Monday 30 June 2014
Sunday 29 June 2014
July 3rd, Tessa Crompton, Hedgehog Signalling in T-Cell Differentiation
Thursday 3rd July
"Hedgehog signalling in T cell differentiation"
Please note that due to refurbishment work, Tessa's seminar will take place at 5pm in Lecture theatre G.05 in the Percy Building (opposite the Beehive Building)
Professor Tessa Crompton
Tissue-derived hedgehog proteins modulate Th differentiation and disease.
Furmanski AL, Saldana JI, Ono M, Sahni H, Paschalidis N, D'Acquisto F, Crompton T.
J Immunol. 2013 Mar 15;190(6):2641-9. doi: 10.4049/jimmunol.1202541. Epub 2013 Feb 13.
T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss.
Furmanski AL, O'Shaughnessy RF, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG, Crompton T.
J Invest Dermatol. 2013 May;133(5):1221-30. doi: 10.1038/jid.2012.492. Epub 2013 Jan 10.
Lau CI, Outram SV, Saldaña JI, Furmanski AL, Dessens JT, Crompton T.
Blood. 2012 May 17;119(20):4741-51. doi: 10.1182/blood-2011-10-387266. Epub 2012 Mar 28.
Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte.
Furmanski AL, Saldana JI, Rowbotham NJ, Ross SE, Crompton T.
Eur J Immunol. 2012 Feb;42(2):489-99. doi: 10.1002/eji.201141758. Epub 2011 Dec 16.
D'Acquisto F, Crompton T.
Biochem Pharmacol. 2011 Aug 15;82(4):333-40. doi: 10.1016/j.bcp.2011.05.019. Epub 2011 May 27. Review.
Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.
Drakopoulou E, Outram SV, Rowbotham NJ, Ross SE, Furmanski AL, Saldana JI, Hager-Theodorides AL, Crompton T.
Cell Cycle. 2010 Oct 15;9(20):4144-52. Epub 2010 Oct 27.
Maione F, Paschalidis N, Iqbal AJ, Crompton T, Perretti M, D'Acquisto F.
Autoimmunity. 2010 Dec;43(8):672-81. doi: 10.3109/08916931003678296. Epub 2010 Apr 7.
Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection.
Paschalidis N, Huggins A, Rowbotham NJ, Furmanski AL, Crompton T, Flower RJ, Perretti M, D'Acquisto F.
Cell Cycle. 2010 Feb 15;9(4):784-93. Epub 2010 Feb 17.
Furmanski AL, Bartok I, Chai JG, Singh Y, Ferreira C, Scott D, Holland SJ, Bourdeaux C, Crompton T, Dyson J.
J Immunol. 2010 Jan 15;184(2):650-7. doi: 10.4049/jimmunol.0902291. Epub 2009 Dec 7.
Furmanski AL, Crompton T.
Cell Cycle. 2009 Dec;8(23):3810. Epub 2009 Dec 1. No abstract available.
Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Rowbotham NJ, Crompton T.
J Immunol. 2009 Sep 1;183(5):3023-32. doi: 10.4049/jimmunol.0900152. Epub 2009 Aug 10.
Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism.
Rowbotham NJ, Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Dessens JT, Crompton T.
Blood. 2009 May 21;113(21):5144-56. doi: 10.1182/blood-2008-10-185751. Epub 2009 Mar 9.
Outram SV, Hager-Theodorides AL, Shah DK, Rowbotham NJ, Drakopoulou E, Ross SE, Lanske B, Dessens JT, Crompton T.
Blood. 2009 Mar 5;113(10):2217-28. doi: 10.1182/blood-2008-03-144840. Epub 2008 Dec 23.
KLF13 influences multiple stages of both B and T cell development.
Outram SV, Gordon AR, Hager-Theodorides AL, Metcalfe J, Crompton T, Kemp P.
Cell Cycle. 2008 Jul 1;7(13):2047-55. Epub 2008 May 5.
Rowbotham NJ, Furmanski AL, Hager-Theodorides AL, Ross SE, Drakopoulou E, Koufaris C, Outram SV, Crompton T.
Cell Cycle. 2008 Apr 1;7(7):904-8. Epub 2008 Jan 18.
