Immunology NE Seminar 2nd October 2014 Chronic Granulomatous Disease

 

 

  

We are very pleased to announce that next month's guest is Dr Frank van de Veerdonk, from the The Radboud University Medical Center  in Nijmegen, The Netherlands http://www.rimls.nl/themes/infectious-diseases-and-host-response, to talk on:

 

"Unravelling the ROS paradox in chronic granulomatous disease"

 

At 5pm on Thursday, October 2^nd, 2014 in room 2.21, Research Beehive, Newcastle University (refreshments will be available from 4.30 pm).

 

Franks main research interests are the mechanisms responsible for Th17 defects in patients with Hyper-IgE (HIES) and chronic mucocutaneous candidiasis (CMC). His research also focuses on host defense against aspergillus infections, and patients with chronic granolumatous disease (CGD).

The other main focus is cytokine biology with a specific interest for the interleukin-1 family of cytokines where in collaboration with Charles Dinarello, the effects of new IL‑1 family members (IL-36,IL-37 and IL-38) are being investigated for their effects in host defence against fungal infection including Th17 responses.

Franks work has been recognized by prizes including International Cytokine Society Award, Outstanding Scholar Award, the ICAAC award for young investigator in 2013 and participation in the 60^th Nobel Laureate Meeting in Lindau. 

 

If you would like to speak to Frank during his visit please contact desa.lilic@ncl.ac.uk

 

Some of Franks recent publications can be  found here:

 

de Luca, A. et al. IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. PNAS 2014

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948220

 

Gresnigt, M. S. et al. A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist. PLoS pathogens 2014

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946377

 

Gow, N. A. R., van de Veerdonk, F. L., Brown, A. J. P. & Netea, M. G. Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nature Reviews Microbiology (2012)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624162/

 

van de Veerdonk, F. L. et al. STAT1 Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis. New England Journal of Medicine (2011)

http://www.ncbi.nlm.nih.gov/pubmed/?term=21714643

 

van de Veerdonk, F. L. et al. The Macrophage Mannose Receptor Induces IL-17 in Response to Candida albicans. Cell host & microbe (2009)

http://www.ncbi.nlm.nih.gov/pubmed/19380112