Wednesday, 12 October 2016

ADVANCE NOTICE: The Fourth International Workshop on Therapeutic Tolerancing


Therapeutic Tolerance Workshop 27-30th June 2017

Confirmed Speakers

R Germaine, (Bethesda, USA)

Keynote address: Imaging the immune system


G Hollander (Oxford, UK)

The thymus – an update


E Shevach (Bethesda, USA)

Regulatory T cells


F Powrie (Oxford, UK)

Manipulating the microbiome for tolerance induction


D Sansom (London, UK)

What does CTLA4 really do?


S Khleif (Augusta, USA)

Title TBC


T Johnson (Augusta, USA)

Trials and tribulations in breaking tumour tolerance


PP Tak (Stevenage, UK)

Immunomodulation by vagal nerve stimulation


H Jonuleit (Mainz, Germany)

Tolerogenic targets in regulatory T cells


I Anegon (Nantes, France)

Novel mechanisms in tolerance induction


J Isaacs (Newcastle, UK)

Update on the RA-MAP consortium


M Hernandez-Fuentes (London, UK)

Biomarkers in transplantation tolerance


G Kassiotis (London, UK)

Endogenous retroviruses and the breakdown of immune tolerance


G Lombardi (London, UK)

Tregs in kidney transplantation


R Thomas (Brisbane Australia)

A platform for peptide therapeutics


G Schett (Erlangen, Germany)

Autoantibodies as tolerance biomarkers


M Trucco (Pittsburgh, USA)

Tolerogenic therapies for type I diabetes


L Chatenoud (Paris, France)

Anti-CD3 – an update


A Coles (Cambridge, UK)

Alemtuzumab in Multiple Sclerosis


M Ehrenstein (London, UK)

Anti-TNF as a tolerogenic therapy


A Mellor (Newcastle, UK)

IDO and tolerance – where are we now?


D Howie (Oxford, UK)

How FoxP3 regulates immune metabolism


L Graca (Lisbon, Portugal)

Tolerance to Factor VIII


H Waldmann (Oxford, UK)

Novel antibodies with improved properties?


J van Laar (Utrecht, The Netherlands)

Hematologic transplantation as a therapy for autoimmunity


A Radbruch (Berlin, Germany)

Restoring B cell tolerance


F van Wijk (Utrecht, The Netherlands)

Resetting T cell regulation in JIA


M Bernardo (Milan, Italy)

Mesenchymal for tolerance induction


D Wraith (Birmingham, UK)

Peptide therapy in MS and other conditions


L Klareskog (Stockholm, Sweden)

Evolution of an autoimmune disease


P Trzonkowski (Gdansk, Poland)

Treg therapies in type I diabetes


C Mauri (London, UK)

Regulator B Cells


K Kishimoto (Massachusetts , USA)

Tolerogenic nanoparticles


R Wilkinson (Cambridge, UK)

Title TBC


For further information please contact lisa.tait  @


Friday, 16 September 2016

ICM Special Seminar - Monday 19th Sept - Immune Mapping in Ankylosing Spondylitis - Translational Medicine



Speaker:         Dr Tony Kenna, Queensland University of Technology

Venue:   Baddiley Clark Seminar Room

Date:       Monday 19th September, 2016

Time:       16.30 -17.30



Dr Tony Kenna will present:


“Immune mapping” in ankylosing spondylitis: challenges of translating GWAS to functional immunology




My research career has focussed on human immunology and functional characterisation of novel genes in autoinflammatory disease. For the past 6 years I have been particularly focused on pathways of inflammation in ankylosing spondylitis (AS) and related immune-mediated diseases. My research productivity in this area is impressive, of my 18 publications since 2011 14 have been in the area of AS research. I work closely with clinicians and have established a curated biobank of cells, serum, RNA, DNA and gut biopsies from over 400 AS patients and 200 healthy controls with which to interrogate altered immune function in patients relative to healthy individuals. I have also used this biobank to investigate fundamental biology of the immune response. I lead a highly skilled and motivated group of research professionals and students.


My work enriches our fundamental knowledge of human immunology and will likely lead to identification of novel therapeutic candidates.



Chair: Professor John Isaacs





Monday, 5 September 2016




Simulated interventions to ameliorate age-related bone loss indicate the importance of timing. Proctor, CJ; Gartland A. Frontiers in Endocrinology, Bone Research (2016) doi: 10.3389/fendo.2016.00061

Decoding the regulatory landscape of ageing tissue engineered musculoskeletal constructs using genome-wide DNA methylation and RNASeq.  Peffers MJ, PhD; Whysall K; Collins J; Fang Y;  Rushton M; Loughlin J; Proctor C; Clegg PD. PLoS ONE 11 (8): e0160517. doi:10.1371/journal.pone.0160517

Paper accepted for publication:

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. Phillip Lord, Rachel Spiering, Juan C. Aguillón, Amy E. Anderson, Silke Appel, Daniel Benitez-Ribas, Anja ten Brinke, Femke Broere, Nathalie Cools, Maria Cristina Cuturi, Julie Diboll, Edward K. Geissler, Nick Giannoukakis, Silvia Gregori, S. Marieke van Ham,Staci Lattimer, Lindsay Marshall, Rachel A. Harry, James A. Hutchinson, John D. Isaacs, Irma Joosten, Cees van Kooten, Ascensión López Díaz de Cerio, Tatjana Nikolic, Haluk Barbaros Oral, Ljiljana Sofronic-Milosavljevic, Thomas Ritter, Paloma Riquelme, Angus W. Thomson, Massimo Trucco, Marta Vives-Pi, Eva Martinez-Caceres, Catharien M.U. Hilkens.  (2016). PeerJ 4:e2300; DOI 10.7717/peerj.2300

Infection-Related Death among Persons with Refractory Juvenile Idiopathic Arthritis.  Mario Abinun, Jonathan P. Lane, Mark Wood, Mark Friswell, Terence J. Flood, Helen E. Foster.  Emerging Infectious Diseases.  Vol 22, No 10, October 2016.
Volume 22, Number 9—September 2016 - Emerging Infectious Disease journal - CDC


Sarah Cope (Master’s in Medical Education - PI Helen Foster) Start Date 16.08.16

Joseph Dudman (PhD Student in Mechanical Engineering & Systems - PI Kenny Dalgarno) Start date to be confirmed

Leonie Schittenhelm (PhD Student - PI Catharien Hilkens) Start Date 26.09.16 


Chun Ming Chan (Research Associate - Desa Lilic/Drew Rowan) 31.08.16

Colin Shepherd (Research Associate - John Loughlin/Louise Reynard) 31.08.16


Dr Christopher Duncan has been successful in obtaining a 1 year Research Fellowship from the British Infection Association.

Monday, 22 August 2016


We would like to welcome the following people below:

Ian Herron who is a Student from Sunderland University will be with us from 4.6.16 for 8 weeks and his Supervisor is Sophie Hambleton. 

Andreia Mariha de Sousa Almeida who is a Visiting Researcher will be with us from 1.7.16 for 1 month and her Supervisor is Kenny Dalgarno.

Maria Addlororata Bonifacio who is a PhD Student from University of Bari in Italy will be with us from 17.6.16 for 4 months 

Monday, 25 July 2016

MHRA presentation on Medical Apps

The regulation of medical apps - a presentation from the MHRA.

Translational research increasingly leads to the production of apps, aimed either at patients or clinicians.

What are the regulatory considerations?

Speaker: Valerie Field, Interim Group Manager, Devices, MHRA
Venue: David Shaw Lecture Theatre, Medical School
Time: 12.30pm
Date: Tuesday 26 July