Thursday 30 June 2016

Juvenile Idiopathic Arthritis






VIVA Seminar

Speaker: Mary Brennan

Supervisors: Professor Helen Foster
        Dr Tim Rapley
           Dr Jane Stewart


Title: Establishing clinical networks to deliver optimal care for children and young people with Juvenile Idiopathic Arthritis - guidance for medical professionals

Key words: Qualitative Research,Clinical Networks, Education & Training, Organisational Change


Date & time: Friday 1st July 2016 at 11:00 am

Venue: Room M4.064c, MRG meeting room








Help I'm Ageing!

Thursday 23 June 2016

Wednesday 22 June 2016

Another batch of promising talks...

The MRG Lab Meeting will be taking place on Friday 24th June 2016 at 9.00am in the Baddiley Clark Seminar Room. 

Joe Willet (Research Associate - Supervisor - Sophie Hambleton)
Alex Clark (MRes/PhD Student - Supervisor - Arthur Pratt) Title of Talk "Characterisation of CD4+ Lymphocyte eQTLs in early arthritis patients"
Alvin Lakmudin (MRes Student - Supervisor - David Young) Title of Talk “miRNA inhibition vs CRISPR-Cas9 mediated deletion: the role of mirna 455 in chondrocytes”
Will Thompson (MRes/PhD Student – Supervisors - John Loughlin, Louise Reynard and Catharien Hilkens) "Do Rheumatoid Arthritis Risk Loci Drive GM-CSF Expression in CD4 T cells?"


Mesenchymal stromal cells for arthritis repair






VIVA Seminar

Speaker: Sylvia Muller

Supervisors: Professor Anne Dickinson

             Dr Xiao Nong Wang

        Dr Julian De Havilland


Title: A study of mesenchymal stromal cells for arthritis repair

Key words: Mesenchymal stromal cells, osteoarthritis, tissue engineering, ceramic scaffolds


Date & time: Friday 24th June 2016 at 10:00 am

Venue: Seminar Room 1.58 (Ground Floor, Ridley Building 2)









Monday 20 June 2016

Scientific Images

Just one of the images from the Scientific Images competition on D Day...



Friday 17 June 2016


We're off to the ICM Director's Day to catch up on the latest research.  Everything from rheumatoid arthritis through osteoarthritis to breast cancer and diabetes by way of periodontitis and paediatric immunology.  Should be good!

Microbiome Talk




PI Seminar Series


Speaker:      Dr Christopher J Stewart, Baylor College of Medicine, Houston, TX

Venue:      Baddiley Clark Seminar Room

Date:          20th June 2016

Time:               13.00-14.00


Dr Chris Stewart will present:


‘Exploring preterm gut microbiome development and host responses using multi-omic approaches’




The developing gut microbiome is highly dynamic in early life and is critical for a range of health and disease outcomes through infancy and into childhood including obesity, allergy, cardiovascular health, and cognition. In infants born preterm (<10% of all births), microbial acquisition is abnormal and affected by a complex exposome including delivery mode (e.g. C-section), environment (humidified incubators), nutritional interventions (breast milk) and frequent use of broad-spectrum antibiotics.  Emerging data show close associations between patterns of colonization in preterm infants and devastating diseases such as necrotising enterocolitis (NEC) and late onset sepsis (LOS). Together these key pathologies are responsible for more childhood deaths than all leukaemia and lymphoma combined, and survivors suffer significant long-term physical and cognitive morbidity.  However, progress toward understanding of the basic mechanisms linking development of the gut microbiome to host responses in early life are limited.


Our research efforts have focused on comprehensively characterizing microbial and host development in preterm infants in early life. To this end we have utilized a range of powerful high-throughput technologies combining next generation sequencing, proteomics, and metabolomics. Integrated analysis from these ‘omic based techniques have demonstrated high concordance between bacterial abundance and host metabolism. We further show NEC is a disease without a clear causative microbial signature, although a community abundant in bifidobacteria may protect preterm infants from NEC and LOS. Ongoing research interests are focused on translating and validating the findings from these discovery driven experiments using novel ex vivo human intestinal enteroid models, as well as creating a bio-repository of deeply phenotyped samples collected within controlled trials for future study.


Chair: Dr Chris Lamb


Friday 3 June 2016

PMM Thailand - Exchanging Contracts

Our very own Prof Helen Foster exchanging contracts with our very first global partner in the Paediatric Musculoskeletal Matters project.

Thursday 2 June 2016

Immune Reprogramming

 This should be good...



PI Seminar Series



Speaker:      Professor Herman Waldmann FRS, FMedSci,

            Professor of Pathology,

Sir William Dunn School of Pathology, Oxford


Venue:      Baddiley Clark Seminar Room

Date:                     6th June 2016

Time:               13.00-14.00



Professor Waldmann will present:


‘Mechanisms underlying therapeutic tolerance’




A major goal in immunosuppressive therapy is to provide short-term therapy to achieve long-term benefit.


This has been possible in mouse models using monoclonal antibody intervention.


Here I will summarise what we know about the mechanisms underlying such immune reprogramming with some emphasis on the roles of TGFbeta in the process.




Chair: Professor Andrew Mellor