Biologics and Biosimilars

John Isaacs shares his thoughts on Biologics and Biosimilars

MRG LAB MEETING 29.11.13

Seminar Room of the Baddiley Clark Building on Friday 29th November 2013 at 9.00am. 

 

Chair

 

Jie Zheng (PhD Student - PI Desa Lilic)

 

Speakers

 

Chris Tibbitt (PhD Student - PIs Cat Hilkens/John Robinson/Jane Falconer) Title of talk "Does strength of T cell receptor signalling regulate T helper-17 (Th17) responses in autoimmune arthritis?"

 

Marzena Ciechomska (Post Doc - PI Jaap van Laar) Title of Talk "Anti-fibrotic role of miR-29a in pathogenesis of systemic sclerosis"

 

Amy Anderson (Research Associate - PI John Isaacs) Title of Talk "Biomarkers in early rheumatoid arthritis"

 

 

 

 

ICM Guest Seminar, Wednesday 27 November 2013

 

Institute Research Seminar

 

Guest speaker: Dr Arian Laurence

[National Institute of Arthritis and Musculoskeletal & Skin Diseases, NIH, USA]

 

Venue: Seminar room L2.6, 2^nd floor, Leech Building, Medical School

Date and time:  Wednesday 27 November 2013 at 12.00 noon

 

Dr Laurence will discuss:

 

"Epithelial and haematopoetic STAT3 is required for antibacterial defence

in a mouse model of HIES."

 

Autosomal dominant Hyper IgE syndrome is an immunodeficiency associated with mutations in STAT3. To dissect the importance of STAT3 in haematopoietic and non-haematopoietic cells we generated a mouse model of this disease. These animals recapitulate multiple aspects of HIES including susceptibility to bacterial infections that was only partially corrected by bone marrow transplantation, emphasising the role played by the epithelium in the pathophysiology of HIES.

 

 

Key words:  HIES (Hyper Ig E syndrome), IL-17, IL-22, STAT3

 

_______________________

 

Arian is a UK-trained haematologist and current postdoctoral member of John O'Shea's group at NIH, working on the role of STAT3 and STAT5 signaling in T cells.  He will be in Newcastle all day on the 27^th - please contact Sophie Hambleton (sophie.hambleton@ncl.ac.uk) if you would like an opportunity to talk with him.

 

Chair:  Dr Sophie Hambleton

 

 

 

ICM Research Seminars, Wednesday 27 November 2013, 1.00pm

 

Institute Research Student Seminars

Speakers:  Katie Griffiths, PhD student (Diagnostics), Richard Speight, MD student (Transplantation) and Victoria Whittle, MD student (Musculoskeletal)

Venue: Seminar room L2.5, 2^nd floor, Leech Building, Medical School

Date and time:  Wednesday 27 November 2013 at 1.00pm

 

Katie Griffiths will present:

 

"Laser Scribed Graphene as an electrode for sensing."

 

Light scribe technology has been used as a simple and inexpensive solution for manufacturing graphene electrodes for use in electrochemistry with the aim of developing novel biosensors.

Key words:  Graphene, biosensors, electrochemistry

____________________________

Richard Speight will discuss:

 

'Inflammatory Bowel Disease: Is it all about bile in the small bowel?'

 

Recent evidence demonstrates that bile acids are more than mere detergent molecules with

evidence that they have an immune regulatory role.  My MD is attempting to unravel how bile acid dysmetabolism may be implicated in IBD.

 

Key words:  bile acids, IBD, FXR

_____________________________

Victoria Whittle will talk about:

 

"Practicing Medicine."

 

Exploring the impact of an Acute Care, High-fidelity Simulation teaching programme

delivered to final year medical undergraduates.

 

Keywords: Medical education, Simulation, Acute Care

 

Chair:  Catriona Barker, PhD student (Transplantation)

 

 

 

 

Prof Drew Rowan is our expert at the Arthritis Research UK Christmas event.

Our 'Meet the Expert' Christmas event is at Durham County Cricket Club on 12/12/13. Find out how to register here http://bit.ly/1876ja9

ICM Student Seminars - Wednesday, 20th November, 2013

Everyone is very welcome to attend the seminars being given today at 1.00pm in seminar room L2.3, 2nd floor, Leech Building by ICM PhD students Keith Wu (Dermatology), Eirini Giannoudaki (Immunology/Transplantation) and Teresa Kelly (Reproductive & Vascular Biology).

