The Musculoskeletal Research Group in Newcastle is a VERY research active group publishing numerous high impact papers.  Here are some from the last five years.

Revisiting the JOQUER trial: stratification of primary Sjögren's syndrome and the clinical and interferon response to hydroxychloroquine.
Collins A, Lendrem D, Wason J, Tarn J, Howard-Tripp N, Bodewes I, Versnel MA, Gottenberg JE, Seror R, Mariette X, Ng WF.
Rheumatol Int. 2021 Jun 24. doi: 10.1007/s00296-021-04927-y. Online ahead of print.
PMID: 34165604
Paget's Disease of the Bone: Patterns of Referral to Secondary Care Following Diagnosis on X-rays.
Walker JA, Tuck SP.
Calcif Tissue Int. 2021 May;108(5):634-639. doi: 10.1007/s00223-020-00800-5. Epub 2021 Jan 2.
PMID: 33388897
Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2α in osteosarcoma and prostate carcinoma cells.
Chan CD, Haagensen EJ, Tensaout HA, Rennie KJ, Gamie Z, Barry J, Birch MA, Gerrand CH, Nisar S, Robson CN, Lunec J, Rankin KS.
Oncol Lett. 2021 Feb;21(2):158. doi: 10.3892/ol.2020.12419. Epub 2020 Dec 31.
PMID: 33552276 Free PMC article.
Validation of novel patient-centred juvenile idiopathic arthritis-specific patient-reported outcome and experience measures (PROMs/PREMs).
Lunt LE, Shoop-Worrall S, Smith N, Cleary G, McDonagh J, Smith AD, Thomson W, McErlane F.
Pediatr Rheumatol Online J. 2020 Nov 19;18(1):91. doi: 10.1186/s12969-020-00481-2.
PMID: 33213474 Free PMC article.
Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement.
Nash P, Kerschbaumer A, Dörner T, Dougados M, Fleischmann RM, Geissler K, McInnes I, Pope JE, van der Heijde D, Stoffer-Marx M, Takeuchi T, Trauner M, Winthrop KL, de Wit M, Aletaha D, Baraliakos X, Boehncke WH, Emery P, Isaacs JD, Kremer J, Lee EB, Maksymowych WP, Voshaar M, Tam LS, Tanaka Y, van den Bosch F, Westhovens R, Xavier R, Smolen JS.
Ann Rheum Dis. 2021 Jan;80(1):71-87. doi: 10.1136/annrheumdis-2020-218398. Epub 2020 Nov 6.
PMID: 33158881 Free PMC article.
Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers.
van Helvoort EM, van Spil WE, Jansen MP, Welsing PMJ, Kloppenburg M, Loef M, Blanco FJ, Haugen IK, Berenbaum F, Bacardit J, Ladel CH, Loughlin J, Bay-Jensen AC, Mobasheri A, Larkin J, Boere J, Weinans HH, Lalande A, Marijnissen ACA, Lafeber FPJG.
BMJ Open. 2020 Jul 28;10(7):e035101. doi: 10.1136/bmjopen-2019-035101.
PMID: 32723735 Free PMC article.
The risk of uveitis in patients with JIA receiving etanercept: the challenges of analysing real-world data.
Davies R, De Cock D, Kearsley-Fleet L, Southwood T, Baildam E, Beresford MW, Foster HE, Thomson W, Ramanan AV, Hyrich KL; British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study (BSPAR-ETN) and the Biologics for Children with Rheumatic Diseases (BCRD) study.
Rheumatology (Oxford). 2020 Jun 1;59(6):1391-1397. doi: 10.1093/rheumatology/kez449.
PMID: 31605484 Free PMC article.
Objectively-measured sedentary time, habitual physical activity and bone strength in adults aged 62 years: the Newcastle Thousand Families Study.
Hind K, Hayes L, Basterfield L, Pearce MS, Birrell F.
J Public Health (Oxf). 2020 May 26;42(2):325-332. doi: 10.1093/pubmed/fdz029.
PMID: 31220295
Frequency of biologic switching and the outcomes of switching in children and young people with juvenile idiopathic arthritis: a national cohort study.
