Institute Research Student Seminars
Speakers: Scott Anderson, PhD student (Diabetes), Sophie Cassidy, PhD student (Diabetes) Fahad Ahmed, PhD student
Date and time: Wednesday 30 April 2014 at 1.00pm
Scott Anderson will present:
“Targeting islet inflammation ex vivo and following transplantation”
Type 1 diabetics, who have lost sensitivity to exogenous insulin, are prone to life threatening bouts of hypoglycaemia. Islet transplantation offers a possible therapy to rectify these life threatening episodes. Current islet transplant outcomes are poor, with less than 10% insulin independence at year 5. Poor results are due to pre transplant stress on donor islets leading to islet death as a result of pro-inflammatory signalling. This research aims to characterise the pro-inflammatory signature in stressed human islets and a rat β cell line. Mesenchymal stem cells, in co-culture and/or co-transplant, and islet filtration will then be used to try and reduce inflammatory signalling. This research could increase the number of viable islets transplanted into recipients, increasing transplant longevity and improving glycaemic control.
Sophie Cassidy will discuss:
“The effects of high intensity intermittent training (HIIT) on cardiac function
in people with Type 2 diabetes”.
The rationale for using exercise as a therapeutic strategy for diabetic cardiomyopathy will be explored as well as an overview of the methods and results so far from my study.
Key words: Exercise, Type 2 Diabetes, Cardiac
Fahad Ahmed will speak on:
"Metformin improves endothelial progenitor cells number in Type 1 diabetes"
Cardiovascular disease (CVD) remains the main cause of morbidity and mortality in diabetic patients. Metformin has been shown to have cardiovascular benefits in type 2 diabetes. However, this effect has not been studied in type 1 diabetes (T1DM). Our work, whilst controlling for glucose changes, explores, if metformin has cardiovascular benefits in T1DM by studying cardiovascular surrogate outcomes - circulating endothelial progenitor cells (EPC). EPCs are involved in vascular regeneration and/or predict development of atherosclerotic CVD.
Keywords: Type 1 diabetes mellitus, metformin, endothelial progenitor cells and endothelial dysfunction
Chair: Dr Katrin Jaedicke, Research Associate