 

UK Molecular Epidemiology Group, 6th December 2013

UK Molecular Epidemiology Group Winter Meeting  - 6^th December 2013 -  further details

Research Student Seminars, Wednesday, 20th November, 1.00pm

Institute Research Student Seminar  - Wednesday 20 November 2013 at 1.00pm Seminar room L2.3, 2nd floor, Leech Building, Medical School

·        Keith Wu: "Investigating the role of epigenetics in the control of inflammatory skin disease."

·        Eirini Giannoudaki: "The role of sphingosine 1-phosphate in ischemia-reperfusion injury."

·        Teresa Kelly: "Optimising Baby to Breast Attachment (OBBA): a feasibility randomised controlled trial".

Arthritis Demographic Data

See the latest UK demographic data and statistics:

http://www.arthritisresearchuk.org/arthritis-information/data-and-statistics.aspx

Immunodeficiency and Early Inflammatory Arthritis

Seminar Room of the Baddiley Clark Building on Friday 15th November 2013 at 9.00am. 

 

Chair

 

Jessica Tarn (PhD Student - PIs Fai Ng/David Young)

 

Speakers

 

Nic Robertson (Academic Foundation Doctor - PI Sophie Hambleton)

Title of talk "Investigating mutations in NUDCD3 as a possible cause of immunodeficiency"

 

John-Paul Doran (Clinical Research Fellow - PI John Isaacs)

Title of Talk "Biomarkers in Early Inflammatory Arthritis"

 

Erik Gocker: immunodeficiency, autoimmunity, colitis, IL-10

Institute Research Seminar

 

Guest speaker: Dr Erik Glocker

[Department of Medical Microbiology and Hygiene, University Hospital, Freiburg]

 

Venue: Dental lecture theatre E, ground floor, Dental School

Date and time:  Wednesday 13 November 2013 at 4.00pm

 

Dr Glocker will discuss:

 

“Key players for intestinal immune homeostasis.”

 

Key words: immunodeficiency, autoimmunity, colitis, IL-10

 

Sandy Tse: Cartilage Resorption in Osteoarthritis

Institute Research Student Seminars

Speakers:  Sandy Tse, PhD student,

 

Venue: Seminar room L2.3, 2^nd floor, Leech Building, Medical School

Date and time:  Wednesday 13 November 2013 at 1.00pm

 

 

“Investigating the novel serine proteinase SPUVE and its role in cartilage resorption

in osteoarthritis.”

 

The aim of this project is to fully characterise the trypsin-like serine proteinase SPUVE (also known as PRRS23).  SPUVE is predicted to promote cartilage resorption in osteoarthritis since it is one of the most significantly up-regulated genes in cartilage from OA patients compared to non-diseased cartilage.

 

Oxford Book of Rheumatology

Congratulations to Helen Foster and John Isaacs' on their contribution to the Fourth Edition of the Oxford Book of Rheumatology.

http://ukcatalogue.oup.com/product/9780199642489.do#

Early Diagnosis = Better Prognosis?

Arthritis Research UK recommend people visit their GP as an early diagnosis can make a big difference. May be useful: http://bit.ly/140OnOP

TNF co-stimulated T-lymphocytes in systemic sclerosis

And another paper to celebrate:

 

Hügle T, O’Reilly S, Simpson R, Kraaij M, Bigley V, Collin M, Krippner-Heidenreich A, van Laar J: Tumour necrosis factor co-stimulated T-lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts, Arthritis Rheum. 2013, 65, p481.

 

Latest Awards

Recent Awards:

 

ANJA - JGWP Foundation grant: dissection of tNF-mediated regulatory T cells functions: Differential TNF receptor signalling as potential predictor for anti-TNF responders and non-responders in RA (£36 000 includes technical assistant for 12 months).   

JDI - MICA: Targeting the RA synovial fibroblast via cyclin dependent kinase inhibition - a phase IIa study (£1.1 Million).

Drew - JGW Patterson Foundation Grant: The role of non-catalytic protein domains of matriptase in cartilage catabolism. £50,000.