Kearsley-Fleet L, Heaf E, Davies R, Baildam E, Beresford MW, Foster HE, Southwood TR, Thomson W, Hyrich KL; BCRD and BSPAR-ETN study groups.
Lancet Rheumatol. 2020 Mar 9;2(4):e217-e226. doi: 10.1016/S2665-9913(20)30025-4. eCollection 2020 Apr.
PMID: 32280951 Free PMC article.
Serum CXCL13 levels are associated with lymphoma risk and lymphoma occurrence in primary Sjögren's syndrome.
Traianos EY, Locke J, Lendrem D, Bowman S, Hargreaves B, Macrae V; UK primary Sjögren’s syndrome registry, Tarn JR, Ng WF.
Rheumatol Int. 2020 Apr;40(4):541-548. doi: 10.1007/s00296-020-04524-5. Epub 2020 Feb 11.
PMID: 32047959 Free PMC article.
Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission.
Baker KF, Thompson B, Lendrem DW, Scadeng A, Pratt AG, Isaacs JD.
Ther Adv Musculoskelet Dis. 2020 May 11;12:1759720X20915322. doi: 10.1177/1759720X20915322. eCollection 2020.
PMID: 32523635 Free PMC article.
Can quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis?
Bennett JL, Wood A, Smith N, Mistry R, Allen K, Jandial S, Tuckett JD, Gowdy SC, Foster HE, McErlane F, Hollingsworth KG.
Pediatr Rheumatol Online J. 2019 Nov 21;17(1):74. doi: 10.1186/s12969-019-0377-7.
PMID: 31752877 Free PMC article.
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.
Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D'Agostino MA, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Östor A, Raza K, Taylor PC, van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP.
Trials. 2019 Jul 15;20(1):429. doi: 10.1186/s13063-019-3403-7.
PMID: 31307535 Free PMC article.
Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.
Baker KF, Skelton AJ, Lendrem DW, Scadeng A, Thompson B, Pratt AG, Isaacs JD.
J Autoimmun. 2019 Dec;105:102298. doi: 10.1016/j.jaut.2019.06.009. Epub 2019 Jul 4.
PMID: 31280933 Free PMC article.
Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.
Iqbal K, Lendrem DW, Hargreaves B, Isaacs JD, Thompson B, Pratt AG.
Rheumatology (Oxford). 2019 Jul 1;58(7):1268-1273. doi: 10.1093/rheumatology/kez008.
PMID: 30753709
Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.
Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG.
Rheumatology (Oxford). 2019 Jul 1;58(7):1250-1258. doi: 10.1093/rheumatology/kez003.
PMID: 30753680 Free PMC article.
Fatigue in primary Sjögren's syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study.
Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D; UK Primary Sjögren’s Syndrome Registry, Ng WF.
Rheumatol Int. 2019 Nov;39(11):1867-1873. doi: 10.1007/s00296-019-04354-0. Epub 2019 Jun 27.
PMID: 31250166 Free PMC article.
Quantitative Computed Tomography (QCT) of the Distal Forearm in Men Using a Spiral Whole-Body CT Scanner - Description of a Method and Reliability Assessment of the QCT Pro Software.
Hanusch BC, Tuck SP, Mekkayil B, Shawgi M, McNally RJQ, Walker J, Francis RM, Datta HK.
J Clin Densitom. 2020 Jul-Sep;23(3):418-425. doi: 10.1016/j.jocd.2019.05.005. Epub 2019 May 17.
PMID: 31160147
A two-phase cohort study of the sleep phenotype within primary Sjögren's syndrome and its clinical correlates.
Lewis I, Hackett KL, Ng WF, Ellis J, Newton JL.
Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):78-82. Epub 2019 Jul 15.
PMID: 31365332
Methotrexate persistence and adverse drug reactions in patients with juvenile idiopathic arthritis.
Kearsley-Fleet L, Vicente González L, Steinke D, Davies R, De Cock D, Baildam E, Beresford MW, Foster HE, Southwood TR, Thomson W, Hyrich KL; Biologics for Children with Rheumatic Diseases (BCRD) Study and the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study (BSPAR-ETN).
Rheumatology (Oxford). 2019 Mar 8;58(8):1453-8. doi: 10.1093/rheumatology/kez048. Online ahead of print.
