">Trials</span>. 2019 Jul 15;20(1):429. doi: 10.1186/s13063-019-3403-7.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">PMID: 31307535 [PubMed - indexed for MEDLINE]<span style="color:#985735; font-weight:bold"> Free PMC Article </span></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td><a href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=31307535">Similar articles</a> </td> </tr> </tbody> </table> <table cellpadding="0" cellspacing="5" width="100%"> <tbody> <tr> <td valign="top" nowrap="nowrap" width="10">3.</td> <td valign="top"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30753709">Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.</a></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">Iqbal K, Lendrem DW, Hargreaves B, Isaacs JD, Thompson B, Pratt AG.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top"><span class="jrnl" title="Rheumatology (Oxford, England)">Rheumatology (Oxford)</span>. 2019 Jul 1;58(7):1268-1273. doi: 10.1093/rheumatology/kez008.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">PMID: 30753709 [PubMed - indexed for MEDLINE]</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td><a href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=30753709">Similar articles</a> </td> </tr> </tbody> </table> <table cellpadding="0" cellspacing="5" width="100%"> <tbody> <tr> <td valign="top" nowrap="nowrap" width="10">4.</td> <td valign="top"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30753680">Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.</a></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top"><span class="jrnl" title="Rheumatology (Oxford, England)">Rheumatology (Oxford)</span>. 2019 Jul 1;58(7):1250-1258. doi: 10.1093/rheumatology/kez003.</td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td align="left" valign="top">PMID: 30753680 [PubMed - indexed for MEDLINE]<span style="color:#985735; font-weight:bold"> Free PMC Article </span></td> </tr> <tr> <td align="left" valign="top" width="10"></td> <td><a href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=30753680">Similar articles</a> </td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-53908980987003604242020-02-25T09:32:00.001+00:002020-02-25T09:33:51.528+00:00CXCL13 and lymphoma risk in pSS<div id="Signature">
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MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-71115872998648280322020-02-20T15:10:00.001+00:002020-02-20T15:10:09.012+00:00Tilly Hale Award - Deadline is 20th March<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 32, 96);">More on the Tilly Hale Award to support public engagement and patient involvement in your research. </span></div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 32, 96);"><br> </span></div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 32, 96);">Please see the following link:</span></div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 32, 96);"><br> </span></div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 32, 96);"> </span><a href="https://newcastle.sharepoint.com/hub/medical/news/Pages/engagementfunds.aspx" id="OWA6800e8f2-5cfd-b3a8-501c-00ea1841662a" class="OWAAutoLink">https://newcastle.sharepoint.com/hub/medical/news/Pages/engagementfunds.aspx</a><br> </div> <div id="Signature"> <div> <div class="WordSection1"> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> <span style="color:#002060"> </span></p> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-77622194710250257062020-02-20T10:38:00.001+00:002020-02-20T10:38:35.479+00:00INsTRuCT website is live!<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="font-family: Calibri, sans-serif; font-size: 11pt;">Check out this exciting new network - INsTRuCT is an EU-funded Innnovative Training Network, aiming to train the next generation of researchers in the cellular therapy field. </span></div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <br> </div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span lang="EN-US" style="font-family: Calibri, sans-serif; font-size: 11pt;"><a href="https://www.instruct-h2020.eu/" style="font-family: Calibri, sans-serif; font-size: 11pt;">https://www.instruct-h2020.eu/</a></span><br> </div> <div id="Signature"> <div> <div class="WordSection1"> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> </p> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> <span style="font-family: Calibri, sans-serif; font-size: 11pt;"> </span><br> </p> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> <a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiSBHWXie2bY8FPDBfU0xWRGxcjl-Gmtp_DO-VwZ3jDYX_8kM66xdkQR3T99uQGITQzP0HHaL_NaTIG1CIyvVJ31Q_rBflM6OQU6jXw8aReCgvcUseTKPI8QZ20zQ4GJfkKOAfgVu9fP4aO/s1600/image001-715485.png"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiSBHWXie2bY8FPDBfU0xWRGxcjl-Gmtp_DO-VwZ3jDYX_8kM66xdkQR3T99uQGITQzP0HHaL_NaTIG1CIyvVJ31Q_rBflM6OQU6jXw8aReCgvcUseTKPI8QZ20zQ4GJfkKOAfgVu9fP4aO/s320/image001-715485.png" border="0" alt="" id="BLOGGER_PHOTO_ID_6795476278196951986" /></a></p> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> <br> </p> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-9405668620834322172019-12-03T10:53:00.001+00:002019-12-03T10:53:18.417+00:00MRG November Publications<div style=""><font color="#000000"> <p style="margin: 0cm 0cm 0.0001pt;"><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Featuring Tolergenic dendritic cells, MRI and rituximab for JIA patients.</span></p> <p style="margin: 0cm 0cm 0.0001pt;"><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);"><br> </span></p> <p style="margin: 0cm 0cm 0.0001pt;"><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);"><br> </span></p> <p style="margin: 0cm 0cm 0.0001pt;"><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Spiering R, Jansen MAA, Wood MJ, Fath AA, Eltherington O, Anderson AE, Pratt AG, van Eden W, Isaacs JD, Broere F, Hilkens CMU.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">J Transl Med. 2019 Nov 14;17(1):375. doi: 10.1186/s12967-019-2128-4.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">PMID: 31727095 [PubMed - in process] Free Article</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Similar articles</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);"> </span><br> <font face="Calibri, sans-serif"><span style="font-size: 14.6667px;"><br> </span></font><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Can quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis?</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Bennett JL, Wood A, Smith N, Mistry R, Allen K, Jandial S, Tuckett JD, Gowdy SC, Foster HE, McErlane F, Hollingsworth KG.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Pediatr Rheumatol Online J. 2019 Nov 21;17(1):74. doi: 10.1186/s12969-019-0377-7.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">PMID: 31752877 [PubMed - in process] Free PMC Article</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Similar articles</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);"> </span><br> <font face="Calibri, sans-serif"><span style="font-size: 14.6667px;"><br> </span></font><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Use and effectiveness of rituximab in childre</span><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">n and young people with juvenile idiopathic arthritis in a cohort study in the United Kingdom.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Kearsley-Fleet L, Sampath S, McCann LJ, Baildam E, Beresford MW, Davies R, De Cock D, Foster HE, Southwood TR, Thomson W, Hyrich KL.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Rheumatology (Oxford). 2019 Feb 1;58(2):331-335. doi: 10.1093/rheumatology/key306.