 

Welcome to the MRG

And a warm welcome to our new starters!

 

Marilena Padsalidou       – RT – Anja

Joe Willet                            – RA  - Sophie

Karin Engelhardt               – RA  - Sophie

David Swan                         – RA  - Sophie

Ken Baker                           – PhD Student – John Isaacs

Natasha Price                    – MRes/PhD Student – John Isaacs & Drew

David Hodgson                  – MRes/PhD Student – Carol & Drew

Chun Chang                        – RA  - Drew

Craig Bullock                       – JRA  - Drew

 

More Publications from MRG

Maas C, Tromp JM, van Laar J, Thijssen R, Elias JA, Malara A, Krippner-Heidenreich A, Silke J, van Oers MH, Eldering E: CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex, Cell Death Dis. 2013 Aug 29;4:e782.

 

Rensing-Ehl A, Janda A, Lorenz MR, Gladstone BP, Fuchs I, Abinun M, Albert M, Butler K, Cant AJ, Cseh AM, Ebinger M, Goldacker S, Hambleton S, Hebart H, Houet L, Kentouche K, Kühnle I, Lehmberg K, Mejstrikova E, Niemeyer C, Minkov M, Neth O, Dückers G, Owens S, Roesler J, Schilling FH, Schuster V, Seidel MG, Smisek P, Sukova M, Svec P, Wiesel T, Gathmann B, Schwarz K, Vach W, Ehl S, Speckmann C. Sequential decisions on FAS sequencing guided by biomarkersin patients with lymphoproliferation and autoimmune cytopenia. Haematologica. 2013 Jul 19. [Epub ahead of print] 

 

Slatter M, Nademi Z, Patel S, Barge D, Valappil M, Brigham K, Hambleton S, Clark J, Flood T, Cant A, Abinun M, Gennery A. Haploidentical hematopoietic stem cell transplantation can lead to viral clearance in severe combined immunodeficiency. J Allergy Clin Immunol. 2013 Jun;131(6):1705-8. doi: 10.1016/j.jaci.2013.03.036. 

 

Pratt AG, Lorenzi AR, Wilson G, Platt PN, Isaacs JD. Predicting persistent inflammatory arthritis amongst early arthritis clinic patients in the UK: is musculoskeletal ultrasound required? Arthritis Research and Therapy 2013: in press

 

BSR Abstracts Deadline - 15th November 2013

Please note that the deadline for abstract submission to next year’s BSR is 15^th November.

 

Plenty of prizes on offer (eg young investigator awards): http://www.rheumatology.org.uk/about_bsr/press_releases/over_20k_of_awards.aspx?utm_source=BSR+e-newsletter+recipients&utm_campaign=514a9b7b43-BSR+e-News+4+July&utm_medium=email&utm_term=0_af7b6bb546-514a9b7b43-334865897

 

Infection, Immunity and Inflammation

Just to remind you that this Thursday, 7th November at 5pm in room 2.21 of the Research Beehive (refreshments available from 4.30pm) 

 

Prof. Jim Brewer from the Institute of Infection, Immunity and Inflammation, University of Glasgow will be speaking on:

 

"Imaging infection and immunity in vivo."

 

Jim’s research interests are listed on his lab. web page (below) and I have listed some of his recent publications fyi.

 

http://www.gla.ac.uk/researchinstitutes/iii/staff/jamesbrewer/

 

 

ICM Research Seminar - Intestinal Immune Homeostasis

 

Guest speaker: Dr Erik Glocker

[Department of Medical Microbiology and Hygiene, University Hospital, Freiburg]

 

Venue: Dental Lecture Theatre E, Ground Floor, Dental School

Date and time:  Wednesday 13 November 2013 at 4.00pm

 

Dr Glocker will discuss:

 

“Key players for intestinal immune homeostasis.”

 

Key words: immunodeficiency, autoimmunity, colitis, IL-10

 

Dr Glocker is a medical microbiologist who unravelled the critical role of IL-10 and IL-10 receptor deficiency in inflammatory bowel disease.

He also published the first report on the role of CARD9 in mucocutaneous and systemic fungal immunity.

 

Chair:  Dr Desa Lilic