Wednesday 25 June 2014
MRG Lab Meeting 27.6.14 Omenn Syndrome, Rheumatoid Arthritis, TNF and Chronic Fatigue Syndrome CFS
Friday 27th June 2014 at 9.00am in the Baddiley Clark Lecture Theatre.
Chair
Chun Chan – Research Associate (PI – Drew Rowan)
Speakers
Suhibala Navaneethan - MRes Student (Supervisor – Sophie Hambleton) Title of Talk "Investigating a novel genetic cause of Omenn syndrome"
Tasha Price - MRes Student (Supervisors – John Isaacs and Drew Rowan) Title of Talk "Understanding the Cellular Source of IL-6 and IL-23 in early RA"
Rachel Etherington - MRes Student (Supervisor – Anja Krippner) Title of Talk "Regulation of regulatory T cell migration in rheumatoid arthritis by TNF"
Megan Lynn - MRes Student (Supervisors - Fai Ng, Stuart Watson and Julia Newton) Title of Talk "Glucocorticoid Receptor Function in Chronic Fatigue Syndrome"
'Role of macrophages in the initiation and maintenance of fibrosis' 25 June 4pm Dental Lecture Theatre F
Faculty Lecture: 'Role of macrophages in the initiation and maintenance of fibrosis'
Wednesday 25 June 4pm, Dental Lecture Theatre F
Guest Speaker: Dr Tom Wynn, senior investigator and chief of the Immunopathogenesis Section of the Laboratory of Parasitic Disease
Biography
Dr. Wynn is a senior investigator and chief of the Immunopathogenesis Section of the Laboratory of Parasitic Disease. He also serves as the scientific director of the NIH-Oxford-Cambridge Scholars program, a doctoral training program for outstanding science students committed to biomedical research, which annually supports more than 52 doctoral candidates at NIH, Oxford University, and Cambridge University. Dr. Wynn obtained his Ph.D. from the University of Wisconsin-Madison Medical School in the department of microbiology and immunology. His laboratory group uses a variety of in vivo model systems to study the immunological mechanisms controlling chronic inflammation and fibrosis. He has published over 175 papers, reviews, and book chapters in many prestigious journals, including Nature, Nature Immunology, Journal of Experimental Medicine, Gastroenterology, Nature Reviews Immunology, Nature Medicine, and Annual Review of Immunology. He has made seminal contributions to our understanding of the role of IL-13, IL-17A, and macrophages in the progression and resolution of liver and lung fibrosis and has developed in vivo models to test novel anti-fibrotic drugs. Dr. Wynn was recently elected to fellowship in the American Academy of Microbiology and has received several prestigious awards, including the Bailey K. Ashford Medal from the American Society of Tropical Medicine and Hygiene, the Oswaldo Cruz Medal from the Oswaldo Cruz Foundation, and two Merit Awards from NIH. Dr. Wynn has organized several national and international scientific meetings, including three Keystone Symposia, and collaborates extensively with the pharmaceutical industry.
Wednesday 18 June 2014
'Role of macrophages in the initiation and maintenance of fibrosis'
Faculty Lecture: 'Role of macrophages in the initiation and maintenance of fibrosis'
Wednesday 25 June 4pm, Dental Lecture Theatre F
Guest Speaker: Dr Tom Wynn, senior investigator and chief of the Immunopathogenesis Section of the Laboratory of Parasitic Disease
Biography
Dr. Wynn is a senior investigator and chief of the Immunopathogenesis Section of the Laboratory of Parasitic Disease. He also serves as the scientific director of the NIH-Oxford-Cambridge Scholars program, a doctoral training program for outstanding science students committed to biomedical research, which annually supports more than 52 doctoral candidates at NIH, Oxford University, and Cambridge University. Dr. Wynn obtained his Ph.D. from the University of Wisconsin-Madison Medical School in the department of microbiology and immunology. His laboratory group uses a variety of in vivo model systems to study the immunological mechanisms controlling chronic inflammation and fibrosis. He has published over 175 papers, reviews, and book chapters in many prestigious journals, including Nature, Nature Immunology, Journal of Experimental Medicine, Gastroenterology, Nature Reviews Immunology, Nature Medicine, and Annual Review of Immunology. He has made seminal contributions to our understanding of the role of IL-13, IL-17A, and macrophages in the progression and resolution of liver and lung fibrosis and has developed in vivo models to test novel anti-fibrotic drugs. Dr. Wynn was recently elected to fellowship in the American Academy of Microbiology and has received several prestigious awards, including the Bailey K. Ashford Medal from the American Society of Tropical Medicine and Hygiene, the Oswaldo Cruz Medal from the Oswaldo Cruz Foundation, and two Merit Awards from NIH. Dr. Wynn has organized several national and international scientific meetings, including three Keystone Symposia, and collaborates extensively with the pharmaceutical industry.
