Tuesday 12 February 2019

III theme meeting Friday 15th February 9:15 Baddiley Clark seminar room

Our next III Theme meeting will take place on Friday 15th February at 9:15-10:45 am in the Baddiley-Clark seminar room.


Marie-Helene Ruchaud-Sparagano from John Simpson's group and Arthur Pratt will discuss their current research (30 minute each).

Monday 4 February 2019

Steve Eyre - "RA - post GWAS.

Steve Eyre from Manchester is giving tomorrow's IGM seminar at 1 PM about "RA - post GWAS.  

I have been involved in researching the genetic susceptibility to rheumatoid arthritis (RA) since I joined the Arthritis Research Centre of Excellence, based at the University of Manchester, UK in 1996. Initially focussing on linkage studies using the large collection of family samples collected at the Centre as part of the National Repository, I quickly moved onto genome wide association studies (GWAS), as part of the Wellcome Trust Case Control Consortium (WTCCC), before leading on the fine-mapping of RA loci in the Immunochip study (Nature Genetics, 2012). This study used over 27,000 samples and led to the discovery of 14 new RA susceptibility loci. In recent years my lab has focussed on understanding the mechanisms by which these DNA variants lead to an increase risk of disease. In collaboration with Peter Fraser (Babraham, Cambridge) and Chris Wallace (University of Cambridge), my group has developed methods to interrogate the regions that are associated with RA, mainly regulatory enhancer regions, to determine the interacting gene targets. Using this Capture HiC methodology we are discovering how long range interactions, often involving multiple regions associated with different autoimmune diseases, regulate gene expression. In addition I have established collaborations with Soumya Raychaudhuri (Harvard Medical School, Boston),  Caroline Ospelt (Zurich) and David Sansom (UCL), to look at the immunological, epigenetic and non-coding RNA consequences of the RA associated regions. These methods include ChIP, ATAC-Seq, RNA-seq and CRISPR genome editing.

NF-κB Transcription Factors in B-Cell Lymphomagenesis

PI Seminar Series



Ulf Klein

Professor of Immunology and Haemato-oncology Experimental Haematology,

St. James's University Hospital, University of Leeds


Dental Lecture Theatre F


Wednesday 6th February 2019


13:00 – 14:00


Prof Ulf Klein will present:


NF-κB Transcription Factors in B-Cell Lymphomagenesis

Professor Klein has been working on the molecular basis of B-cell development and lymphomagenesis throughout his career. Following his PhD at the University of Cologne, he moved to Columbia University where he was promoted to Associate Professor in 2016. In 2017, he joined the University of Leeds, where he continues his work on elucidating the oncogenic mechanisms that cause malignant transformation of B cells. Currently, a main focus of his lab lies on understanding the roles of the individual NF-κB transcription factor subunits in this process.