Tuesday, 11 December 2018

Dr Arthur Pratt - Wednesday 12th December - Dental Lecture Theatre D - 1-2pm

 

 

PI Seminar Series

 

Speaker:

Dr Arthur Pratt - Intermediate Clinical Fellow/Hon Consult

Venue:

Dental Lecture Theatre D

Date:

Wednesday 12th December 2018

Time:

13:00 – 14:00

 

Dr Arthur Pratt will present:

 

"Molecular Profiling of Lymphocytes in Early Rheumatoid Arthritis: Pathobiology to Patient Benefit?"

 

Rheumatoid arthritis is a heterogeneous disease of immune dysregulation in which lymphocytes play an orchestrating role. It remains difficult to diagnose and, despite a proliferation of available treatments, highly variable in outcome. This reflects an incomplete understanding of pathogenesis and a paucity of clinically useful stratification tools. The Newcastle Early Arthritis Clinic facilitates observational research aiming to address these challenges, whilst optimising service delivery for patients. An overview of our work will be presented, including recent efforts to understand mechanisms of genetic risk and thereby prioritise candidate causal genes for further study.

 

Chair: Dr Catharien Hilkens

 

 

Monday, 19 November 2018

Periprosthetic Joint Infection and Flow Cytometric Immunophenotyping of Salivary Glands in Primary Sjögren’s Syndrome



 

 

ICM Research in Progress Seminar

Monday 19th November

 

Lucy Walker

(Prof. C Harwood, Prof. D Deehan)

The use of Alpha defensin lateral flow test in revision surgery for Periprosthetic Joint Infection

Periprosthetic joint infection (PJI) can be a devastating complication of arthroplasty surgery. There is currently no test which confirms the presence or eradication of PJI with 100% reliability. An in-theatre lateral flow test using the biomarker alpha defensin was developed for diagnosing PJI and initial results were encouraging. We conducted a prospective observational study to assess the utility of the alpha defensin lateral flow (ADLF) test in diagnosing PJI and confirming eradication after surgical debridement. We found that the ADLF test had a high specificity and PPV for confirming eradication of infection but had poor diagnostic accuracy for PJI when used on intra-operative samples.

 

Julia Concetti

(Prof. D Mann, Dr. C Wilson, Prof. J Mann)

Discovering the tumour-suppressor function of the p50 subunit of NF-κB

Global p50 knock-out mice develop more liver tumours and exhibit increased inflammation. Here, we aim to elucidate the role of p50 in hepatocytes specifically, by using a similar liver cancer model in p50 hepatocyte knock- out mice.

 

Dr Paul Milne

(Prof. M Collin)

Flow Cytometric Immunophenotyping of Salivary Glands in Primary Sjögren's Syndrome

Primary Sjögren's Syndrome (PSS) is a common autoimmune disease of unknown aetiology.  It is characterised by inflammatory infiltration of exocrine glands, development of a sicca syndrome and a 20-fold increase in the risk of developing lymphoma.  Standard pathological evaluation is based on a lymphocyte 'focus score' but little is known about the composition of the lymphoid infiltrate or its relationship to disease markers such as autoantibodies and the risk of lymphoma. The aim of the study was to use flow cytometry to characterise the lymphoid infiltrate in more detail.

 

Chair: Prateek Saxena Dental Lecture Theatre D 1pm - 2pm

 

 

Wednesday, 7 November 2018

Prof Katja Simon - Wednesday 7th November - Ridley 2 - 1.65 - 1 to 2pm

 

 

PI Seminar Series

 

Speaker:

Prof Katja Simon – The Kennedy Institute, University of Oxford

Venue:

Ridley 2 – 1.65

Date:

Wednesday 7th November 2018

Time:

13:00 – 14:00

 

Prof Katja Simon will present:

 

"Autophagy in the immune system"

 

Autophagy is a conserved major cellular degradation process that delivers unwanted bulk cytoplasmic material to the lysosome. It takes place in every cell at all times at basic level, however, it can be induced to recycle material when nutrients are scarce. In addition unwanted organelles and macromolecules are turned over via autophagy once they have been labeled for degradation.

Our in vivo work has demonstrated that under physiological conditions autophagy determines cell fate: it prevents cell death and cellular ageing, and maintains the life span of long-lived cells in particular.

Our recent results also show that autophagy is key to normal differentiation of hematopoietic cells.

Cellular differentiation requires remodeling of the cytoplasm and change of metabolism. Autophagy's contribution to this process is the maintenance of mitochondrial quality and generation of ATP via fatty acid oxidation. We have also recently uncovered a novel pathway signaling for autophagy that relies on translation and is key to rejuvenation of the aging immune system. I will summarise our data on autophagy's impact on the immune system, with a particular emphasis on differentiation, maintenance and aging in mouse and human.

 

Chair: Prof Muzlifah Haniffa

 

 


 

Friday, 19 October 2018

Monday 22nd October

Becky Zhu
(Prof. M Birch-Machin, Dr. K Anderson, Prof. M Catt, Prof. M Trenell)
The impact of sleep on metabolic health.
Sleep deprivation is very common in modern society and has been identified as a major modifiable risk factor for many metabolic diseases. Using data from the UK Biobank, a cross-sectional analysis was carried out to investigate the association between objective sleep duration and metabolic health.
 
Chair: Duaa Altuwairki Dental Lecture Theatre D 1pm - 2pm




Thursday, 2 August 2018

RA-MAP joins IMID-Bio

As many will know the RA-MAP consortium has joined forces with other consortia to better understand immune-mediated inflammatory diseases.

The IMID-BIO project brings together a number of consortia from across the UK.

This is the future of open collaborative research in science.

We are excited about this!

You can read the latest IMID-BIO newsletter here:

And follow them on twitter @imidbio