Tuesday 17 June 2014
Rheumatoid Arthritis Pathogenesis Centre of Excellence
RACE Launch as reported in the Journal
http://www.thejournal.co.uk/news/north-east-news/newcastle-university-leading-way-research-7223919
Rheumatoid Arthritis Pathogenesis
Monday 16 June 2014
Wednesday 11 June 2014
Monday 9 June 2014
Kidney Damage, Immunological Ageing and Frontline Healthcare Quality, 11th June 2014
Institute Research Student Seminars
Speakers: Rishab Kapoor, PhD student (Transplantation), Dr Rachel Harry, Research Associate and Allison Farnworth, PhD student (Reproductive & Vascular Biology)
Venue: Seminar room L3.2, 3rd floor, William Leech Building, Medical School
Date and time: Wednesday 11 June 2014 at 1.00pm
Rishab Kapoor will present:
"The Effect of Injury on Renal Tubular Cell Phenotype"
Acute kidney injury (AKI) is a rapid loss of function often secondary to systemic disease. AKI commonly occurs when there is a reduction in renal blood flow leading to renal ischemia. This is then followed by reperfusion once blood flow is re-established. In its most extreme form no blood flows to the kidney, but more commonly there is reduced flow as seen in hypotension and hypovolaemia. The term ischaemia reperfusion injury (IRI) is used to describe this type of injury. This project involves studying the mechanisms by which renal IRI results in long-term disease.
Key words: IRI, fibrosis and hypoxia
_____________________________
Dr Rachel Harry will discuss:
"Does monoclonal antibody induced cytokine release increase with Age?"
Therapeutic antibodies are an example of immune modifying therapies which actively harness the patient immune system to mediate their effects. Administration of the first dose of therapeutic antibodies has previously been associated with a potentially fatal side effect termed a first dose-reaction. Ageing is widely acknowledged to result in changes to the immune system which may influence the efficacy and safety of therapeutic antibodies. This study aims to investigate whether monoclonal antibody induced cytokine production is affected by the age of an individual.
Key words: Therapeutic Antibodies, Ageing, Cytokines.
_____________________________
Allison Farnworth will speak on:
"If you can get away with a silver service, why go for a platinum service? Exploring the way in which frontline NHS staff decides when health care quality is "good enough""
Quality in health care is important. It has been suggested NHS frontline staff should play a key role in defending and improving the quality of the services they provide. This qualitative study explores factors which impact on (a) the ways in which health care professionals define quality of care and (b) the extent they are willing to accept quality which they think could/should be better.
Keywords: Health services research, qualitative methodology and health care quality
Chair: Darren Johnson, PhD student (Dermatology)
Monday 2 June 2014
BIOINFORMATICS & SYSTEMS BIOLOGY SEMINAR - David Westhead – University of Leeds—Friday 6 June @ 1 pm, Research Beehive room 2.21
David Westhead – University of Leeds—Friday 6 June @ 1.15 pm, Research Beehive room 2.21
"High-throughput data, bioinformatics and its application to normal and aberrant genetic regulation in blood cells"
High-throughput sequencing has revolutionised our ability to generate data relevant to genetic regulation. I will discuss recent work we have been doing to integrate expression data (RNA-seq) with ChIP-seq data for transcription factor binding and chromatin marking in order to understand the genetic regulation of blood cell (myeloid) development. I will also discuss our work on aberrant regulation in leukaemia and how we are starting to translate this work into the clinic.
http://www.fbs.leeds.ac.uk/staff/profile.php?un=bmbdrw
Faculty contact: Diego Miranda-Saavedra (diego.miranda-saavedra@ncl.ac.uk), ext. 8590
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