</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">PMID: 30358861 [PubMed - indexed for MEDLINE] Free PMC Article</span><br> <span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">Similar articles</span><br> </p> <p style="font-family: Calibri, sans-serif; margin: 0cm 0cm 0.0001pt; font-size: 11pt;"> </p> <p style="font-family: Calibri, sans-serif; margin: 0cm 0cm 0.0001pt; font-size: 11pt;"> </p> <p style="font-family: Calibri, sans-serif; margin: 0cm 0cm 0.0001pt; font-size: 11pt;"> </p> <br> </font></div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-37779202769610535342019-10-30T13:26:00.001+00:002019-10-30T13:26:42.762+00:00Sjogrens Syndrome in the News<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr"> <p style="margin-top:0;margin-bottom:0">See <a href="https://www.ncl.ac.uk/press/articles/latest/2019/10/sjogrensyndromebreakthrough/" class="OWAAutoLink" id="LPlnk270929" previewremoved="true">https://www.ncl.ac.uk/press/articles/latest/2019/10/sjogrensyndromebreakthrough/</a></p> <div id="LPBorder_GT_15724419464420.4549231176422288" style="margin-bottom: 20px; overflow: auto; width: 100%; text-indent: 0px;"> <table id="LPContainer_15724419464400.9405671590612139" role="presentation" cellspacing="0" style="width: 90%; background-color: rgb(255, 255, 255); position: relative; overflow: auto; padding-top: 20px; padding-bottom: 20px; margin-top: 20px; border-top: 1px dotted rgb(200, 200, 200); border-bottom: 1px dotted rgb(200, 200, 200);"> <tbody> <tr valign="top" style="border-spacing: 0px;"> <td id="ImageCell_15724419464410.7804550464955702" colspan="1" style="width: 250px; position: relative; display: table-cell; padding-right: 20px;"> <div id="LPImageContainer_15724419464410.36258893265107783" style="background-color: rgb(255, 255, 255); height: 126px; position: relative; margin: auto; display: table; width: 250px;"> <a id="LPImageAnchor_15724419464410.013366770212162704" href="https://www.ncl.ac.uk/press/articles/latest/2019/10/sjogrensyndromebreakthrough/" target="_blank" style="display: table-cell; text-align: center;"><img id="LPThumbnailImageID_15724419464410.9610684708279351" width="250" height="125" style="display: inline-block; max-width: 250px; max-height: 250px; height: 125px; width: 250px; border-width: 0px; vertical-align: bottom;" src="http://www.ncl.ac.uk/media/wwwnclacuk/pressoffice/images/news/facial-pain-social-media.jpg"></a></div> </td> <td id="TextCell_15724419464410.6327528155397335" colspan="2" style="vertical-align: top; position: relative; padding: 0px; display: table-cell;"> <div id="LPRemovePreviewContainer_15724419464410.691314924069359"></div> <div id="LPTitle_15724419464410.10897040874148334" style="top: 0px; color: rgb(0, 120, 215); font-weight: 400; font-size: 21px; font-family: wf_segoe-ui_light, "Segoe UI Light", "Segoe WP Light", "Segoe UI", "Segoe WP", Tahoma, Arial, sans-serif; line-height: 21px;"> <a id="LPUrlAnchor_15724419464410.03216715303131723" href="https://www.ncl.ac.uk/press/articles/latest/2019/10/sjogrensyndromebreakthrough/" target="_blank" style="text-decoration: none;">Sjögren syndrome breakthrough - Press Office - Newcastle University - ncl.ac.uk</a></div> <div id="LPMetadata_15724419464410.22918047450909929" style="margin: 10px 0px 16px; color: rgb(102, 102, 102); font-weight: 400; font-family: wf_segoe-ui_normal, "Segoe UI", "Segoe WP", Tahoma, Arial, sans-serif; font-size: 14px; line-height: 14px;"> www.ncl.ac.uk</div> <div id="LPDescription_15724419464420.9800717571968942" style="display: block; color: rgb(102, 102, 102); font-weight: 400; font-family: wf_segoe-ui_normal, "Segoe UI", "Segoe WP", Tahoma, Arial, sans-serif; font-size: 14px; line-height: 20px; max-height: 100px; overflow: hidden;"> A new study has shed light on a debilitating autoimmune condition by identifying a number of subtypes of the disease which could lead to personalised treatment for patients. For the first time, scientists at Newcastle University have found there are at least four versions of primary Sjögren's ...</div> </td> </tr> </tbody> </table> </div> <div style="color: rgb(0, 0, 0);"> <div dir="ltr"> <div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)"> <p style="margin:0cm 0cm 0.0001pt; font-size:11pt; font-family:Calibri,sans-serif; color:rgb(32,31,30); background-color:rgb(255,255,255)"> <br> </p> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-56413679497934826572019-10-16T10:19:00.001+01:002019-10-16T10:19:43.260+01:00Synovial Fibroblasts<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr"> <p style="margin-top:0;margin-bottom:0"><br> </p> <div style="color: rgb(0, 0, 0);"> <div lang="EN-GB" link="#0563C1" vlink="#954F72"> <div class="x_WordSection1"> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:14.0pt"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgCtE_iPKTtseb-lwqdzOOVgmUjYNt4QP-dazXefji2Kkwn8kUPrnnp2IvhMh7xY32Q5KAFVghhwSLkm4U9wDd4uav5616Pat2um6a2htSFGCVu4HNCVKc23RWt7drKyYdWZw4HFEDfJQWS/s1600/image001-783267.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgCtE_iPKTtseb-lwqdzOOVgmUjYNt4QP-dazXefji2Kkwn8kUPrnnp2IvhMh7xY32Q5KAFVghhwSLkm4U9wDd4uav5616Pat2um6a2htSFGCVu4HNCVKc23RWt7drKyYdWZw4HFEDfJQWS/s320/image001-783267.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6748328133976264882" /></a></span></b><b><u><span style="font-size:14.0pt"></span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:22.0pt"><span style="text-decoration:none"> </span></span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:18.0pt">Faculty Seminar </span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:18.0pt"><span style="text-decoration:none"> </span></span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:14.0pt">Speaker:</span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:16.0pt">Kirsten Klein</span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:14.0pt">Centre of Experimental Rheumatology, University Hospital Zurich</span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:12.0pt; color:#1F497D"> </span></p> <p class="x_MsoPlainText"><span style="color:#1F497D"> </span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:14.0pt">Venue:</span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:14.0pt">MED.L2.6</span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:14.0pt"> </span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:14.0pt">Date:</span></u></b><span style="font-size:1.0pt; color:black; border:none windowtext 1.0pt; padding:0cm; background:black; layout-grid-mode:line"> </span><b><u><span style="font-size:14.0pt"></span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:14.0pt">Thursday 17<sup>th</sup> October 2019</span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:14.0pt"> </span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:14.0pt">Time:</span></u></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><span style="font-size:14.0pt">11.30 – 12.30</span></p> <p class="x_MsoPlainText"><b> </b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:16.0pt">Kirsten will present: </span></b></p> <p class="x_MsoNormal" align="center" style="text-align:center"><b><i><span style="font-size:12.0pt"> </span></i></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><i><span style="font-size:14.0pt">"Epigenetics of synovial fibroblasts"</span></i></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><i><span style="font-size:14.0pt"> </span></i></b></p> <p class="x_MsoNormal" style="text-autospace:none"><span lang="EN-US">Synovial fibroblasts are the most abundant stromal cells in joints that promote inflammation and drive joint destruction in rheumatoid arthritis. Synovial fibroblasts from different joint localizations exhibit profound differences in their expression profiles, which translate into a joint specific enrichment of arthritis relevant pathways, molecules and functional differences. Epigenetic factors act as intermediaries to link genetic and environmental risk factors to altered gene expression levels in a cell type-specific manner. Epigenetic mechanisms define the positional identity of synovial fibroblasts and underlie their role in persistent inflammation. Interfering with epigenetic modifications and their related epigenetic enzymes have therapeutic potential in rheumatoid arthritis.</span><span lang="EN-US" style="font-size:12.0pt"></span></p> <p class="x_MsoPlainText" align="center" style="text-align:center"> </p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><u><span style="font-size:16.0pt">Chair:</span></u></b><b><span style="font-size:16.0pt"> </span></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:16.0pt">Professor John Isaacs</span></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:16.0pt"> </span></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:16.0pt"> </span></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:16.0pt"> </span></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:16.0pt"> </span></b></p> <p class="x_MsoPlainText" align="center" style="text-align:center"><b><span style="font-size:16.0pt"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZTjUFDYSDMCoKm0sHA-cLXX8ZgciuGrwopkzZrZaKSu0ASyuiVdw8tCNm5eb4S5hUlIS0NntTUEduDqNfilBLn3ofwN5ykQjfScH2Xeg3seYxU-7hV3o06kkFVmpCSRuKo7_b7Jh8V-__/s1600/image002-785675.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZTjUFDYSDMCoKm0sHA-cLXX8ZgciuGrwopkzZrZaKSu0ASyuiVdw8tCNm5eb4S5hUlIS0NntTUEduDqNfilBLn3ofwN5ykQjfScH2Xeg3seYxU-7hV3o06kkFVmpCSRuKo7_b7Jh8V-__/s320/image002-785675.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6748328146338364514" /></a></span></b><b><span style="font-size:16.0pt"></span></b></p> <p class="x_MsoPlainText"> </p> <p class="x_MsoPlainText"><span style=""> </span></p> <p class="x_MsoPlainText"> </p> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-41412268121937453472019-10-11T13:16:00.001+01:002019-10-11T13:16:34.588+01:00PSORT Showcase - 18th November 2019, Royal College of Physicians, London<div id="divtagdefaultwrapper" dir="ltr" style="font-size: 12pt; color: rgb(0, 0, 0); font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols;"> <p style="margin-top:0; margin-bottom:0"><br> </p> <div style="color:rgb(0,0,0)"> <div lang="EN-GB"> <div class="x_WordSection1"> <p class="x_MsoNormal" align="center" style="margin-bottom:15.0pt; text-align:center; line-height:15.0pt; background:white"> <a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiMfeRz_08lx-u2kSVzUNYrdPK3RV3_7GM8F6LSpPFZdhzcmwbxZOHJBXbEQ16gkP9VQXh3x7iL4tf6aBP-SK6csZM9ciLfhEiQjzSIl1_wkt7MXjVPzG26HutRfTMycF11EdepZRV11z3o/s1600/image002-794593.