Wednesday, 7 November 2018

Prof Katja Simon - Wednesday 7th November - Ridley 2 - 1.65 - 1 to 2pm

 

 

PI Seminar Series

 

Speaker:

Prof Katja Simon – The Kennedy Institute, University of Oxford

Venue:

Ridley 2 – 1.65

Date:

Wednesday 7th November 2018

Time:

13:00 – 14:00

 

Prof Katja Simon will present:

 

"Autophagy in the immune system"

 

Autophagy is a conserved major cellular degradation process that delivers unwanted bulk cytoplasmic material to the lysosome. It takes place in every cell at all times at basic level, however, it can be induced to recycle material when nutrients are scarce. In addition unwanted organelles and macromolecules are turned over via autophagy once they have been labeled for degradation.

Our in vivo work has demonstrated that under physiological conditions autophagy determines cell fate: it prevents cell death and cellular ageing, and maintains the life span of long-lived cells in particular.

Our recent results also show that autophagy is key to normal differentiation of hematopoietic cells.

Cellular differentiation requires remodeling of the cytoplasm and change of metabolism. Autophagy's contribution to this process is the maintenance of mitochondrial quality and generation of ATP via fatty acid oxidation. We have also recently uncovered a novel pathway signaling for autophagy that relies on translation and is key to rejuvenation of the aging immune system. I will summarise our data on autophagy's impact on the immune system, with a particular emphasis on differentiation, maintenance and aging in mouse and human.

 

Chair: Prof Muzlifah Haniffa

 

 


 

Friday, 19 October 2018

Monday 22nd October

Becky Zhu
(Prof. M Birch-Machin, Dr. K Anderson, Prof. M Catt, Prof. M Trenell)
The impact of sleep on metabolic health.
Sleep deprivation is very common in modern society and has been identified as a major modifiable risk factor for many metabolic diseases. Using data from the UK Biobank, a cross-sectional analysis was carried out to investigate the association between objective sleep duration and metabolic health.
 
Chair: Duaa Altuwairki Dental Lecture Theatre D 1pm - 2pm




Thursday, 2 August 2018

RA-MAP joins IMID-Bio

As many will know the RA-MAP consortium has joined forces with other consortia to better understand immune-mediated inflammatory diseases.

The IMID-BIO project brings together a number of consortia from across the UK.

This is the future of open collaborative research in science.

We are excited about this!

You can read the latest IMID-BIO newsletter here:

And follow them on twitter @imidbio

Thursday, 8 February 2018

Ken Baker - Thursday 1st March - 12.15pm - MED.L2.6

This should be interesting 😊

 

 

 

 

VIVA Seminar

 

Speaker: Ken Baker

Supervisors: Prof John Isaacs, Dr Arthur Pratt, Dr Ben Thompson

 

Predictors of Drug-Free Remission in Rheumatoid Arthritis

 

Background  Rheumatoid arthritis (RA) is a common autoimmune disease characterised by joint inflammation and systemic manifestations. Remission is achievable with disease- modifying anti-rheumatic drugs (DMARDs) prescribed in modern treat-to-target strategies, albeit with potential side effects, and inconvenient and expensive safety monitoring. Half of patients can maintain remission following DMARD cessation, though this cannot be reliably predicted. Clinicians and patients thus face a dilemma – when is it appropriate to stop DMARDs in RA remission?

Method Patients with established RA satisfying clinical and ultrasound remission criteria discontinued all DMARDs and were monitored for six months. The primary outcome was time-to-flare, defined as DAS28-CRP (disease activity score in 28 joints with C-reactive protein) ≥ 2.4. Baseline clinical and ultrasound measures, circulating cytokines, and peripheral CD4+ T cell gene expression were assessed for their ability to predict time-to- flare and flare/remission status by Cox regression and receiver-operating characteristic (ROC) analysis.

Results 23/44 (52%) eligible patients experienced an arthritis flare at a median (IQR) of 48 (31.5 – 86.5) days following DMARD cessation. A composite score incorporating five baseline variables (three genes, one cytokine and one clinical) differentiated future flare and drug- free remission with an area under the ROC curve of 0.96 (95% CI 0.92-1.00), sensitivity of

0.91 (0.78 – 1.00) and specificity of 0.95 (0.84 – 1.00). Longitudinal analysis identified increased concentrations of circulating pro-inflammatory cytokines, and upregulation of a

proliferative gene set by CD4+ T cells at the onset of flare.

Conclusions This study provides proof-of-concept evidence for the existence of biomarkers of drug-free remission in RA, and offers insights to the pathophysiology of arthritis flare. If validated, these biomarkers may help guide DMARD withdrawal, with consequent minimisation of medication side effects and healthcare costs.

 

Thursday 1st March, 12.15pm

Room L2.6, 2nd Floor William Leech Building

Monday, 29 January 2018

ICM Research Seminar - Wednesday 31st January - Dental Lecture Theatre F - 1pm

This could be interesting... 

 

 

 

 

ICM Research Seminar

Wednesday 31st January

 

Khalil Elgendy

(Prof John Mathers, Dr Fiona Malcomson)

DNA methylation as a biomarker of colorectal cancer risk: evaluation of surrogate tissues

This research project aims to investigate the relationship between DNA methylation in different tissues (longitudinal and cross-sectional approaches) in context of colorectal cancer (CRC) risk which may have an impact on development of more informative biomarkers for assessment of CRC risk and potential use as surrogate outcomes in studies of CRC prevention.

 

Dr Peter Vegh

(Prof Muzlifah Haniffa)

Application of single-cell RNA analysis in immunology

Modern sequencing technologies allow us to individually measure the transcriptomes of thousands of cells from the same sample. As the transcriptome is a good reflection of cell type and function, we employ this approach to examine the composition of human tissues, with a particular focus on the immune system. This presentation describes the workflow and illustrates its use in our study of healthy human skin. Our aim is to map and catalogue cell heterogeneity, an important step to understanding the immune system.

 

Chair: Carl Dale

Dental Lecture Theatre F, Medical School 1pm - 2pm