PMID: 30851113 Free PMC article.
Design of experiments and the virtual PCR simulator: An online game for pharmaceutical scientists and biotechnologists.
Fellermann H, Shirt-Ediss B, Kozyra J, Linsley M, Lendrem D, Isaacs J, Howard T.
Pharm Stat. 2019 Jul;18(4):402-406. doi: 10.1002/pst.1932. Epub 2019 Feb 21.
PMID: 30793474 Free PMC article. No abstract available.
Use and effectiveness of rituximab in children and young people with juvenile idiopathic arthritis in a cohort study in the United Kingdom.
Kearsley-Fleet L, Sampath S, McCann LJ, Baildam E, Beresford MW, Davies R, De Cock D, Foster HE, Southwood TR, Thomson W, Hyrich KL.
Rheumatology (Oxford). 2019 Feb 1;58(2):331-335. doi: 10.1093/rheumatology/key306.
PMID: 30358861 Free PMC article.
Supervised walking improves cardiorespiratory fitness, exercise tolerance, and fatigue in women with primary Sjögren's syndrome: a randomized-controlled trial.
Miyamoto ST, Valim V, Carletti L, Ng WF, Perez AJ, Lendrem DW, Trennel M, Giovelli RA, Dias LH, Serrano ÉV, Subtil AM, Abreu VC, Natour J.
Rheumatol Int. 2019 Feb;39(2):227-238. doi: 10.1007/s00296-018-4213-z. Epub 2019 Jan 2.
PMID: 30604204 Clinical Trial.
Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4+ T Cells in a Murine Arthritis Model.
Jansen MAA, Spiering R, Ludwig IS, van Eden W, Hilkens CMU, Broere F.
Front Immunol. 2019 Aug 28;10:2068. doi: 10.3389/fimmu.2019.02068. eCollection 2019.
PMID: 31555285 Free PMC article.
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.
Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG.
Front Immunol. 2019 Jul 3;10:1535. doi: 10.3389/fimmu.2019.01535. eCollection 2019.
PMID: 31333666 Free PMC article. Clinical Trial.
Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome.
Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S, Bowman S, Price EJ, Pease C, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Vadivelu S, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Lendrem DW, Ng WF.
RMD Open. 2019 Apr 24;5(1):e000885. doi: 10.1136/rmdopen-2018-000885. eCollection 2019.
PMID: 31168409 Free PMC article.
Managing fatigue in patients with primary Sjögren's syndrome: challenges and solutions.
Miyamoto ST, Lendrem DW, Ng WF, Hackett KL, Valim V.
Open Access Rheumatol. 2019 Apr 24;11:77-88. doi: 10.2147/OARRR.S167990. eCollection 2019.
PMID: 31118841 Free PMC article. Review.
Developing a toolkit for the assessment and monitoring of musculoskeletal ageing.
Kemp GJ, Birrell F, Clegg PD, Cuthbertson DJ, De Vito G, van Dieën JH, Del Din S, Eastell R, Garnero P, Goljanek-Whysall K, Hackl M, Hodgson R, Jackson MJ, Lord S, Mazzà C, McArdle A, McCloskey EV, Narici M, Peffers MJ, Schiaffino S, Mathers JC.
Age Ageing. 2018 Sep 1;47(suppl_4):iv1-iv19. doi: 10.1093/ageing/afy143.
PMID: 30203052 Free PMC article. Review.
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.
Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M, Plant D, Colombo M, Orchard P, Twigg S, McInnes IB, Porter D, Freeston JE, Nam JL, Cordell HJ, Isaacs JD, Strathdee JL, Arnett D, de Hair MJH, Tak PP, Aslibekyan S, van Vollenhoven RF, Padyukov L, Bridges SL, Pitzalis C, Cope AP, Verstappen SMM, Emery P, Barnes MR, Agakov F, McKeigue P, Mushiroda T, Kubo M, Weinshilboum R, Barton A, Morgan AW, Barrett JH; MATURA; and PAMERA; Consortia.
Pharmacogenomics J. 2018 Jul;18(4):528-538. doi: 10.1038/s41397-018-0025-5. Epub 2018 May 25.
