DRAFT Agenda for the International Forum on RA - Sept 2017
Next week we will have a talk from Jess Tarn entitled 'Latent Variable analysis of clinical phenotypes in Primary Sjogren's Syndrome'. The meeting will be in DENT.4.004 (D2.1). 11am as usual.
This should be good. Looking forward to this one...
Supervisors: Prof Wan-Fai Ng, Prof Julia Newton, Dr Tim Rapley
'Developing a non-pharmacological intervention model to improve function and participation in people with primary Sjögren's syndrome'
Primary Sjögren's syndrome (PSS) is an autoimmune disease which primarily targets secretory glands causing sicca/dryness symptoms. Patients with PSS also experience a range of other symptoms including fatigue, pain, sleep disturbances, low mood and anxiety. These symptoms impact on activities of daily living, participation and quality of life.
To design a non-pharmacological intervention strategy for people with PSS focussing on patient-relevant targets in order to improve daily function and participation.
In this project, I use a mixed methods approach. I conducted a systematic review of published interventions of non-pharmacological interventions for PSS. Then concept mapping, a participatory mixed methods approach, was used to identify factors which interfere with performance of daily activity for people with PSS. These results were discussed with a steering group and used as a basis to develop an intervention strategy. I then conducted focus groups with patients and their spouses to discuss the main factors deemed to interfere with activities, ascertain strategies patients use to manage these problems, and to determine the acceptability of potential future interventions to address these factors. Finally a model for the delivery of non-pharmacological interventions to address these factors was developed with patients.
The systematic review found there was insufficient published evidence to either support or refute non-pharmacological interventions for PSS. The concept mapping study revealed that in addition to dryness; fatigue, pain and sleep disturbances were priority targets for future interventions. The qualitative focus groups demonstrated that patients currently deploy a range of strategies to self-manage fatigue, sleep and pain. However, these strategies are not always successful and patients require individualised therapies which target their own priorities and required level of support.
This thesis provides a comprehensive understanding of factors influencing daily function and participation in PSS patients and presents a stakeholder-informed model for delivering future non-pharmacological interventions to address these factors.
12th May – 09.00
MED.L2.4 – 2nd Floor William Leech Building
This should be good...
06 April 2017
16.00 – IGM Seminar Room B107, Ground Floor West Wing, at ICfL
Professor of Translational Genomics and
Director Institute of Genetic Medicine, Newcastle
Large-scale exome and genome sequencing in genetic disease: Impact for research and diagnostics
Following the close of the lecture there will be a networking opportunity, with refreshments, in the adjacent Breakout Room.
To attend the lecture, please book a place at:
Full details of this event are available on the CHaBi web pages at: http://www.ncl.ac.uk/chabi/events/
Command line bioinformatics and high-throughput sequencing analysis. Date/Time: 4th - 6th April 2017. CHaBi seminar - Paul Burton. Date/Time: 18th May 2017 16.00
Including an interesting looking talk on prosthetic joint infection...
ICM Research Seminar
Wednesday 29th March 2017
(Dr M. White, Prof J. Shaw)
Evaluation of β-cell plasticity in Type 1 diabetes
Type 1 diabetes mellitus (T1DM) is characterized by dysfunction of insulin producing beta-cells in the pancreatic islets. Until now, cell death due to autoimmunity has been considered as the primary mechanism underlying beta-cell dysfunction in T1DM. An evolving concept in type 2 diabetes is that changes in beta-cell identity, rather than death, contribute to beta-cell dysfunction. This is characterised by loss of end-differentiated proteins and mis-expression of other, non-beta-cell hormones e.g. glucagon. This study aims at exploring whether such beta-cell plasticity events occur in T1DM.
Dr Olivier Govaere
(Prof Q. Anstee, Prof A. Daly, Prof F. Oakley)
Elucidating Pathways of Steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of disease occurring in the absence of excessive alcohol consumption that ranges from isolated hepatic triglyceride accumulation (steatosis); through hepatic triglyceride accumulation plus inflammation and hepatocyte injury (non-alcoholic steatohepatitis, NASH); and ultimately progresses to fibrosis/cirrhosis and potentially hepatocellular carcinoma. NAFLD is a common condition, strongly associated with the Metabolic Syndrome (obesity, type 2 diabetes mellitus and dyslipidaemia) and characterised by substantial inter-patient variability in severity and rate of progression. Reflecting the relatively indolent course of even advanced liver fibrosis, clinically relevant NAFLD frequently presents in the 5/6th decade and is a common cause of liver dysfunction within the ageing UK population.
Our research aims to better understand the pathogenesis of NAFLD by unravelling underlying pathways using a high-throughput RNA sequencing and DNA methylation approach. In addition, we have established an ex-vivo human model to validate our findings.
(Prof G. Burgess, Dr N. Jakubovics, Mr M. Reed)
Improved diagnosis of prosthetic joint infection using a marine nuclease
NucB an endonuclease produced from a marine bacterium Bacillus licheniformis is an effective enzyme capable of biofilm disruption by degrading extracellular DNA which is recognised as an essential component of the biofilm matrix. This research project evaluated the use of NucB to aid in the diagnosis of prosthetic joint infection, which is often challenging due to the bacteria's ability to form biofilm encapsulated communities on the prosthetic joint surface thus avoiding detection by standard microbiological culture techniques.
Chair: Zelal Kharaba
Dental Lecture Theatre F, Medical School