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiMfeRz_08lx-u2kSVzUNYrdPK3RV3_7GM8F6LSpPFZdhzcmwbxZOHJBXbEQ16gkP9VQXh3x7iL4tf6aBP-SK6csZM9ciLfhEiQjzSIl1_wkt7MXjVPzG26HutRfTMycF11EdepZRV11z3o/s320/image002-794593.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6746518288362759618" /></a><span style="font-size:11.5pt; font-family:"Arial",sans-serif; color:black"></span></p> <p class="x_MsoNormal" style="margin-bottom:15.0pt; line-height:15.0pt; background:white"> <span style="font-size:11.5pt; font-family:"Arial",sans-serif; color:black">The PSORT (Psoriasis Stratification to Optimise Relevant Therapy) Stratified Medicine Consortium will host a one day Showcase event at the Royal College of Physicians, London to highlight its progress, achievements and plans for the future.</span><span style="font-size:9.0pt; font-family:"Helvetica",sans-serif; color:black"></span></p> <p class="x_MsoNormal" style="margin-bottom:15.0pt; line-height:15.0pt; background:white"> <span style="font-size:11.5pt; font-family:"Arial",sans-serif; color:black">Formed by dermatologists, industry partners (including pharmaceutical companies), the British Association of Dermatologists and importantly, the Psoriasis Association, PSORT was established to determine whether it could predict which patients with psoriasis would respond best to a particular biologic drug. This, rather than the existing system of "trial and error" prescribing, would allow new treatment plans to be devised that would be personalised to the individual with psoriasis. If successful, such stratification might also achieve cost savings to the NHS and aid the pharmaceutical industry in the development of new drugs for psoriasis.</span><span style="font-size:9.0pt; font-family:"Helvetica",sans-serif; color:black"></span></p> <p class="x_MsoNormal" style="margin-bottom:15.0pt; line-height:15.0pt; background:white"> <span style="font-size:11.5pt; font-family:"Arial",sans-serif; color:black">The Showcase will focus on how the key aspects of our programme have worked together for patient benefit. It will feature invited lectures by leading international speakers (academic, clinical, industry) interspersed amongst updates from scientists and clinicians from the PSORT team. These will be supplemented by a lunchtime poster exhibition. The day concludes with a networking wine reception. </span><span style="font-size:9.0pt; font-family:"Helvetica",sans-serif; color:black"></span></p> <p class="x_MsoNormal" style="margin-bottom:15.0pt; line-height:15.0pt; background:white"> <span style="font-size:11.5pt; font-family:"Arial",sans-serif; color:black">The Showcase is free to attend and is open to the research community, industry, founders and patients alike. </span><span style="font-size:9.0pt; font-family:"Helvetica",sans-serif; color:black"></span></p> <p class="x_MsoNormal" style="margin-bottom:15.0pt; line-height:15.0pt; background:white"> <span style="font-size:11.5pt; font-family:"Arial",sans-serif; color:black">Join us as we discuss how our findings might be of relevance to you. </span><span style="font-size:9.0pt; font-family:"Helvetica",sans-serif; color:black"></span></p> <p class="x_MsoNormal"><span style="font-size:11.5pt; font-family:"Arial",sans-serif">To register, please use the BAD registration link <a href="https://www.eventsforce.net/bad/277/home" id="LPlnk824884" class="OWAAutoLink" previewremoved="true">https://www.eventsforce.net/bad/277/home</a></span><span style="font-size:11.0pt; color:#1F497D"></span></p> <p class="x_MsoNormal"><span style="font-size:11.0pt; color:#1F497D"> </span></p> <div> <p class="x_MsoNormal"><span style="font-size:11.0pt; color:#1F497D"> </span></p> </div> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-76493187616542355852019-09-27T11:58:00.004+01:002019-09-27T11:58:41.638+01:00What Can Patients Tell Us About Sjӧgren's Syndrome?Apparently, they can tell us quite a lot. <br />
<br />
Three international cohorts, two clinical trials including patient reported symptoms, clinical and biological data, proteomics and transcriptomics. <br />
<br />
See the latest paper in <a href="https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(19)30042-6/fulltext" target="_blank">The Lancet Rheumatology</a>.<br />
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<iframe allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/SXgMQ7i7m4c" width="560"></iframe>
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Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-39050095623253725182019-09-26T16:20:00.001+01:002019-09-26T16:20:56.335+01:00Prof Andy Mellor on Immunotherapy for Chronic Diseases<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <br> </div> <div id="Signature"> <div> <div class="WordSection1"> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><u><span style="font-size:18.0pt">PI Seminar Series</span></u></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-family: Calibri, sans-serif; text-align: center;"> <br> </p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><u><span style="font-size:14.0pt">Speaker:</span></u></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-size:16.0pt">Professor Andy Mellor</span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-size:12.0pt"> </span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><u><span style="font-size:14.0pt">Venue:</span></u></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-size:14.0pt">Dental Lecture Theatre E </span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-size:14.0pt"> </span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><u><span style="font-size:14.0pt">Date:</span></u></b><span style="font-size:1.0pt; font-family:"Times New Roman",serif; color:black; border:none windowtext 1.0pt; padding:0cm; background:black; layout-grid-mode:line"> </span><b><u><span style="font-size:14.0pt"></span></u></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-size:14.0pt">Wednesday 2<sup>nd</sup> October 2019</span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-size:14.0pt"> </span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><u><span style="font-size:14.0pt">Time:</span></u></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-size:14.0pt">13:00 – 14:00</span></p> <p class="MsoPlainText" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> <b> </b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><span style="font-size:16.0pt">Andy Mellor </span></b><b><span style="font-size:16.0pt">will present:</span></b></p> <p class="MsoNormal" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><i><span style="font-size:12.0pt"> </span></i></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><i><span style="font-size:14.0pt">"Immunotherapy for chronic diseases: Can we stop the wheels spinning?"</span></i></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><i><span style="font-size:14.0pt"> </span></i></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-family:"Arial",sans-serif">Chronic conditions create huge and growing health care burdens worldwide. Chronic tissue inflammation is a hallmark of many chronic conditions, including cancers, chronic infections, autoimmune cardiovascular and neuro-inflammatory diseases and allergies. Inflammation activates immune cells to incite protective responses against pathogenic organisms. If unresolved, inflammation causes progressive immune dys-function and increased risk of tissue damage and disease. Immune checkpoints discovered in mouse models of cancer offer new insights into the causes and consequences of chronic inflammation and how to manipulate inflammation to modify immune balance for clinical benefit. Our recent work on mouse models of cancer and autoimmune syndromes provides fresh perspectives on how to manipulate the immune system to prevent and treat chronic conditions</span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <span style="font-family:"Arial",sans-serif"> </span></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> </p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><u><span style="font-size:16.0pt">Chair:</span></u></b><b><span style="font-size:16.0pt"> </span></b></p> <p class="MsoPlainText" align="center" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;text-align:center"> <b><span style="font-size:16.0pt">Professor Mark Walker</span></b></p> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> <i><span style="color:#5F5F5F"> </span></i></p> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> <span style="color:black"></span><span style=""></span></p> <p class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> </p> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-13565122878081601982019-09-16T16:04:00.002+01:002019-09-16T16:04:54.720+01:00Lancet Seminar on Sarcopenia<br />