PMID: 29795407 Review.
Systemic interferon type I and type II signatures in primary Sjögren's syndrome reveal differences in biological disease activity.
Bodewes ILA, Al-Ali S, van Helden-Meeuwsen CG, Maria NI, Tarn J, Lendrem DW, Schreurs MWJ, Steenwijk EC, van Daele PLA, Both T, Bowman SJ, Griffiths B, Ng WF; UK Primary Sjögren’s Syndrome registry, Versnel MA.
Rheumatology (Oxford). 2018 May 1;57(5):921-930. doi: 10.1093/rheumatology/kex490.
PMID: 29474655
Experience of sleep disruption in primary Sjögren's syndrome: A focus group study.
Hackett KL, Deary V, Deane KH, Newton JL, Ng WF, Rapley T.
Br J Occup Ther. 2018 Apr;81(4):218-226. doi: 10.1177/0308022617745006. Epub 2018 Jan 11.
PMID: 29657352 Free PMC article.
Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren's syndrome: examination of data from the UK Primary Sjögren's Syndrome Registry.
Dumusc A, Ng WF, James K, Griffiths B, Price E, Pease C, Emery P, Lanyon P, Jones A, Bombardieri M, Sutcliffe N, Pitzalis C, Gupta M, McLaren J, Cooper A, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Barone F, Fisher B, Rauz S, Richards A, Bowman S.
Swiss Med Wkly. 2018 Feb 7;148:w14588. doi: 10.4414/smw.2018.14588. eCollection 2018.
PMID: 29442344
Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].
Harris VM, Sharma R, Cavett J, Kurien BT, Liu K, Koelsch KA, Rasmussen A, Radfar L, Lewis D, Stone DU, Kaufman CE, Li S, Segal B, Wallace DJ, Weisman MH, Venuturupalli S, Kelly JA, Alarcon-Riquelme ME, Pons-Estel B, Jonsson R, Lu X, Gottenberg JE, Anaya JM, Cunninghame-Graham DS, Huang AJW, Brennan MT, Hughes P, Alevizos I, Miceli-Richard C, Keystone EC, Bykerk VP, Hirschfield G, Xie G, Siminovitch KA, Ng WF, Nordmark G, Bucher SM, Eriksson P, Omdal R, Rhodus NL, Rischmueller M, Rohrer M, Wahren-Herlenius M, Witte T, Mariette X, Lessard CJ, Harley JB, Sivils KL, Scofield RH.
Clin Immunol. 2018 Feb;187:137-138. doi: 10.1016/j.clim.2017.11.012. Epub 2017 Dec 7.
PMID: 29195081 No abstract available.
Eligibility for clinical trials in primary Sjögren's syndrome: lessons from the UK Primary Sjögren's Syndrome Registry.
Oni C, Mitchell S, James K, Ng WF, Griffiths B, Hindmarsh V, Price E, Pease CT, Emery P, Lanyon P, Jones A, Bombardieri M, Sutcliffe N, Pitzalis C, Hunter J, Gupta M, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Barone F, Fisher B, Rauz S, Richards A, Bowman SJ.
Rheumatology (Oxford). 2017 Dec 1;56(12):2255. doi: 10.1093/rheumatology/kex331.
PMID: 28968900 Free PMC article. No abstract available.
Recommendations for collaborative paediatric research including biobanking in Europe: a Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative.
Kuemmerle-Deschner JB, Hansmann S, Wulffraat NM, Vastert SJ, Hens K, Anton J, Avcin T, Martini A, Koné-Paut I, Uziel Y, Ravelli A, Wouters C, Shaw D, Özen S, Eikelberg A, Prakken BJ, Ruperto N, Horneff G, Constantin T, Beresford MW, Sikken M, Foster HE, Haug I, Schuller S, Jägle C, Benseler SM.
Ann Rheum Dis. 2018 Mar;77(3):319-327. doi: 10.1136/annrheumdis-2017-211904. Epub 2017 Oct 11.
PMID: 29021237 Review.
Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.
