Monday, 7 April 2014

Fluorescent nanosensors - Wednesday 9th April



Institute Research Seminar


Guest speaker: Dr Jon Aylott

[Associate Professor in Analytical Bioscience, School of Pharmacy, University of Nottingham]


Venue:  Lecture theatre E, ground floor, Dental School

Date and time:  Wednesday 9 April 2014 at 4.00pm


Dr Aylott will discuss:


"Fluorescent nanosensors: in situ measurements of biological systems".

Optical nanosensors are the primary focus of this research and utilise the sensitivity of fluorescence to make quantitative real-time measurements of small molecule concentrations within single cells. Nanosensors capable of measuring glucose, oxygen, calcium, zinc and pH and proteases have been demonstrated. This presentation will describe some of the methods that we are currently using to develop new sensors and detail a range of applications for nanosensors. These include the development of self-reporting scaffolds for measuring metabolic health in 3D culture systems; measuring the intestinal pH of C.elegans nematodes; and using reactive oxygen generating nanoprobes for modulating human mesenchymal stem cell behaviour.


Key words:  Fluorescence based nanosensors, real-time measurements, single cell analysis.




Biography:   Jonathan Aylott gained his degree and PhD in Chemistry from the University of East Anglia. He then undertook a Postdoctoral Fellowship in Raoul Kopelman's laboratory at the University of Michigan. In 2000, he returned to the UK to take up a Lectureship in Analytical Science at the Department of Chemistry, University of Hull. In 2004 he was appointed Lecturer in Analytical Bioscience in the School of Pharmacy at Nottingham and promoted to Associate Professor in 2011. Jon's research interests focus on the design, development and implementation of miniaturized analytical devices. Such devices can then be applied to measuring biological samples in-situ and in real-time, generating a better understanding of disease states. Jon takes a multi-disciplinary and collaborative approach to research and has obtained funding from a variety of sources to investigate the use of nanosensors in a variety of biological applications including, embryo development, stem cell biology, biofilms, photodynamic therapy and regenerative medicine.






Jon will be in Newcastle during the afternoon of 9 April – please contact Philip Manning (

if you would like an opportunity to speak with him



Chair:  Dr Philip Manning


+ Refreshments will be available in the Bites café after the meeting +








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