<br />
Check out the Lancet seminar on sarcopenia at https://www.newcastlebrc.nihr.ac.uk/news/publication-of-lancet-seminar-on-sarcopenia/Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-35832270062727790862019-08-05T14:00:00.002+01:002019-08-05T14:00:53.408+01:00Latest MRG Publications<div style="background-color: white; color: #212121; font-family: wf_segoe-ui_normal, "Segoe UI", "Segoe WP", Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
And another batch of publications from the Musculoskeletal Research Group</div>
<br style="background-color: white; color: #212121; font-family: wf_segoe-ui_normal, "Segoe UI", "Segoe WP", Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;" />
<div style="background-color: white; color: #212121; font-family: wf_segoe-ui_normal, "Segoe UI", "Segoe WP", Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
<table cellpadding="0" cellspacing="5" style="width: 100%px;"><tbody>
<tr><td nowrap="nowrap" valign="top" width="10">1.</td><td valign="top"><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed/31365332" rel="noopener noreferrer" target="_blank">A two-phase cohort study of the sleep phenotype within primary Sjögren's syndrome and its clinical correlates.</a></td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">Lewis I, Hackett KL, Ng WF, Ellis J, Newton JL.</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top"><span class="x_jrnl" title="Clinical and experimental rheumatology">Clin Exp Rheumatol</span>. 2019 Jul 15. [Epub ahead of print]</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">PMID: 31365332 [PubMed - as supplied by publisher]</td></tr>
<tr><td align="left" valign="top" width="10"></td><td><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=31365332" rel="noopener noreferrer" target="_blank">Similar articles</a></td></tr>
</tbody></table>
<table cellpadding="0" cellspacing="5" style="width: 100%px;"><tbody>
<tr><td nowrap="nowrap" valign="top" width="10">2.</td><td valign="top"><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed/31333666" rel="noopener noreferrer" target="_blank">IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.</a></td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG.</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top"><span class="x_jrnl" title="Frontiers in immunology">Front Immunol</span>. 2019 Jul 3;10:1535. doi: 10.3389/fimmu.2019.01535. eCollection 2019.</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">PMID: 31333666 [PubMed - in process]<span style="color: #985735; font-weight: bold;"> Free PMC Article</span></td></tr>
<tr><td align="left" valign="top" width="10"></td><td><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=31333666" rel="noopener noreferrer" target="_blank">Similar articles</a></td></tr>
</tbody></table>
<table cellpadding="0" cellspacing="5" style="width: 100%px;"><tbody>
<tr><td nowrap="nowrap" valign="top" width="10">3.</td><td valign="top"><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed/31307535" rel="noopener noreferrer" target="_blank">Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.</a></td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D'Agostino MA, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Östor A, Raza K, Taylor PC, van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP.</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top"><span class="x_jrnl" title="Trials">Trials</span>. 2019 Jul 15;20(1):429. doi: 10.1186/s13063-019-3403-7.</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">PMID: 31307535 [PubMed - in process]<span style="color: #985735; font-weight: bold;"> Free PMC Article</span></td></tr>
<tr><td align="left" valign="top" width="10"></td><td><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=31307535" rel="noopener noreferrer" target="_blank">Similar articles</a></td></tr>
</tbody></table>
<table cellpadding="0" cellspacing="5" style="width: 100%px;"><tbody>
<tr><td nowrap="nowrap" valign="top" width="10">4.</td><td valign="top"><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed/31280933" rel="noopener noreferrer" target="_blank">Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.</a></td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">Baker KF, Skelton AJ, Lendrem DW, Scadeng A, Thompson B, Pratt AG, Isaacs JD.</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top"><span class="x_jrnl" title="Journal of autoimmunity">J Autoimmun</span>. 2019 Jul 4. pii: S0896-8411(19)30196-9. doi: 10.1016/j.jaut.2019.06.009. [Epub ahead of print]</td></tr>
<tr><td align="left" valign="top" width="10"></td><td align="left" valign="top">PMID: 31280933 [PubMed - as supplied by publisher]<span style="color: #985735; font-weight: bold;"> Free Article</span></td></tr>
<tr><td align="left" valign="top" width="10"></td><td><a data-auth="NotApplicable" href="https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=31280933" rel="noopener noreferrer" target="_blank">Similar articles</a></td></tr>
</tbody></table>
</div>
Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-45778279757128004072019-05-20T13:18:00.001+01:002019-05-20T13:18:33.438+01:00TODAY - SEMINAR<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr"> <p style="margin-top:0;margin-bottom:0">Including Nicola Smith on Paediatric Musculoskeletal Care...</p> <div id="Signature"> <div id="divtagdefaultwrapper" style="color: rgb(0, 0, 0); font-family: Calibri, Arial, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 12pt; background-color: rgb(255, 255, 255);"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <p><br> </p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div style="color: rgb(0, 0, 0);"> <div id="divRplyFwdMsg" dir="ltr"> <div> </div> </div> <div lang="EN-GB" link="#0563C1" vlink="#954F72"> <div class="x_WordSection1"> <p class="x_MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt; font-family:"Times New Roman",serif"> </span></p> <p class="x_MsoNormal" style="margin-left:5.0pt; text-autospace:none"><span style="font-size:10.0pt; font-family:"Times New Roman",serif"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhod-u72ZCI0_KgqG8CvCEJYyerRFLTL12gB58uP-FPjeG9vDzvpsdNPbW2NHCs4XMDyabvDZZ6kIiPlsEqgTngFRj-fmPAnAptU1jkTP2Dr5aFZDN9B92U0v7PuMrxG4NSp_Vcm0mfj2IC/s1600/image001-713448.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhod-u72ZCI0_KgqG8CvCEJYyerRFLTL12gB58uP-FPjeG9vDzvpsdNPbW2NHCs4XMDyabvDZZ6kIiPlsEqgTngFRj-fmPAnAptU1jkTP2Dr5aFZDN9B92U0v7PuMrxG4NSp_Vcm0mfj2IC/s320/image001-713448.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6693082529383710898" /></a></span><span style="font-size:10.0pt; font-family:"Times New Roman",serif"></span></p> <p class="x_MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt; font-family:"Times New Roman",serif"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:9.85pt; margin-bottom:0cm; margin-left:8.7pt; margin-bottom:.0001pt; text-align:center; line-height:25.4pt; text-autospace:none"> <b><span style="font-size:22.0pt">ICM Research in Progress Seminar</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:9.7pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:18.0pt">Monday 20</span></b><b><span style="font-size:11.5pt; top:-6.0pt">th </span></b><b><span style="font-size:18.0pt">May</span></b></p> <p class="x_MsoNormal" style="margin-top:.5pt; text-autospace:none"><b><span style="font-size:19.0pt"> </span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:9.65pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:18.0pt">Anastasia Resteu</span></b></p> <p class="x_MsoNormal" style="margin-right:0cm; margin-bottom:0cm; margin-left:102.9pt; margin-bottom:.0001pt; text-autospace:none"> <span style="font-size:14.0pt">(Dr Venetia Bigley, Prof Matthew Collin, Dr Roman Bauer)</span></p> <p class="x_MsoNormal" align="center" style="margin-right:9.7pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; line-height:106%; text-autospace:none"> <b><span style="font-size:16.0pt; line-height:106%">Differential IRF8 requirement defines two pathways of dendritic cell development in vivo</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:6.95pt; margin-bottom:0cm; margin-left:5.95pt; margin-bottom:.0001pt; text-align:center; text-indent:.05pt; line-height:106%; text-autospace:none"> <span style="font-size:12.0pt; line-height:106%">Dendritic cells (DCs) are specialised antigen-processing and presenting cells with critical roles in the regulation of immunity. Human DC subsets develop in the bone marrow under the control of specific transcription factors, mutation of which can result in dendritic cell immunodeficiency in humans. However, how human DCs develop from haematopoietic stem cells is not well mapped.