Tuesday 29 November 2016

Coming Soon! Therapeutic Tolerance Workshop 27-30th June 2017


Therapeutic Tolerance Workshop 27-30th June 2017


Confirmed speakers

R Germain (Bethesda, USA)

Keynote address: Imaging the immune system


G Hollander (Oxford, UK)

The thymus – an update


E Shevach (Bethesda, USA)

Regulatory T cells


F Powrie (Oxford, UK)

Manipulating the microbiome for tolerance induction


D Sansom (London, UK)

What does CTLA4 really do?


S Khleif (Augusta, USA)

Title TBC


T Johnson (Augusta, USA)

Trials and tribulations in breaking tumour tolerance


PP Tak (Stevenage, UK)

Immunomodulation by vagal nerve stimulation


H Jonuleit (Mainz, Germany)

Tolerogenic targets in regulatory T cells


I Anegon (Nantes, France)

Novel mechanisms in tolerance induction


J Isaacs (Newcastle, UK)

Update on the RA-MAP consortium


M Hernandez-Fuentes (London, UK)

Biomarkers in transplantation tolerance


G Kassiotis (London, UK)

Endogenous retroviruses and the breakdown of immune tolerance


G Lombardi (London, UK)

Tregs in kidney transplantation


R Thomas (Brisbane Australia)

A platform for peptide therapeutics


G Schett (Erlangen, Germany)

Autoantibodies as tolerance biomarkers


M Trucco (Pittsburgh, USA)

Tolerogenic therapies for type I diabetes


A Cope (London, UK)

Treating very early autoimmunity


M Rosenzwajg (Paris, France)

Low dose IL-2 therapy

L Chatenoud (Paris, France)

Anti-CD3 – an update


A Coles (Cambridge, UK)

Alemtuzumab in Multiple Sclerosis


M Ehrenstein (London, UK)

Anti-TNF as a tolerogenic therapy


A Mellor (Newcastle, UK)

IDO and tolerance – where are we now?


D Howie (Oxford, UK)

How FoxP3 regulates immune metabolism


L Graca (Lisbon, Portugal)

Tolerance to Factor VIII


H Waldmann (Oxford, UK)

Novel antibodies with improved properties?


J van Laar (Utrecht, The Netherlands)

Hematologic transplantation as a therapy for autoimmunity


A Radbruch (Berlin, Germany)

Restoring B cell tolerance


F van Wijk (Utrecht, The Netherlands)

Resetting T cell regulation in JIA


M Bernardo (Milan, Italy)

Mesenchymal for tolerance induction


D Wraith (Birmingham, UK)

Peptide therapy in MS and other conditions


L Klareskog (Stockholm, Sweden)

Evolution of an autoimmune disease


P Trzonkowski (Gdansk, Poland)

Treg therapies in type I diabetes


C Mauri (London, UK)

Regulator B Cells


K Kishimoto (Massachusetts , USA)

Tolerogenic nanoparticles


R Wilkinson (Cambridge, UK)

Title TBC


D Vignali (Pittsburgh, USA)

Title TBC


M Peakman (London, UK)

Peptide therapy in diabetes


Wednesday 23 November 2016

Chondrocytes and Mass Spec Double Bill Special :-)

The MRG Lab Meeting will be taking place on Friday 25th November 2016 at 9.00am in the Baddiley Clark Seminar Room.
Sarah Rice (Research Associate - Supervisors John Loughlin/Louise Reynard)
Matt Barter (Research Associate - Supervisor - David Young) Title of Talk "lncRNA ROCR regulates SOX9 expression and chondrocyte development"
Edith Serrano (Research Associate - Supervisor - John Isaacs) Title of Talk "SWATH-Mass Spectrometry as a tool for the identification of RA biomarkers"

Tuesday 22 November 2016


Welcome to:

Joseph Dudman (PhD Student - PI Kenny Dalgarno) Start Date 22.09.16

Benjamin John Thompson (PhD Student - PI Sophie Hambleton) Start Date 26.09.16

Leonie Schittenhelm (new RACE PhD Student - Catharien Hilkens) 26.09.16

Niloufar Hojatoleslami (PhD Student - PI Kenny Dalgarno) Start Date 28.09.16

Kegan McColgan-Bannon (PhD Researcher - PI Kenny Dalgarno) Start Date 01.10.16

Kamran Ali Mirza (Research Associate for PSS Research - PI Fai Ng) Start Date 01.10.16