Bezzina OM, Gallagher P, Mitchell S, Bowman SJ, Griffiths B, Hindmarsh V, Hargreaves B, Price EJ, Pease CT, Emery P, Lanyon P, Bombardieri M, Sutcliffe N, Pitzalis C, Hunter J, Gupta M, McLaren J, Cooper AM, Regan M, Giles IP, Isenberg DA, Saravanan V, Coady D, Dasgupta B, McHugh NJ, Young-Min SA, Moots RJ, Gendi N, Akil M, MacKay K, Ng WF, Robinson LJ; UK Primary Sjögren's Syndrome Registry.
Arthritis Care Res (Hoboken). 2017 Nov;69(11):1714-1723. doi: 10.1002/acr.23165. Epub 2017 Oct 9.
PMID: 27992710 Free PMC article.
The British Society for Rheumatology guideline for the management of adults with primary Sjögren's Syndrome.
Price EJ, Rauz S, Tappuni AR, Sutcliffe N, Hackett KL, Barone F, Granata G, Ng WF, Fisher BA, Bombardieri M, Astorri E, Empson B, Larkin G, Crampton B, Bowman SJ; British Society for Rheumatology Standards, Guideline and Audit Working Group.
Rheumatology (Oxford). 2017 Oct 1;56(10):1828. doi: 10.1093/rheumatology/kex375.
PMID: 28957572 No abstract available.
The British Society for Rheumatology guideline for the management of adults with primary Sjögren's Syndrome.
Price EJ, Rauz S, Tappuni AR, Sutcliffe N, Hackett KL, Barone F, Granata G, Ng WF, Fisher BA, Bombardieri M, Astorri E, Empson B, Larkin G, Crampton B, Bowman SJ; British Society for Rheumatology Standards, Guideline and Audit Working Group.
Rheumatology (Oxford). 2017 Oct 1;56(10):e24-e48. doi: 10.1093/rheumatology/kex166.
PMID: 28957550 No abstract available.
The British Society for Rheumatology guideline for the management of adults with primary Sjögren's Syndrome.
Price EJ, Rauz S, Tappuni AR, Sutcliffe N, Hackett KL, Barone F, Granata G, Ng WF, Fisher BA, Bombardieri M, Astorri E, Empson B, Larkin G, Crampton B, Bowman SJ; British Society for Rheumatology Standards, Guideline and Audit Working Group.
Rheumatology (Oxford). 2017 Oct 1;56(10):1643-1647. doi: 10.1093/rheumatology/kex163.
PMID: 28957549 No abstract available.
Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?
Jansen MAA, Spiering R, Broere F, van Laar JM, Isaacs JD, van Eden W, Hilkens CMU.
Immunology. 2018 Jan;153(1):51-59. doi: 10.1111/imm.12811. Epub 2017 Sep 18.
PMID: 28804903 Free PMC article. Review.
Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions.
Cowell J, Buck M, Essa AH, Clarke R, Vollmer W, Vollmer D, Hilkens CM, Isaacs JD, Hall MJ, Gray J.
Chembiochem. 2017 Sep 5;18(17):1688-1691. doi: 10.1002/cbic.201700214. Epub 2017 Jul 19.
PMID: 28581639 Free PMC article.
Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?
Hanusch BC, Tuck SP, McNally RJQ, Wu JJ, Prediger M, Walker J, Tang J, Piec I, Fraser WD, Datta HK, Francis RM.
Osteoporos Int. 2017 Oct;28(10):2877-2886. doi: 10.1007/s00198-017-4122-0. Epub 2017 Jul 6.
PMID: 28685278
Characterization of systemic disease in primary Sjögren's syndrome: EULAR-SS Task Force recommendations for articular, cutaneous, pulmonary and renal involvements.
Manuel RC, Pilar BZ, Raphaèle S, Hendrika B, Simon J B, Thomas D, Jacques-Eric G, Xavier M, Elke T, Stefano B, Salvatore V, Thomas M, Wan-Fai N, Aike K, Athanasios T, Claudio V; EULAR Sjögren Syndrome Task Force.
Rheumatology (Oxford). 2017 Jul 1;56(7):1245. doi: 10.1093/rheumatology/kex157.
PMID: 28379527 Free PMC article. No abstract available.
A new MHC-linked susceptibility locus for primary Sjögren's syndrome: MICA.