</span></p> <p class="x_MsoNormal" align="center" style="margin-right:9.3pt; margin-bottom:0cm; margin-left:8.2pt; margin-bottom:.0001pt; text-align:center; text-indent:.1pt; line-height:106%; text-autospace:none"> <span style="font-size:12.0pt; line-height:106%">Single cell transcriptomics, combined with phenotyping and in vitro culture of healthy controls were used to define two distinct pathways of DC development. Their differential requirement for transcription factor IRF8 was interrogated through the analysis of a unique series of patients with IRF8 mutations.</span></p> <p class="x_MsoNormal" style="margin-top:.1pt; text-autospace:none"><span style="font-size:13.0pt"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:9.7pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:18.0pt">Nicola Smith</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:9.5pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <span style="font-size:14.0pt">(Prof Helen Foster)</span></p> <p class="x_MsoNormal" align="center" style="margin-right:9.55pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; line-height:106%; text-autospace:none"> <b><span style="font-size:16.0pt; line-height:106%">Evaluation of Educational Resources Designed to Facilitate Access to Care for Children with Musculoskeletal Conditions</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:9.85pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; line-height:106%; text-autospace:none"> <span style="font-size:12.0pt; line-height:106%">Children with musculoskeletal diseases have a delay in access to specialist care, with impact on quality of life, development and long term outcomes. If we are to achieve our goal of raising awareness and early recognition of rheumatic disease in childhood through education, we need to understand if, and how, our e-resources lead to change in clinical practice. Our work focuses on developing and piloting an evaluation strategy of the e-resources in real-time, across the stakeholder groups, in order to allow iterative development, optimise uptake and gain insights on impact.</span></p> <p class="x_MsoNormal" style="margin-top:.15pt; text-autospace:none"><span style="font-size:13.0pt"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:147.7pt; margin-bottom:0cm; margin-left:146.8pt; margin-bottom:.0001pt; text-align:center; line-height:115%; text-autospace:none"> <b><span style="font-size:18.0pt; line-height:115%">Chair: Henrique De Paula Lemos Dental Lecture Theatre D</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:9.55pt; margin-bottom:0cm; margin-left:8.8pt; margin-bottom:.0001pt; text-align:center; line-height:21.9pt; text-autospace:none"> <b><span style="font-size:18.0pt">1pm - 2pm</span></b></p> <p class="x_MsoNormal" style="margin-bottom:.05pt; text-autospace:none"><b><span style="font-size:10.0pt"> </span></b></p> <p class="x_MsoNormal"></p> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-72151688358470895782019-05-09T11:35:00.001+01:002019-05-09T11:35:24.020+01:00Professor Isaacs' Big Day<p class="mobile-photo"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjo_Ts3CEpaRihLWMCE7A8d09NA2ThhDLxi8eQTbHaF_BQM9k7PmGckaT9KavGDlT1_0cDsjmonCiPBQ54ykBRqff4RM-OWTEGjT_-5k6xS-9xmkLo1Kr9-T-Q1swky3ZFrUAZFA5nYkkSG/s1600/20190509_104459-724030.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjo_Ts3CEpaRihLWMCE7A8d09NA2ThhDLxi8eQTbHaF_BQM9k7PmGckaT9KavGDlT1_0cDsjmonCiPBQ54ykBRqff4RM-OWTEGjT_-5k6xS-9xmkLo1Kr9-T-Q1swky3ZFrUAZFA5nYkkSG/s320/20190509_104459-724030.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6688974012249345058" /></a></p>MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-54801455583266914252019-04-01T12:21:00.002+01:002019-04-01T12:21:40.609+01:00NIHR Trial of Pediatric ToolsHere it is! <br />
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As featured in the NIHR Newsletter - the <a href="https://sites.google.com/nihr.ac.uk/newsroomnenc/archive/archive-2019/march/pgalsplus-study" target="_blank">pgalsplus</a> trial.Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-50425109841387542732019-03-27T13:42:00.002+00:002019-04-09T11:59:53.023+01:00Public and Patient Involvement at Newcastle"Studies designed with patients and the public involved from the beginning are much more likely to have a positive impact in the long run."<br />
<br />
<br />
<iframe allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/N3hWSgnsqi4" width="560"></iframe>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-77309972815574431822019-03-18T15:20:00.001+00:002019-03-18T15:20:04.690+00:00FATIGUE: My Life, Your Research<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> </div> <p align="center" style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; text-align: center; margin: 0px"> <b><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; color: rgb(153, 0, 0);">Registration is now open!</span></b></p> <p align="center" style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; text-align: center; margin-bottom: 0px; margin-left: 4pt"> <b><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: rgb(153, 0, 0); font-size: 12pt;">Fatigue: My life, your research</span></b></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin: 0px"> <span style="margin: 0px"><span style="margin: 0px; color: rgb(80, 0, 80); font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"> </span></span></p> <p align="center" style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; text-align: center; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px"><b><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">Date</span></b></span><b><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">: Wednesday 3 April 2019</span></b></p> <p align="center" style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; text-align: center; margin-bottom: 0px; margin-left: 4pt"> <b><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">Venue: Grainger Suite, Life Science Centre, Times Square, Newcastle upon Tyne, NE1 4EP</span><span style="margin: 0px; font-family: Arial, sans-serif, serif, EmojiFont; color: black"><br> </span><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">Time: 11:00-15:00 (Registration from 10:30-11:00)</span></b></p> <p align="center" style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; text-align: center; margin-bottom: 0px; margin-left: 4pt"> <b><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">Refreshments will be provided</span></b></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin: 0px"> <span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"> </span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">NIHR Clinical Research Network North East and North Cumbria is organising an event on Fatigue Research.</span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"> </span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">We aim to raise awareness of fatigue and explore how it affects many different conditions. In partnership with patients, we will discuss ways to develop new research studies to increase opportunities for patient and public involvement in fatigue research across our region.</span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin: 0px"> <span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"> </span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin: 0px"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">The event is free and open to patients, carers, GPs and researchers who have an interest in Fatigue research. </span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin: 0px"> <span style="margin: 0px"><span style="margin: 0px; color: rgb(80, 0, 80); font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"> </span></span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <b><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">Our aims:</span></b></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">● Learn about current research taking place in fatigue across the region.</span><span style="margin: 0px; color: rgb(80, 0, 80)"></span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">● Hear from patients living with fatigue and the impact it has on their lives.</span><span style="margin: 0px; color: rgb(80, 0, 80)"></span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">● Share your views and take part in discussions to define what we mean by fatigue.</span><span style="margin: 0px; color: rgb(80, 0, 80)"></span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">● Explore how we can develop new research studies in fatigue.</span><span style="margin: 0px; color: rgb(80, 0, 80)"></span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;">● Discover the support and resources available around the region in our marketplace.