Wednesday, 15 November 2017

ICM Research Seminar - Wednesday 15th November - Dental Lecture Theatre F - 1pm to 2pm

Some interesting talks today.  Go Edith!

 

 

 

ICM Research Seminar

Wednesday 15th November

Rebecca Hanna

(Prof. M. Birch-Machin, Dr S. Amarnath)

Optimised detection of mitochondrial DNA strand breaks

Intrinsic and extrinsic factors that induce cellular oxidative stress will damage tissue integrity and promote ageing. At a sub- cellular level, this results in accumulative strand breaks to the mitochondrial DNA (mtDNA) genome. Limited repair mechanisms and close proximity of the genome to the site of superoxide generation, make mtDNA a prominent biomarker of oxidative damage. Using human DNA extracted by conventional methods, we describe a methodology that sensitively detects mtDNA strand breaks relative to a suite of short mitochondrial and nuclear DNA housekeeping amplicons which control for any variation in copy number. Some applications of this methodology will be discussed.

 

James Fletcher

(Prof. M. Haniffa, Prof. N. Reynolds)

Defining the landscape of human tissue mononuclear phagocytes using single cell RNA sequencing and mass cytometry

The mononuclear phagocyte system is a highly heterogeneous compartment of the immune system comprising many subsets of monocytes, macrophages and dendritic cells. As single cell analysis techniques increase in measurable parameters, this heterogeneity can be analysed in greater detail. Using human skin as a model organ for tissue immune cells, this project aims to utilise single cell RNA sequencing to dissect the human tissue mononuclear phagocyte compartment, and validate these findings using flow and mass cytometry.

 

Dr Edith Serrano Blesa

(Prof. J. Isaacs)

Use of Design of Experiments to optimize a SWATH-MS acquisition method for the discovery of protein biomarkers in serum

SWATH-MS is a recently described mass spectrometry technique that allows high coverage protein identification and accurate quantification. The parameters that impact detection by SWATH-MS are specially complex and so, optimization is sample and machine dependant. Design of experiments (DoE) uses statistical methodology for identifying the significant parameters and then optimising a response by fine-tuning them, thus improving the results in the analysis of complex protein samples.

 

Chair: Dr David Swan

Dental Lecture Theatre F,

Medical School 1pm - 2pm


 

Wednesday, 4 October 2017

Fw: Centre for Health & Bioinformatics - Visiting Lecturer - 05 October 2017 at 16.00

 

 

 

Centre for Health & Bioinformatics

 

Dr Boguslaw Obara

 

Associate Professor

School of Engineering and Computing Sciences

Durham University,

 

05 October 2017

 

16.00 – Dental Lecture Theatre F, Faculty of Medical Sciences

 

BioImage Informatics: Where BioImaging Meets Computer Science

Recent advances in imaging technologies are now enabling us to acquire image data, where the sheer size and complexity of the data exceeds the capacity of human analysis, creating a fundamental barrier that hinders the potential impact of imaging-enabled biology.  New revolutions in the field can be made possible only by developing the tools, technologies and workflows to extract and exploit information from imaging data so as to achieve new fundamental biological insights and understanding, as well as developing possible strategies in biotechnological applications.

We are proposing to integrate bioimaging data and bioimage informatics to investigate the multi-scale topology and dynamics of complex biological systems.  We have developed a wide range of high-throughput image processing approaches specifically designed to enhance, extract, analyse and model a wide range of biological structures, including molecules, plant cells and their organelles, pollen tubes, fungal and cytoskeletal networks, leaves, and many more, from multidimensional images obtained by a wide spectrum of bioimaging modalities

 

 

 

Followed by:

Post lecture networking at 17.00light refreshments available

 

 

To attend the lecture, please book a place at:

https://forms.ncl.ac.uk/view.php?id=361254


 

 

 

Monday, 2 October 2017

ICM PI Seminar: TODAY


Please note the earlier than usual start time of 12.00noon.

 

 

 

PI Seminar Series

 

Speaker:         Professor Brigitta Stockinger, Francis Crick Institute

Venue:            Baddiley Clark Seminar Room

Date:         Monday 2nd October 2017

Time:                 12.00 – 13.00

 

 

Professor Gitta Stockinger will present:

 

"Environmental influences on intestinal homeostasis and inflammation"

 

 

 

 

 

 

Chair: Professor Muzz Haniffa

 

 

TEDx is coming to Newcastle University!




After only three days of recruitment at the Newcastle Societies Fair, we have had 460 people express their interest in TEDxNewcastleUniversity society. 

So, as a result, we are having two taster sessions:


Wednesday 7pm & Thursday 6pm 

@Kings Gate level 1 (Career Service area)


FREE for all!


Come along to check it our if you are still deciding joining us!

You will also have a chance to get to know what the society is all about and see all the amazing opportunities available to you through TEDx. We will introduce ourselves and our aims for this year as well as tell you a bit more about how you can get involved in TEDx conference in March!



Please click the button below to join our Facebook group for updates on everything that is happening at TED world straight to your News Feed.
Also visit our Taster Session event page for more information and click on "GOING" so we know the appoximate number of people who are going to turn up.

Click here for TEDxNewcastleUniversity Taster Session event



How do you join the TEDx SOCIETY?
It is just £5 to join the TEDx society and become a member.

Visit our NUSU page https://www.nusu.co.uk/getinvolved/societies/society/25793/ put membership to your basket and continue with the payment :)

The quicker you pay to join the society, the more money we get to hold awesome sessions!

This includes:
1. FREE entry to all of our workshops and sessions (involving live speakers!)

2. FREE beverages and snacks provided in our sessions
3. FREE or discounted entry to all of our socials

4. DISCOUNTED entry along with other benefits in the TEDxNewcastleUniversity conference in March 2018!


If you have any questions, feel free to contact us. We hope to see you at the taster!


The TEDx Newcastle University Society committee 😊

Tuesday, 26 September 2017

On This Day:Twenty Five Years Ago

Monoclonal antibodies have transformed the treatment of rheumatoid arthritis in the last 25 years. 

And today?  Today marks the 25th anniversary of the first phase 1 trial of immunotherapy for rheumatoid arthritis [Isaacs JD, Hale G, Cobbold SP, Waldmann H, Watts RA, Hazleman BL, Keogan T 1992 Humanised monoclonal antibody therapy for rheumatoid arthritis Lancet Volume 340, No. 8822, p748–752, 26 September 1992]. 

While monoclonal antibodies treatments have transformed the treatment of RA the search for a cure continues.  The story is not yet over and this week saw the launch of the RTCure project in Stockholm.  You can follow this project on the Twitter handle @RTCure_eu https://twitter.com/RTCure_eu