Monday, 22 August 2016


We would like to welcome the following people below:

Ian Herron who is a Student from Sunderland University will be with us from 4.6.16 for 8 weeks and his Supervisor is Sophie Hambleton. 

Andreia Mariha de Sousa Almeida who is a Visiting Researcher will be with us from 1.7.16 for 1 month and her Supervisor is Kenny Dalgarno.

Maria Addlororata Bonifacio who is a PhD Student from University of Bari in Italy will be with us from 17.6.16 for 4 months 

Monday, 25 July 2016

MHRA presentation on Medical Apps

The regulation of medical apps - a presentation from the MHRA.

Translational research increasingly leads to the production of apps, aimed either at patients or clinicians.

What are the regulatory considerations?

Speaker: Valerie Field, Interim Group Manager, Devices, MHRA
Venue: David Shaw Lecture Theatre, Medical School
Time: 12.30pm
Date: Tuesday 26 July

Wednesday, 20 July 2016

Latest Papers

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype: an international survey of 274 patients from 167 kindreds.  Julie Toubiana, MD1,2,3,4, Satoshi Okada, PhD5,6, Julia Hiller, MD7,8,*, Matias Oleastro, MD9,*, Macarena Lagos Gomez, MD10,*, Juan Carlos Aldave Becerra, MD11,*, Marie Ouaché-Chardin, MD12,*, Fanny Fouyssac, MD13,*, Katta Mohan Girisha, MD14,¥, Amos Etzioni, MD15,¥, Joris Van Montfrans, MD16,¥, Yildiz Camcioglu, MD17,¥, Leigh Ann Kerns, MD18,¥,, Bernd Belohradsky, MD19, ¥, Stéphane Blanche, MD2,4,¥, Aziz Bousfiha, MD20,¥, Carlos Rodriguez-Gallego, MD21,¥, Isabelle Meyts22,¥, Kai Kisand, MD23,¥, Janine Reichenbach, MD24,¥, Ellen D Renner, MD19,#, Sergio Rosenzweig, MD25,#, Bodo Grimbacher, MD26,# , Frank L van de Veerdonk, MD27,#, Claudia Traidl-Hoffmann, M7,8,#, Capucine Picard, MD2,3,4,28,#, Laszlo Marodi, MD29,#, Tomohiro Morio, MD30,#, Masao Kobayashi, MD6,#, Desa Lilic, MD31,#,  Joshua D Milner, MD32,#, Steven Holland, MD25,#, Jean-Laurent Casanova, MD2,3,5,33,@ and Anne Puel, PhD2,3,5,34,@ , on behalf of the International STAT1-GOF study group† European Journal of Immunology

Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5  balance.  Christopher Tibbitt, Jane Falconer, Jeroen Stoop, Willem van Eden, John H.Robinson and Catharien M.U. Hilkens European Journal of Immunology

Drug breakthrough offers hope to arthritis sufferers: qualitative analysis of medical research in UK newspapers.  Hanson, H., O'Brien, N., Whybrow, P., Isaacs, J.D. and Rapley, T. Health Expectations. (2016), doi: 10.1111/hex.12460

Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study.  Flora McErlane, Helen E. Foster, Roberto Carrasco, Eileen M. Baildam, S.E. Alice Chieng, Joyce E. Davidson, Yiannis Ioannou, Lucy R. Wedderburn, Wendy Thomson and Kimme L. Hyrich.  Rheumatology (2106) 55:1223-1234.

Tuesday, 19 July 2016

MRG Lab Meeting - 22.7.16

The MRG Lab Meeting will be taking place on Friday 22nd July 2016 at 9.00am in the Baddiley Clark Seminar Room.
Sarah Rice (Research Associate - Supervisors - John Loughlin and Louise Reynard)
Joe Willet (Research Associate - Supervisor - Sophie Hambleton) Title of Talk "Investigating the molecular mechanisms of a novel form of Omenn’s syndrome"
Dimitra Tsompani (PhD Student - Supervisors - David Young and Drew Rowan) Title of Talk "The Role of Histone Deacetylase 3 (HDAC3) in Chondrogeneisis and in Osteoarthritis"
Matt Wood (PhD Student - Supervisor – Cat Hilkens) "Do synovial dendritic cells contribute to the pathogenesis of rheumatoid arthritis?"

Friday, 15 July 2016


And in other news...

Dipika Asher has just completed her second year at Newcastle. Started MRG on         13th June 2016 and finished on 24th June 2016.  Dipika was shadowing Sarah Rice and under the supervision of John Loughlin.

Eleanor Wheeler has just completed her first year at Sheffield.  Started MRG on 20th June 2016 and will be finishing on 5th August 2016.  Eleanor is working with Maria Tselepi and under the supervision of John Loughlin.