Carapito R, Gottenberg JE, Kotova I, Untrau M, Michel S, Naegely L, Aouadi I, Kwemou M, Paul N, Pichot A, Locke J, Bowman SJ, Griffiths B, Sivils KL, Sibilia J, Inoko H, Micelli-Richard C, Nocturne G, Ota M, Ng WF, Mariette X, Bahram S.
Hum Mol Genet. 2017 Jul 1;26(13):2565-2576. doi: 10.1093/hmg/ddx135.
PMID: 28379387 Free PMC article.
T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans.
Clifford T, Wood MJ, Stocks P, Howatson G, Stevenson EJ, Hilkens CMU.
Eur J Appl Physiol. 2017 Aug;117(8):1727-1737. doi: 10.1007/s00421-017-3667-0. Epub 2017 Jun 23.
PMID: 28646302 Free PMC article.
Transitional care for rheumatic conditions in Europe: current clinical practice and available resources.
Clemente D, Leon L, Foster H, Carmona L, Minden K.
Pediatr Rheumatol Online J. 2017 Jun 9;15(1):49. doi: 10.1186/s12969-017-0179-8.
PMID: 28599656 Free PMC article.
The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.
Smith SL, Plant D, Eyre S, Hyrich K, Morgan AW, Wilson AG, Isaacs JD, Barton A.
Rheumatology (Oxford). 2017 Jun 1;56(6):1019-1024. doi: 10.1093/rheumatology/kew387.
PMID: 28096457 Free PMC article.
Omics analysis of human bone to identify genes and molecular networks regulating skeletal remodeling in health and disease.
Reppe S, Datta HK, Gautvik KM.
Bone. 2017 Aug;101:88-95. doi: 10.1016/j.bone.2017.04.012. Epub 2017 Apr 24.
PMID: 28450214 Review.
An investigation into the prevalence of sleep disturbances in primary Sjögren's syndrome: a systematic review of the literature.
Hackett KL, Gotts ZM, Ellis J, Deary V, Rapley T, Ng WF, Newton JL, Deane KHO.
Rheumatology (Oxford). 2017 Apr 1;56(4):570-580. doi: 10.1093/rheumatology/kew443.
PMID: 28013207 Free PMC article. Review.
Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis.
Steinbusch MM, Fang Y, Milner PI, Clegg PD, Young DA, Welting TJ, Peffers MJ.
Sci Rep. 2017 Mar 2;7:43558. doi: 10.1038/srep43558.
PMID: 28252005 Free PMC article.
Modelling the molecular mechanisms of aging.
Mc Auley MT, Guimera AM, Hodgson D, Mcdonald N, Mooney KM, Morgan AE, Proctor CJ.
Biosci Rep. 2017 Feb 23;37(1):BSR20160177. doi: 10.1042/BSR20160177. Print 2017 Feb 28.
PMID: 28096317 Free PMC article. Review.
A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5.
Ratnayake M, Tselepi M, Bloxham R, Plöger F, Reynard LN, Loughlin J.
PLoS One. 2017 May 8;12(5):e0176523. doi: 10.1371/journal.pone.0176523. eCollection 2017.
PMID: 28481944 Free PMC article.
Physical activity but not sedentary activity is reduced in primary Sjögren's syndrome.
Ng WF, Miller A, Bowman SJ, Price EJ, Kitas GD, Pease C, Emery P, Lanyon P, Hunter J, Gupta M, Giles I, Isenberg D, McLaren J, Regan M, Cooper A, Young-Min SA, McHugh N, Vadivelu S, Moots RJ, Coady D, MacKay K, Dasgupta B, Sutcliffe N, Bombardieri M, Pitzalis C, Griffiths B, Mitchell S, Miyamoto ST, Trenell M; UK Primary Sjögren’s Syndrome Registry.
Rheumatol Int. 2017 Apr;37(4):623-631. doi: 10.1007/s00296-016-3637-6. Epub 2016 Dec 24.
PMID: 28013357 Free PMC article.
Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.
Chan CM, Macdonald CD, Litherland GJ, Wilkinson DJ, Skelton A, Europe-Finner GN, Rowan AD.
