In June 2013 we will host the third international workshop on Clinical Therapeutic Tolerance. The first, in June 2005 was entitled ‘Therapeutic Tolerance: Myth or Reality?’ In 2009 we entitled our workshop ‘Therapeutic Tolerance: Closer to Reality?’ For 2013 we have put together a further exciting programme, when we can start to discuss our attempts to induce and to measure therapeutic tolerance in the clinic. We have invited speakers from across the autoimmunity, transplantation and allergy fields and our provisional programme is attached.
THERAPEUTIC TOLERANCE: INDUCING STRATEGIES IN THE CLINIC
The Third Newcastle Therapeutic Tolerance Workshop
26th-28th June 2013, Newcastle upon Tyne
Wednesday 26th June – Research Beehive, Newcastle University
Wednesday morning – delegates arrive for registration
Session 1- Tolerance Mechanisms
Dan Littman (New York, USA) The Microbiome and Tolerance
Georg Holländer (Oxford, UK) Central Tolerance Mechanisms
Steve Cobbold (Oxford, UK) Peripheral Tolerance Mechanisms
Alan Mowatt (Glasgow, UK) Mucosal Tolerance Mechanisms
Session 2- Tolerance Mechanisms
Peter Krammer (Heidelberg, Germany) Apoptosis and therapeutic tolerance
Steve Anderton (Edinburgh, UK) Tolerance and autoimmunity – interrogating the players
Anne Cooke (Cambridge, UK) Tolerance breakdown in murine diabetes
Iain McInnes (Glasgow, UK) Investigating immune tolerance – a systems biology approach
Buffet dinner (Great North Museum)
Thursday 27th June – Research Beehive, Newcastle University
Session 3- Cells and the maintenance of tolerance
Ethan Shevach (Maryland, USA) Regulatory T Cells
Simon Fillatreau (Berlin, Germany) B Cells and tolerance
Herman Waldmann (Oxford, UK Cellular metabolism and tolerance
Chris Buckley (Birmingham, UK) The role of the stroma in immune tolerance
Matthew Collin (Newcastle, UK) Skin dendritic cells and graft versus host disease
Session 4 – Immune modulating strategies in the clinic
Lucienne Chatenoud (Paris, France) Anti-CD3 Therapy to Induce Tolerance
Joanna Jones (Cambridge, UK) Depletional tolerance in multiple sclerosis
Thomas Wekerke (Vienna, Austria) Costimulation blockade in man, mechanisms and outcomes
Michael Ehrenstein (London, UK) Manipulating cytokines to induce tolerance
Session 5 – Immune modulating strategies in the clinic
David Wraith (Bristol, UK) Peptide Induced Tolerance
Mark Larche (Ontario, Canada) Peptide therapy of allergy with a focus on response biomarkers
Berent Prakken (Utrecht Netherlands) Heat shock proteins and tolerance
Jacob van Laar (Newcastle, UK) Autologous stem cell transplantation
Sir Roy Calne (Cambridge, UK) Prope tolerance – how near can we get?
Dinner (The Life Centre)
Friday 28th June – Research Beehive, Newcastle University
Session 6 – Maximising clinical benefits of tolerogenic therapies
Andrew Mellor (Georgia, USA) Indoleamine dioxygenase and tolerance
Robert Lechler (London, UK) Biomarker of tolerance induction
Andrew Cope (London, UK) Can we define a true remission state in RA?
Alberto Sanchez-Fueyo (London, UK) Iron metabolism and transplantation tolerance
John Isaacs (Newcastle, UK) Getting the timing right
David Wofsy (California, USA) Designing a therapeutic tolerance trial
Session 7 – Tolerogenic dendritic cells
Ranjeny Thomas (Brisbane, Australia) Tolerogenic DCs in rheumatoid arthritis
Catharien Hilkens (Newcastle, UK) AuToDeCRA
Angus Thomson (Pittsburgh, USA) Tolerogenic dendritic cells in transplantation
Session 8 – Cellular Therapies
Kathryn Wood (Oxford, UK) Regulatory T cell in transplantation
Giovanna Lombardi (London, UK) Optimising therapy with regulatory T cells
David Klatzmann (Paris, France) Interleukin-2 and regulatory T cell expansion
Alan Tyndall (Basel, Switzerland) Mesenchymal Stem Cells – The Holy Grail
Abstract submission deadline 14th March 2013 For those wishing to submit a poster presentation, please provide a 350 word abstract (no more than 1 side of A4), with up to 1 figure or table and include subheadings (Objectives, Methods, Results, Discussion).
Abstracts should be sent to firstname.lastname@example.org (you will hear before the end of March whether your abstract has been accepted).
For further information please contact Lisa Tait (email@example.com).
Places are limited so please make sure you register soon to avoid disappointment.