Three international cohorts, two clinical trials including patient reported symptoms, clinical and biological data, proteomics and transcriptomics.
See the latest paper in The Lancet Rheumatology.
PI Seminar Series
Professor Andy Mellor
Dental Lecture Theatre E
Wednesday 2nd October 2019
13:00 – 14:00
Andy Mellor will present:
"Immunotherapy for chronic diseases: Can we stop the wheels spinning?"
Chronic conditions create huge and growing health care burdens worldwide. Chronic tissue inflammation is a hallmark of many chronic conditions, including cancers, chronic infections, autoimmune cardiovascular and neuro-inflammatory diseases and allergies. Inflammation activates immune cells to incite protective responses against pathogenic organisms. If unresolved, inflammation causes progressive immune dys-function and increased risk of tissue damage and disease. Immune checkpoints discovered in mouse models of cancer offer new insights into the causes and consequences of chronic inflammation and how to manipulate inflammation to modify immune balance for clinical benefit. Our recent work on mouse models of cancer and autoimmune syndromes provides fresh perspectives on how to manipulate the immune system to prevent and treat chronic conditions
Professor Mark Walker