J Biol Chem. 2017 Feb 3;292(5):1625-1636. doi: 10.1074/jbc.M116.756601. Epub 2016 Dec 12.
PMID: 27956552 Free PMC article.
Let's not fool ourselves. In RA, the ACR/EULAR remission criteria are not perfect!
Baker KF, Pratt AG, Thompson B, Isaacs JD.
Ann Rheum Dis. 2017 Jun;76(6):e12. doi: 10.1136/annrheumdis-2016-210797. Epub 2016 Dec 1.
PMID: 27934680 No abstract available.
Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T cells partly via transforming growth factor-β1.
Anderson AE, Swan DJ, Wong OY, Buck M, Eltherington O, Harry RA, Patterson AM, Pratt AG, Reynolds G, Doran JP, Kirby JA, Isaacs JD, Hilkens CM.
Clin Exp Immunol. 2017 Jan;187(1):113-123. doi: 10.1111/cei.12870. Epub 2016 Nov 2.
PMID: 27667787 Free PMC article.
Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.
McGovern A, Schoenfelder S, Martin P, Massey J, Duffus K, Plant D, Yarwood A, Pratt AG, Anderson AE, Isaacs JD, Diboll J, Thalayasingam N, Ospelt C, Barton A, Worthington J, Fraser P, Eyre S, Orozco G.
Genome Biol. 2016 Nov 1;17(1):212. doi: 10.1186/s13059-016-1078-x.
PMID: 27799070 Free PMC article.
Mortality rates are increased in patients with systemic juvenile idiopathic arthritis.
Davies R, Southwood T, Kearsley-Fleet L, Lunt M, Baildam E, Beresford MW, Foster HE, Douglas S, Thomson W, De Cock D; BCRD Study Group; BSPAR-ETN Study Group, Hyrich KL.
Arch Dis Child. 2017 Feb;102(2):206-207. doi: 10.1136/archdischild-2016-311571. Epub 2016 Oct 31.
PMID: 27799155 No abstract available.
Use of structured musculoskeletal examination routines in undergraduate medical education and postgraduate clinical practice - a UK survey.
Baker KF, Jandial S, Thompson B, Walker D, Taylor K, Foster HE.
BMC Med Educ. 2016 Oct 21;16(1):277. doi: 10.1186/s12909-016-0799-6.
PMID: 27765034 Free PMC article.
A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells.
Peffers MJ, Collins J, Loughlin J, Proctor C, Clegg PD.
Stem Cell Res Ther. 2016 Sep 14;7(1):133. doi: 10.1186/s13287-016-0384-2.
PMID: 27624072 Free PMC article.
Clinical trials of biosimilars should become more similar.
Kay J, Isaacs JD.
Ann Rheum Dis. 2017 Jan;76(1):4-6. doi: 10.1136/annrheumdis-2015-208113. Epub 2016 Aug 25.
PMID: 27566795 No abstract available.
Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.
Jani M, Isaacs JD, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A.
Rheumatology (Oxford). 2016 Nov;55(11):2050-2055. doi: 10.1093/rheumatology/kew299. Epub 2016 Aug 25.
PMID: 27565176 Free PMC article.
Systematic review and critical appraisal of transitional care programmes in rheumatology.
Clemente D, Leon L, Foster H, Minden K, Carmona L.
Semin Arthritis Rheum. 2016 Dec;46(3):372-379. doi: 10.1016/j.semarthrit.2016.06.003. Epub 2016 Jun 9.
PMID: 27496195 Review.
Treatment prescribing patterns in patients with juvenile idiopathic arthritis (JIA): Analysis from the UK Childhood Arthritis Prospective Study (CAPS).
Davies R, Carrasco R, Foster HE, Baildam EM, Chieng SEA, Davidson JE, Ioannou Y, Wedderburn LR, Thomson W, Hyrich KL.
Semin Arthritis Rheum. 2016 Oct;46(2):190-195. doi: 10.1016/j.semarthrit.2016.06.001. Epub 2016 Jun 8.
PMID: 27422803 Free PMC article.
High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.
Jani M, Isaacs JD, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A; BRAGGSS.
Ann Rheum Dis. 2017 Jan;76(1):208-213. doi: 10.1136/annrheumdis-2015-208849. Epub 2016 May 31.
