Friday, 16 September 2016

ICM Special Seminar - Monday 19th Sept - Immune Mapping in Ankylosing Spondylitis - Translational Medicine



Speaker:         Dr Tony Kenna, Queensland University of Technology

Venue:   Baddiley Clark Seminar Room

Date:       Monday 19th September, 2016

Time:       16.30 -17.30



Dr Tony Kenna will present:


“Immune mapping” in ankylosing spondylitis: challenges of translating GWAS to functional immunology




My research career has focussed on human immunology and functional characterisation of novel genes in autoinflammatory disease. For the past 6 years I have been particularly focused on pathways of inflammation in ankylosing spondylitis (AS) and related immune-mediated diseases. My research productivity in this area is impressive, of my 18 publications since 2011 14 have been in the area of AS research. I work closely with clinicians and have established a curated biobank of cells, serum, RNA, DNA and gut biopsies from over 400 AS patients and 200 healthy controls with which to interrogate altered immune function in patients relative to healthy individuals. I have also used this biobank to investigate fundamental biology of the immune response. I lead a highly skilled and motivated group of research professionals and students.


My work enriches our fundamental knowledge of human immunology and will likely lead to identification of novel therapeutic candidates.



Chair: Professor John Isaacs





Monday, 5 September 2016




Simulated interventions to ameliorate age-related bone loss indicate the importance of timing. Proctor, CJ; Gartland A. Frontiers in Endocrinology, Bone Research (2016) doi: 10.3389/fendo.2016.00061

Decoding the regulatory landscape of ageing tissue engineered musculoskeletal constructs using genome-wide DNA methylation and RNASeq.  Peffers MJ, PhD; Whysall K; Collins J; Fang Y;  Rushton M; Loughlin J; Proctor C; Clegg PD. PLoS ONE 11 (8): e0160517. doi:10.1371/journal.pone.0160517

Paper accepted for publication:

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. Phillip Lord, Rachel Spiering, Juan C. Aguillón, Amy E. Anderson, Silke Appel, Daniel Benitez-Ribas, Anja ten Brinke, Femke Broere, Nathalie Cools, Maria Cristina Cuturi, Julie Diboll, Edward K. Geissler, Nick Giannoukakis, Silvia Gregori, S. Marieke van Ham,Staci Lattimer, Lindsay Marshall, Rachel A. Harry, James A. Hutchinson, John D. Isaacs, Irma Joosten, Cees van Kooten, Ascensión López Díaz de Cerio, Tatjana Nikolic, Haluk Barbaros Oral, Ljiljana Sofronic-Milosavljevic, Thomas Ritter, Paloma Riquelme, Angus W. Thomson, Massimo Trucco, Marta Vives-Pi, Eva Martinez-Caceres, Catharien M.U. Hilkens.  (2016). PeerJ 4:e2300; DOI 10.7717/peerj.2300

Infection-Related Death among Persons with Refractory Juvenile Idiopathic Arthritis.  Mario Abinun, Jonathan P. Lane, Mark Wood, Mark Friswell, Terence J. Flood, Helen E. Foster.  Emerging Infectious Diseases.  Vol 22, No 10, October 2016.
Volume 22, Number 9—September 2016 - Emerging Infectious Disease journal - CDC


Sarah Cope (Master’s in Medical Education - PI Helen Foster) Start Date 16.08.16

Joseph Dudman (PhD Student in Mechanical Engineering & Systems - PI Kenny Dalgarno) Start date to be confirmed

Leonie Schittenhelm (PhD Student - PI Catharien Hilkens) Start Date 26.09.16 


Chun Ming Chan (Research Associate - Desa Lilic/Drew Rowan) 31.08.16

Colin Shepherd (Research Associate - John Loughlin/Louise Reynard) 31.08.16


Dr Christopher Duncan has been successful in obtaining a 1 year Research Fellowship from the British Infection Association.

Monday, 22 August 2016


We would like to welcome the following people below:

Ian Herron who is a Student from Sunderland University will be with us from 4.6.16 for 8 weeks and his Supervisor is Sophie Hambleton. 

Andreia Mariha de Sousa Almeida who is a Visiting Researcher will be with us from 1.7.16 for 1 month and her Supervisor is Kenny Dalgarno.

Maria Addlororata Bonifacio who is a PhD Student from University of Bari in Italy will be with us from 17.6.16 for 4 months 

Monday, 25 July 2016

MHRA presentation on Medical Apps

The regulation of medical apps - a presentation from the MHRA.

Translational research increasingly leads to the production of apps, aimed either at patients or clinicians.

What are the regulatory considerations?

Speaker: Valerie Field, Interim Group Manager, Devices, MHRA
Venue: David Shaw Lecture Theatre, Medical School
Time: 12.30pm
Date: Tuesday 26 July

Wednesday, 20 July 2016

Latest Papers

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype: an international survey of 274 patients from 167 kindreds.  Julie Toubiana, MD1,2,3,4, Satoshi Okada, PhD5,6, Julia Hiller, MD7,8,*, Matias Oleastro, MD9,*, Macarena Lagos Gomez, MD10,*, Juan Carlos Aldave Becerra, MD11,*, Marie Ouaché-Chardin, MD12,*, Fanny Fouyssac, MD13,*, Katta Mohan Girisha, MD14,¥, Amos Etzioni, MD15,¥, Joris Van Montfrans, MD16,¥, Yildiz Camcioglu, MD17,¥, Leigh Ann Kerns, MD18,¥,, Bernd Belohradsky, MD19, ¥, Stéphane Blanche, MD2,4,¥, Aziz Bousfiha, MD20,¥, Carlos Rodriguez-Gallego, MD21,¥, Isabelle Meyts22,¥, Kai Kisand, MD23,¥, Janine Reichenbach, MD24,¥, Ellen D Renner, MD19,#, Sergio Rosenzweig, MD25,#, Bodo Grimbacher, MD26,# , Frank L van de Veerdonk, MD27,#, Claudia Traidl-Hoffmann, M7,8,#, Capucine Picard, MD2,3,4,28,#, Laszlo Marodi, MD29,#, Tomohiro Morio, MD30,#, Masao Kobayashi, MD6,#, Desa Lilic, MD31,#,  Joshua D Milner, MD32,#, Steven Holland, MD25,#, Jean-Laurent Casanova, MD2,3,5,33,@ and Anne Puel, PhD2,3,5,34,@ , on behalf of the International STAT1-GOF study group† European Journal of Immunology

Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5  balance.  Christopher Tibbitt, Jane Falconer, Jeroen Stoop, Willem van Eden, John H.Robinson and Catharien M.U. Hilkens European Journal of Immunology

Drug breakthrough offers hope to arthritis sufferers: qualitative analysis of medical research in UK newspapers.  Hanson, H., O'Brien, N., Whybrow, P., Isaacs, J.D. and Rapley, T. Health Expectations. (2016), doi: 10.1111/hex.12460

Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study.  Flora McErlane, Helen E. Foster, Roberto Carrasco, Eileen M. Baildam, S.E. Alice Chieng, Joyce E. Davidson, Yiannis Ioannou, Lucy R. Wedderburn, Wendy Thomson and Kimme L. Hyrich.  Rheumatology (2106) 55:1223-1234.