</span><span style="margin: 0px; color: rgb(80, 0, 80)"></span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 0px; margin-left: 4pt"> <span style="margin: 0px; color: rgb(80, 0, 80); font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"> </span></p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin: 0px"> <span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"><b>The event is free but please register a place: </b></span><a href="https://nencfatigue.eventbrite.co.uk/" target="_blank" rel="noopener noreferrer" style="margin: 0px"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;">https://nencfatigue.eventbrite.co.uk</span></a><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"> </span> </p> <p style="color: rgb(51, 51, 51); background-color: rgb(255, 255, 255); font-size: 12pt; font-family: "Times New Roman", serif; margin: 0px"> </p> <div id="signature"> <div id="divtagdefaultwrapper" style="color:rgb(0,0,0); font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; background-color:rgb(255,255,255)"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <p style="margin-top: 0px; margin-bottom: 0px;"><font size="2"><a class="OWAAutoLink" href="https://www.linkedin.com/in/dennislendrem"></a></font></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-42349697015518574972019-03-12T14:16:00.001+00:002019-03-12T14:16:04.110+00:00Understanding biology at omics and structural levels<blockquote style="margin: 0 0 0 40px; border: none; padding: 0px;"> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 0, 0); font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt;">Thursday 14th March in L2.4 </span></div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 0, 0); font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt;"><span style="color: rgb(51, 51, 51); font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 14.6667px; background-color: rgb(255, 255, 255); display: inline !important">Understanding Biology at omics and structural levels</span></span></div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="color: rgb(0, 0, 0); font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt;">Dr Chichau Miau, Cambridge</span></div> </blockquote> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <br> </div> <div id="signature"> <div><font size="2"><span style="font-size:11pt;"> <div class="PlainText">The talk entitled "Understanding Biology at omics and structural levels" will cover some research work in single cell RNA-seq and computational structural biology. The single cell RNA-seq studies, which are parts of the Human Cell Atlas project, include understanding the sequencing platform, using artificial intelligence to correct the error in single cell experiments and an automatic cell type related clustering method. In addition, an application to the liver cell analysis will demonstrate how to understand the cell to cell variability, cell-cell interaction and cell development using single cell RNA-seq. The computational structural biology part will introduce RNA-Puzzles, which is a world-wide contest in RNA 3D structure prediction, and protein structure/function prediction.<br> </div> </span></font></div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-80425260725722541332019-02-12T09:35:00.001+00:002019-02-12T09:35:22.490+00:00III theme meeting Friday 15th February 9:15 Baddiley Clark seminar room<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <span style="font-family: Calibri, sans-serif; font-size: 11pt;">Our next III Theme meeting will take place on</span><b style="font-family: Calibri, sans-serif; font-size: 11pt; color: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; background-color: ;"> Friday 15<sup>th</sup> February at 9:15-10:45 am </b><span style="font-family: Calibri, sans-serif; font-size: 11pt;">in the Baddiley-Clark seminar room.</span><br> </div> <div id="signature"> <div> <div class="WordSection1"> <p class="MsoPlainText" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> </p> <p class="MsoPlainText" style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;"> Marie-Helene Ruchaud-Sparagano from John Simpson's group and Arthur Pratt will discuss their current research (30 minute each).</p> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-45922310389610986512019-02-04T17:18:00.001+00:002019-02-04T17:18:16.542+00:00Steve Eyre - "RA - post GWAS. <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> Steve Eyre from Manchester is giving tomorrow's IGM seminar at 1 PM about "RA - post GWAS. </div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <br> </div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <a href="https://www.research.manchester.ac.uk/portal/steve.eyre.html">https://www.research.manchester.ac.uk/portal/steve.eyre.html</a><br> </div> <div id="signature"> <div><font size="2"><span style="font-size:11pt;"> <div class="PlainText"><br> Biography<br> I have been involved in researching the genetic susceptibility to rheumatoid arthritis (RA) since I joined the Arthritis Research Centre of Excellence, based at the University of Manchester, UK in 1996. Initially focussing on linkage studies using the large collection of family samples collected at the Centre as part of the National Repository, I quickly moved onto genome wide association studies (GWAS), as part of the Wellcome Trust Case Control Consortium (WTCCC), before leading on the fine-mapping of RA loci in the Immunochip study (Nature Genetics, 2012). This study used over 27,000 samples and led to the discovery of 14 new RA susceptibility loci. In recent years my lab has focussed on understanding the mechanisms by which these DNA variants lead to an increase risk of disease. In collaboration with Peter Fraser (Babraham, Cambridge) and Chris Wallace (University of Cambridge), my group has developed methods to interrogate the regions that are associated with RA, mainly regulatory enhancer regions, to determine the interacting gene targets. Using this Capture HiC methodology we are discovering how long range interactions, often involving multiple regions associated with different autoimmune diseases, regulate gene expression. In addition I have established collaborations with Soumya Raychaudhuri (Harvard Medical School, Boston), Caroline Ospelt (Zurich) and David Sansom (UCL), to look at the immunological, epigenetic and non-coding RNA consequences of the RA associated regions. These methods include ChIP, ATAC-Seq, RNA-seq and CRISPR genome editing.<br> <br> <br> <br> </div> </span></font></div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-71153161619134431182019-02-04T13:56:00.001+00:002019-02-04T13:56:17.224+00:00NF-κB Transcription Factors in B-Cell Lymphomagenesis<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <p align="center" style="margin: 0cm 39.55pt 0.0001pt 41.4pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center"> <b><u><span style="margin: 0px; font-size: 22pt">PI Seminar Series</span></u></b><b><span style="margin: 0px; font-size: 22pt"></span></b></p> <p style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255)"> <b><span style="margin: 0px; font-size: 10pt"> </span></b></p> <p align="center" style="margin: 0cm 39.4pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.35pt"> <b><u><span style="margin: 0px; font-size: 18pt">Speaker:</span></u></b><b><span style="margin: 0px; font-size: 18pt"></span></b></p> <p align="center" style="margin: 0cm 39.55pt 0.0001pt 41.4pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.95pt"> <span style="margin: 0px; font-size: 18pt">Ulf Klein</span></p> <p align="center" style="margin: 0cm 39.35pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center"> <span style="margin: 0px; font-size: 18pt">Professor of Immunology and Haemato-oncology Experimental Haematology,</span></p> <p align="center" style="margin: 0cm 39.45pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.95pt"> <span style="margin: 0px; font-size: 18pt">St. James's University Hospital, University of Leeds</span></p> <p align="center" style="margin: 0cm 39.4pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.95pt"> <b><u><span style="margin: 0px; font-size: 18pt">Venue:</span></u></b><b><span style="margin: 0px; font-size: 18pt"></span></b></p> <p align="center" style="margin: 0cm 39.4pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.95pt"> <span style="margin: 0px; font-size: 18pt">Dental Lecture Theatre F</span></p> <p align="center" style="margin: 0cm 39.55pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.95pt"> <b><u><span style="margin: 0px; font-size: 18pt">Date:</span></u></b><b><span style="margin: 0px; font-size: 18pt"></span></b></p> <p align="center" style="margin: 0cm 39.55pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.95pt"> <span style="margin: 0px; font-size: 18pt">Wednesday 6</span><span style="margin: 0px; font-size: 11.5pt; top: -6pt">th<span> </span></span><span style="margin: 0px; font-size: 18pt">February 2019</span></p> <p align="center" style="margin: 0cm 39.55pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center"> <b><u><span style="margin: 0px; font-size: 18pt">Time:</span></u></b><b><span style="margin: 0px; font-size: 18pt"></span></b></p> <p align="center" style="margin: 0cm 