PMID: 27245864 Free PMC article.
Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia.
Pal D, Blair HJ, Elder A, Dormon K, Rennie KJ, Coleman DJ, Weiland J, Rankin KS, Filby A, Heidenreich O, Vormoor J.
Leukemia. 2016 Aug;30(8):1691-700. doi: 10.1038/leu.2016.79. Epub 2016 May 25.
PMID: 27109511 Free PMC article.
Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.
Bell GM, Anderson AE, Diboll J, Reece R, Eltherington O, Harry RA, Fouweather T, MacDonald C, Chadwick T, McColl E, Dunn J, Dickinson AM, Hilkens CM, Isaacs JD.
Ann Rheum Dis. 2017 Jan;76(1):227-234. doi: 10.1136/annrheumdis-2015-208456. Epub 2016 Apr 26.
PMID: 27117700 Free PMC article. Clinical Trial.
The first international workshop on the epigenetics of osteoarthritis.
Meulenbelt IM, Bhutani N, den Hollander W, Gay S, Oppermann U, Reynard LN, Skelton AJ, Young DA, Beier F, Loughlin J.
Connect Tissue Res. 2017 Jan;58(1):37-48. doi: 10.3109/03008207.2016.1168409. Epub 2016 Mar 30.
PMID: 27028588
Factors associated with choice of biologic among children with Juvenile Idiopathic Arthritis: results from two UK paediatric biologic registers.
Kearsley-Fleet L, Davies R, Baildam E, Beresford MW, Foster HE, Southwood TR, Thomson W, Hyrich KL.
Rheumatology (Oxford). 2016 Sep;55(9):1556-65. doi: 10.1093/rheumatology/kev429. Epub 2016 Jan 4.
PMID: 26732349 Free PMC article.
Effectiveness and safety of TNF inhibitors in adults with juvenile idiopathic arthritis.
Kearsley-Fleet L, McErlane F, Foster HE, Lunt M, Watson KD, Symmons DP, Hyrich KL.
RMD Open. 2016 Oct 7;2(2):e000273. doi: 10.1136/rmdopen-2016-000273. eCollection 2016.
PMID: 27843575 Free PMC article.
Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features.
García-González PA, Schinnerling K, Sepúlveda-Gutiérrez A, Maggi J, Hoyos L, Morales RA, Mehdi AM, Nel HJ, Soto L, Pesce B, Molina MC, Cuchacovich M, Larrondo ML, Neira Ó, Catalán DF, Hilkens CM, Thomas R, Verdugo RA, Aguillón JC.
Front Immunol. 2016 Oct 25;7:458. doi: 10.3389/fimmu.2016.00458. eCollection 2016.
PMID: 27826300 Free PMC article.
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4+ T Cells.
Maggi J, Schinnerling K, Pesce B, Hilkens CM, Catalán D, Aguillón JC.
Front Immunol. 2016 Sep 19;7:359. doi: 10.3389/fimmu.2016.00359. eCollection 2016.
PMID: 27698654 Free PMC article.
Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeq.
Peffers MJ, Goljanek-Whysall K, Collins J, Fang Y, Rushton M, Loughlin J, Proctor C, Clegg PD.
PLoS One. 2016 Aug 17;11(8):e0160517. doi: 10.1371/journal.pone.0160517. eCollection 2016.
PMID: 27533049 Free PMC article.
Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines.
Howard Tripp N, Tarn J, Natasari A, Gillespie C, Mitchell S, Hackett KL, Bowman SJ, Price E, Pease CT, Emery P, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg DA, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Lendrem DW, Ng WF.
RMD Open. 2016 Jul 19;2(2):e000282. doi: 10.1136/rmdopen-2016-000282. eCollection 2016.
PMID: 27493792 Free PMC article.
A concept mapping study evaluating the UK's first NHS generic fatigue clinic.
Hackett KL, Lambson RL, Strassheim V, Gotts Z, Deary V, Newton JL.
Health Expect. 2016 Oct;19(5):1138-49. doi: 10.1111/hex.12405. Epub 2015 Sep 1.
PMID: 26332418 Free PMC article.

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