Sakura Brandi (BSc/MSci Student for PSS Research – PI Fai Ng) Start Date 01.10.16

Harrison Threadgold (MSci Biomedical Sciences – PI Kenny Dalgarno) Start Date 04.10.16

Nicole Kattner (PhD Student – PI Kenny Dalgarno) Start Date 11.10.16

Gemma Vidal (PhD Student – PI Kenny Dalgarno) Start Date 04.10.16

Adrian Falconer (Research Assistant – Drew Rowan) Start Date 02.11.16

 A sad farewell to:

Ramsey Refaie (Clinical Research Fellow - PI Catharien Hilkens) 19.10.16

Rachel Harry (Research Associate – PI John Isaacs) 31.10.16

 And widespread rejoicing at the return of Julie Diboll.

Sjogren's Syndrome Book

And congratulations to Professor Wan-Fai Ng - editor of the new book on Sjogrens Syndrome.


Buy Sjogren's Syndrome (Oxford Rheumatology Library) by Wan-Fai Ng (ISBN: 9780198736950) from Amazon's Book Store. Free UK delivery on eligible orders.

Congratulations All Around

Nadia Howard-Tripp (Clinical Research Associate - Fai Ng) won an ‘Outstanding Abstract Award’ at the Oklahoma conference (5 awarded in total of $500) for the abstract ‘Fatigue is Associated with Lower Levels of Pro-inflammatory Cytokines in Primary Sjögren’s Syndrome’, which was presented as a poster. 

Nadia Howard-Tripp also received one of five ‘Trainee Travel Awards’ ($1000) to attend this conference and present an oral abstract on ‘Clinical Phenotyping in Primary Sjögren’s Syndrome’.

Helen Hanson (Senior Research Nurse for John Isaacs) returned from her researcher visit to Holland after picking up a travel award and funding for a fellowship application.

Congratulations to Mohsen El Shahali who had a successful VIVA on Monday 24th October 2016 (Supervisors Fai Ng and Jaap van Laar)

Publication Alert!

Some more papers...

Ontology in Immunology.  C Hilkens and P Lord.  Transplantation, Vol 100, No 10 pp 2014-2015 October 2016.  doi: 10.1097/TP.0000000000001445. PubMed PMID:


Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote.  Maggi J, Schinnerling K, Pesce B, Hilkens CM, Catalán D, Aguillón JC.

Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) TCells. Front Immunol. 2016 Sep 19;7:359. PubMed PMID: 27698654.

Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4(+) T-cells partly via TGF-β1.  Anderson AE, Swan DJ, Wong OY, Buck M, Eltherington O, Harry RA, Patterson AM, Pratt AG, Reynolds G, Doran JP, Kirby JA, Isaacs JD, Hilkens CM.  Clin Exp Immunol. 2016 Sep26.doi: 10.1111/cei.12870. [Epub ahead of print] PubMed PMID: 27667787.

Use of structured musculoskeletal examination routines in undergraduate medical education and postgraduate clinical practice – a UK survey.  Kenneth F Baker, Sharmila Jandial, Ben Thompson, David Walker, Ken Taylor and Helen E Foster.  BMC Medical Education (2016) 16 pp 288

‘An investigation into the prevalence of sleep disturbances in primary Sjogren’s syndrome: A systematic review of the literature’. Hackett, K.L., Gotts, Z., Ellis, J., Deary V., Rapley, T., Ng W-F., Newton, J.L., Deane, K.H.O. (2016) Rheumatology (Oxford) (In press).

EULAR/PreS Standard and recommendations for the transitional care of your people with juvenile onset rheumatic diseases.  Seza Ozen, Helen Elisabeth Foster, Janet McDonagh, Sylvia Kamphuis, Karin B. Berggren, Philomine van Pelt, Daniel  Clemente, Carine Wouters, Jenny M. Waite-Jones, R. Tattersall, Ruth Wyllie, Simon Stones, Alberto Martini, Tamas Constantin, Susanne Schalm, Berna Fidanci, Burak Erer, Erkande Mirkaya, Loreto Carmona. annrheumdis-2016-210112.R2 (in press).