39.45pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center"> <span style="margin: 0px; font-size: 18pt">13:00 – 14:00</span></p> <p style="margin: 0.4pt 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255)"> <span style="margin: 0px; font-size: 13.5pt"> </span></p> <p align="center" style="margin: 0cm 39.35pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center"> <b><span style="margin: 0px; font-size: 20pt">Prof Ulf Klein will present:</span></b></p> <p style="margin: 0.05pt 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255)"> <b><span style="margin: 0px; font-size: 16pt"> </span></b></p> <p align="center" style="margin: 0cm 39.55pt 0.0001pt 41.45pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center; line-height: 21.95pt"> <b><i><span style="margin: 0px; font-size: 18pt">NF-κB Transcription Factors in B-Cell Lymphomagenesis</span></i></b></p> <p align="center" style="margin: 0cm 5.75pt 0.0001pt 7.85pt; font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(33, 33, 33); background-color: rgb(255, 255, 255); text-align: center"> <span style="margin: 0px; font-size: 14pt">Professor Klein has been working on the molecular basis of B-cell development and lymphomagenesis throughout his career. Following his PhD at the University of Cologne, he moved to Columbia University where he was promoted to Associate Professor in 2016. In 2017, he joined the University of Leeds, where he continues his work on elucidating the oncogenic mechanisms that cause malignant transformation of B cells. Currently, a main focus of his lab lies on understanding the roles of the individual NF-κB transcription factor subunits in this process.</span></p> <br> </div> <div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> <br> </div> <div id="signature"> <div id="divtagdefaultwrapper" style="color:rgb(0,0,0); font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; background-color:rgb(255,255,255)"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div><br> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-50775418832258084542019-01-30T11:30:00.001+00:002019-01-30T11:30:45.781+00:00"Finding the genes that are important in rheumatoid arthritis post-GWAS"<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr"> <p style="margin-top:0;margin-bottom:0"><span style="color: rgb(0, 120, 215); font-family: wf_segoe-ui_normal, "Segoe UI", "Segoe WP", Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 14.6667px;">Stephen Eyre from Manchester is giving a talk at the IGM at 1 pm on Tuesday 5th February, Biomedicine West Wing Lecture Theatre.</span></p> <div> <div id="Signature"> <div id="divtagdefaultwrapper" style="color: rgb(0, 0, 0); font-family: Calibri, Arial, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 12pt; background-color: rgb(255, 255, 255);"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <p><font size="2"><a class="OWAAutoLink" href="https://www.linkedin.com/in/dennislendrem" id="LPNoLP"></a></font></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-86660195187470305202018-12-11T15:58:00.000+00:002018-12-11T16:00:45.906+00:00Dr Arthur Pratt - Wednesday 12th December - Dental Lecture Theatre D - 1-2pm<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr"> <p style="margin-top:0;margin-bottom:0"><span style="font-family: "Times New Roman", serif; font-size: 10pt;"> </span><br> </p> <div style="color: rgb(0, 0, 0);"> <div lang="EN-GB" link="#0563C1" vlink="#954F72"> <div class="x_WordSection1"> <p class="x_MsoNormal" align="center" style="margin-left:23.6pt; text-align:center; text-autospace:none"> <span style="font-size:10.0pt; font-family:"Times New Roman",serif"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjd3SvX-Yz44NKfCMjQw4N_1ZQU_kMC8-dRCwz2mDYGQswm6lptl5D9_AqO8uP9chGC7aq8EsUNUKQu2ax8xmCr6VWkJM8OLsIgb3I4eLX6KiSZHjsdHWtYF-HtI9KfaBnaKZ9NhQS46NXO/s1600/image001-745915.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjd3SvX-Yz44NKfCMjQw4N_1ZQU_kMC8-dRCwz2mDYGQswm6lptl5D9_AqO8uP9chGC7aq8EsUNUKQu2ax8xmCr6VWkJM8OLsIgb3I4eLX6KiSZHjsdHWtYF-HtI9KfaBnaKZ9NhQS46NXO/s320/image001-745915.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6633766165929283490" /></a></span><span style="font-size:10.0pt; font-family:"Times New Roman",serif"></span></p> <p class="x_MsoNormal" align="center" style="text-align:center; text-autospace:none"> <span style="font-size:10.0pt; font-family:"Times New Roman",serif"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.7pt; margin-bottom:.0001pt; text-align:center; line-height:23.45pt; text-autospace:none"> <b><u><span style="font-size:20.0pt">PI Seminar Series</span></u></b><b><span style="font-size:20.0pt"></span></b></p> <p class="x_MsoNormal" align="center" style="text-align:center; text-autospace:none"> <b><span style="font-size:10.0pt"> </span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.55pt; margin-bottom:.0001pt; text-align:center; line-height:19.25pt; text-autospace:none"> <b><u><span style="font-size:16.0pt">Speaker:</span></u></b><b><span style="font-size:16.0pt"></span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:24.65pt; margin-bottom:0cm; margin-left:27.75pt; margin-bottom:.0001pt; text-align:center; line-height:19.5pt; text-autospace:none"> <span style="font-size:16.0pt">Dr Arthur Pratt - Intermediate Clinical Fellow/Hon Consult</span></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.6pt; margin-bottom:.0001pt; text-align:center; line-height:19.5pt; text-autospace:none"> <b><u><span style="font-size:16.0pt">Venue:</span></u></b><b><span style="font-size:16.0pt"></span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.6pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <span style="font-size:16.0pt">Dental Lecture Theatre D</span></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.6pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><u><span style="font-size:16.0pt">Date:</span></u></b><b><span style="font-size:16.0pt"></span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.6pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <span style="font-size:16.0pt">Wednesday 12</span><span style="font-size:10.5pt; top:-5.0pt">th </span><span style="font-size:16.0pt">December 2018</span></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.7pt; margin-bottom:.0001pt; text-align:center; line-height:19.5pt; text-autospace:none"> <b><u><span style="font-size:16.0pt">Time:</span></u></b><b><span style="font-size:16.0pt"></span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.7pt; margin-bottom:.0001pt; text-align:center; line-height:19.5pt; text-autospace:none"> <span style="font-size:16.0pt">13:00 – 14:00</span></p> <p class="x_MsoNormal" align="center" style="text-align:center; text-autospace:none"> <span style="font-size:16.0pt"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.7pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:18.0pt">Dr Arthur Pratt will present:</span></b></p> <p class="x_MsoNormal" align="center" style="margin-top:.5pt; text-align:center; text-autospace:none"> <b><span style="font-size:13.5pt"> </span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:24.75pt; margin-bottom:0cm; margin-left:27.75pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><i><span style="font-size:16.0pt">"Molecular Profiling of Lymphocytes in Early Rheumatoid Arthritis: Pathobiology to Patient Benefit?"</span></i></b></p> <p class="x_MsoNormal" align="center" style="margin-top:.55pt; text-align:center; text-autospace:none"> <b><i><span style="font-size:11.5pt"> </span></i></b></p> <p class="x_MsoNormal" align="center" style="margin-right:5.6pt; margin-bottom:0cm; margin-left:8.7pt; margin-bottom:.0001pt; text-align:center; text-indent:-.2pt; text-autospace:none"> <span style="font-size:12.0pt">Rheumatoid arthritis is a heterogeneous disease of immune dysregulation in which lymphocytes play an orchestrating role. It remains difficult to diagnose and, despite a proliferation of available treatments, highly variable in outcome. This reflects an incomplete understanding of pathogenesis and a paucity of clinically useful stratification tools. The Newcastle Early Arthritis Clinic facilitates observational research aiming to address these challenges, whilst optimising service delivery for patients. An overview of our work will be presented, including recent efforts to understand mechanisms of genetic risk and thereby prioritise candidate causal genes for further study.</span></p> <p class="x_MsoNormal" align="center" style="text-align:center; text-autospace:none"> <span style="font-size:12.0pt"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:24.6pt; margin-bottom:0cm; margin-left:27.75pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <a name="x_Chair:_Dr_Catharien_Hilkens" id="LPlnk587453" class="OWAAutoLink" previewremoved="true"></a><b><u><span style="font-size:18.0pt">Chair</span></u></b><b><span style="font-size:18.0pt">: Dr Catharien Hilkens</span></b></p> <p class="x_MsoNormal" style="text-autospace:none"><b><span style="font-size:10.0pt"> </span></b></p> <p class="x_MsoNormal" style="margin-left:5.6pt; text-autospace:none"><span style="font-size:10.0pt"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgsqHdYXPkvU0bwpyYHZEhuSp13eCld36kA5hrth9RhEAsq5_X-vzryVGDwBbGpAwYAaP95m-cDW7Rc2uR_pYU1Mx8IxjxXSsPRSx7LFaolzaj1h3QB1nZOsTb3SXJpsN3-Rn3SdUmcmBz1/s1600/image002-747687.