Monday, 16 September 2019

Lancet Seminar on Sarcopenia

Check out the Lancet seminar on sarcopenia at

Monday, 5 August 2019

Latest MRG Publications

And another batch of publications from the Musculoskeletal Research Group

1.A two-phase cohort study of the sleep phenotype within primary Sjögren's syndrome and its clinical correlates.
Lewis I, Hackett KL, Ng WF, Ellis J, Newton JL.
Clin Exp Rheumatol. 2019 Jul 15. [Epub ahead of print]
PMID: 31365332 [PubMed - as supplied by publisher]
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2.IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.
Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG.
Front Immunol. 2019 Jul 3;10:1535. doi: 10.3389/fimmu.2019.01535. eCollection 2019.
PMID: 31333666 [PubMed - in process] Free PMC Article
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3.Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.
Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D'Agostino MA, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Östor A, Raza K, Taylor PC, van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP.
Trials. 2019 Jul 15;20(1):429. doi: 10.1186/s13063-019-3403-7.
PMID: 31307535 [PubMed - in process] Free PMC Article
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4.Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.
Baker KF, Skelton AJ, Lendrem DW, Scadeng A, Thompson B, Pratt AG, Isaacs JD.
J Autoimmun. 2019 Jul 4. pii: S0896-8411(19)30196-9. doi: 10.1016/j.jaut.2019.06.009. [Epub ahead of print]
PMID: 31280933 [PubMed - as supplied by publisher] Free Article
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Monday, 20 May 2019


Including Nicola Smith on Paediatric Musculoskeletal Care...




ICM Research in Progress Seminar

Monday 20th May


Anastasia Resteu

(Dr Venetia Bigley, Prof Matthew Collin, Dr Roman Bauer)

Differential IRF8 requirement defines two pathways of dendritic cell development in vivo

Dendritic cells (DCs) are specialised antigen-processing and presenting cells with critical roles in the regulation of immunity. Human DC subsets develop in the bone marrow under the control of specific transcription factors, mutation of which can result in dendritic cell immunodeficiency in humans. However, how human DCs develop from haematopoietic stem cells is not well mapped.

Single cell transcriptomics, combined with phenotyping and in vitro culture of healthy controls were used to define two distinct pathways of DC development. Their differential requirement for transcription factor IRF8 was interrogated through the analysis of a unique series of patients with IRF8 mutations.


Nicola Smith

(Prof Helen Foster)

Evaluation of Educational Resources Designed to Facilitate Access to Care for Children with Musculoskeletal Conditions

Children with musculoskeletal diseases have a delay in access to specialist care, with impact on quality of life, development and long term outcomes. If we are to achieve our goal of raising awareness and early recognition of rheumatic disease in childhood through education, we need to understand if, and how, our e-resources lead to change in clinical practice. Our work focuses on developing and piloting an evaluation strategy of the e-resources in real-time, across the stakeholder groups, in order to allow iterative development, optimise uptake and gain insights on impact.


Chair: Henrique De Paula Lemos Dental Lecture Theatre D

1pm - 2pm


Monday, 1 April 2019

NIHR Trial of Pediatric Tools

Here it is! 

As featured in the NIHR Newsletter - the pgalsplus trial.