Friday 29 January 2016

Rheumatoid Arthritis Centre of Excellence

...this time the RACE team met for a day of collaborative research in Birmingham.

Friday 22 January 2016

This should be interesting: the epigenetics of wound healing.






Dr Jelena Mann, Reader in Epigenetics



Dental Lecture Theatre E


Monday 25th January 2016


13.00 – 14.00pm


Dr Jelena Mann will present:


‘Epigenetic reprogramming of wound healing’



Adaptation to environmental insults is critical for ensuring fitness and survival of the species. Although long-term biological/genetic adjustment to insults exists (according to Darwinian theory), we recently discovered an alternative mechanism that provides epigenetic, heritable adaptation to an environmental insult within just 1 or 2 generations.


Liver fibrosis is a final common pathway of liver injury irrespective of aetiology. Using a model of liver injury, we show that predisposition to development of fibrosis exists and that presence of disease in previous generations alters such predisposition. Male offspring, from fathers or grandfathers that had liver injury, were protected from liver fibrosis and this adaptive response was amplified in the third generation such that the grade of disease was reduced from severe to mild. No changes in the degree of tissue injury or inflammation were observed between generations suggesting that adaptation was selectively directed at the fibrogenic/wound healing process.


The adaptation of wound healing response was also present in skin of females from the described model of transgenerational inheritance. The daughters and granddaughters of males that have had liver fibrosis had significantly diminished ability to close skin wounds, which was further evident in lower migration of skin fibroblasts in scratch-wound assays. These data show existence of transgenerational epigenetic transmission of wound healing properties and provides evidence of heritable mechanisms for the rapid adaptation of animals to environmental insults.  


Finally, we have examined possible transmission mechanisms of the acquired characteristics in sperm of adapted animals to show that histone marks, DNA methylation and small non-coding RNAs may play a role.


Chair:    Dr Muzz Haniffa



Thursday 21 January 2016

Katie Hackett & Julian Newton Talk Fatigue, Sjogrens & RA

Fatigue is one of the key symptoms of patients with musculoskeletal diseases.
Listen to Katie Hackett and Julia Newton talking about some of the problems of managing fatigue. 

Starting at about 1:10:30 into the recording.
Join Anna Foster for cracking conversation and updates to ease you through your morning.

Wednesday 20 January 2016

MRG Lab Meeting 22.1.16

The MRG Lab Meeting will be taking place on Friday 22nd January 2016 at 9.00am in the Baddiley Clark Seminar Room. 
Dennis Lendrem (Project Manager)
Natasha West - Title of Talk "Exploring the role of BCL-3 in CD4+ T cells in early rheumatoid arthritis"
David Hodgson - Title of Talk "Investigating the changes in TGF-β signalling with age using a systems biology approach"
Tariq Al Shehri - Title of Talk "Functional Analysis of STAT1 Mutation"