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgsqHdYXPkvU0bwpyYHZEhuSp13eCld36kA5hrth9RhEAsq5_X-vzryVGDwBbGpAwYAaP95m-cDW7Rc2uR_pYU1Mx8IxjxXSsPRSx7LFaolzaj1h3QB1nZOsTb3SXJpsN3-Rn3SdUmcmBz1/s320/image002-747687.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6633766169886337250" /></a></span><span style="font-size:10.0pt"></span></p> <p class="x_MsoNormal"> </p> <p class="x_MsoNormal"></p> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0tag:blogger.com,1999:blog-4805910351113340499.post-8234277646204957652018-11-19T10:04:00.001+00:002018-11-19T10:04:26.679+00:00Periprosthetic Joint Infection and Flow Cytometric Immunophenotyping of Salivary Glands in Primary Sjögren’s Syndrome<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr"> <p style="margin-top:0;margin-bottom:0"><br> </p> <div id="Signature"> <div id="divtagdefaultwrapper" style="color: rgb(0, 0, 0); font-family: Calibri, Arial, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 12pt; background-color: rgb(255, 255, 255);"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div style="font-family:Tahoma; font-size:13px"> <div> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <div style="font-family:Tahoma; font-size:13px"><font size="2"></font> <p><br> </p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div style="color: rgb(0, 0, 0);"> <div lang="EN-GB" link="#0563C1" vlink="#954F72"> <div class="x_WordSection1"> <p class="x_MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt; font-family:"Times New Roman",serif; color:red"></span></p> <p class="x_MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt; font-family:"Times New Roman",serif; color:red"> </span></p> <p class="x_MsoNormal" align="center" style="margin-left:5.0pt; text-align:center; text-autospace:none"> <span style="font-size:10.0pt; font-family:"Times New Roman",serif"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhhGJmzXCDwdPFlF7CJHUkHVo6b-xBGy-X6TLnbjo7Ej4ZWuDQga5ZNzEXLv-KOJWOBWJuOXtc_xguomYX6G0BdW695Ne1JRRbBQmJBliAm9f9iaSxmi4xn0-I0ygqzadZSV3imMBCtJpRM/s1600/image001-766684.jpg"><img src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhhGJmzXCDwdPFlF7CJHUkHVo6b-xBGy-X6TLnbjo7Ej4ZWuDQga5ZNzEXLv-KOJWOBWJuOXtc_xguomYX6G0BdW695Ne1JRRbBQmJBliAm9f9iaSxmi4xn0-I0ygqzadZSV3imMBCtJpRM/s320/image001-766684.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_6625510469921632338" /></a></span></p> <p class="x_MsoNormal" align="center" style="margin-top:.05pt; text-align:center; text-autospace:none"> <span style="font-size:12.5pt; font-family:"Times New Roman",serif"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:11.95pt; margin-bottom:0cm; margin-left:11.0pt; margin-bottom:.0001pt; text-align:center; line-height:21.35pt; text-autospace:none"> <b><span style="font-size:18.0pt">ICM Research in Progress Seminar</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:11.85pt; margin-bottom:0cm; margin-left:11.05pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:14.0pt">Monday 19</span></b><b><span style="font-size:9.0pt; top:-5.0pt">th </span></b><b><span style="font-size:14.0pt">November</span></b></p> <p class="x_MsoNormal" align="center" style="margin-top:.05pt; text-align:center; text-autospace:none"> <b><span style="font-size:17.0pt"> </span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:11.85pt; margin-bottom:0cm; margin-left:11.05pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:14.0pt">Lucy Walker</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:11.95pt; margin-bottom:0cm; margin-left:11.0pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <span style="font-size:14.0pt">(Prof. C Harwood, Prof. D Deehan)</span></p> <p class="x_MsoNormal" align="center" style="margin-right:11.95pt; margin-bottom:0cm; margin-left:10.85pt; margin-bottom:.0001pt; text-align:center; line-height:106%; text-autospace:none"> <b><span style="font-size:14.0pt; line-height:106%">The use of Alpha defensin lateral flow test in revision surgery for Periprosthetic Joint Infection</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:10.35pt; margin-bottom:0cm; margin-left:9.4pt; margin-bottom:.0001pt; text-align:center; text-indent:-.1pt; line-height:106%; text-autospace:none"> Periprosthetic joint infection (PJI) can be a devastating complication of arthroplasty surgery. There is currently no test which confirms the presence or eradication of PJI with 100% reliability. An in-theatre lateral flow test using the biomarker alpha defensin was developed for diagnosing PJI and initial results were encouraging. We conducted a prospective observational study to assess the utility of the alpha defensin lateral flow (ADLF) test in diagnosing PJI and confirming eradication after surgical debridement. We found that the ADLF test had a high specificity and PPV for confirming eradication of infection but had poor diagnostic accuracy for PJI when used on intra-operative samples.</p> <p class="x_MsoNormal" align="center" style="margin-top:.45pt; text-align:center; text-autospace:none"> <span style="font-size:15.0pt"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:11.85pt; margin-bottom:0cm; margin-left:11.05pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:14.0pt">Julia Concetti</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:11.95pt; margin-bottom:0cm; margin-left:10.9pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <span style="font-size:14.0pt">(Prof. D Mann, Dr. C Wilson, Prof. J Mann)</span></p> <p class="x_MsoNormal" align="center" style="margin-right:11.95pt; margin-bottom:0cm; margin-left:10.95pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:14.0pt">Discovering the tumour-suppressor function of the p50 subunit of NF-κB</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:11.75pt; margin-bottom:0cm; margin-left:10.95pt; margin-bottom:.0001pt; text-align:center; text-indent:-.15pt; text-autospace:none"> Global p50 knock-out mice develop more liver tumours and exhibit increased inflammation. Here, we aim to elucidate the role of p50 in hepatocytes specifically, by using a similar liver cancer model in p50 hepatocyte knock- out mice.</p> <p class="x_MsoNormal" align="center" style="margin-top:.15pt; text-align:center; text-autospace:none"> <span style="font-size:12.0pt"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:11.8pt; margin-bottom:0cm; margin-left:11.05pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:14.0pt">Dr Paul Milne</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:11.95pt; margin-bottom:0cm; margin-left:11.0pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <span style="font-size:14.0pt">(Prof. M Collin)</span></p> <p class="x_MsoNormal" align="center" style="margin-right:11.95pt; margin-bottom:0cm; margin-left:11.05pt; margin-bottom:.0001pt; text-align:center; text-autospace:none"> <b><span style="font-size:14.0pt">Flow Cytometric Immunophenotyping of Salivary Glands in Primary Sjögren's Syndrome</span></b></p> <p class="x_MsoNormal" align="center" style="margin-right:12.1pt; margin-bottom:0cm; margin-left:11.2pt; margin-bottom:.0001pt; text-align:center; text-indent:-.1pt; line-height:106%; text-autospace:none"> Primary Sjögren's Syndrome (PSS) is a common autoimmune disease of unknown aetiology. It is characterised by inflammatory infiltration of exocrine glands, development of a sicca syndrome and a 20-fold increase in the risk of developing lymphoma. Standard pathological evaluation is based on a lymphocyte 'focus score' but little is known about the composition of the lymphoid infiltrate or its relationship to disease markers such as autoantibodies and the risk of lymphoma. The aim of the study was to use flow cytometry to characterise the lymphoid infiltrate in more detail.</p> <p class="x_MsoNormal" align="center" style="margin-top:.15pt; text-align:center; text-autospace:none"> <span style="font-size:12.0pt"> </span></p> <p class="x_MsoNormal" align="center" style="margin-right:194.85pt; margin-bottom:0cm; margin-left:193.85pt; margin-bottom:.0001pt; text-align:center; text-indent:-.15pt; line-height:150%; text-autospace:none"> <b><span style="font-size:14.0pt; line-height:150%">Chair: Prateek Saxena Dental Lecture Theatre D 1pm - 2pm</span></b></p> <p class="x_MsoNormal" style="text-autospace:none"><b><span style="font-size:10.0pt"> </span></b></p> <p class="x_MsoNormal" style="margin-right:0cm; margin-bottom:.05pt; margin-left:0cm; text-autospace:none"> <b><span style="font-size:6.0pt"> </span></b></p> <p class="x_MsoNormal"></p> </div> </div> </div> </div> MRG Newcastlehttp://www.blogger.com/profile/10742667255120396003noreply@blogger.com0