Varied fare this Wednesday including osteoarthritis and physical exercise...
ICM Research Seminar
Speakers: Kile Green, (Prof M Collin, Dr V Bigley, Dr G Smith)
Rebecca Brown, (Prof J Mathers, Dr L Avery, Dr N O’Brien, Dr D Cuthbertson)
Dr Pawel Palmowski, (Prof M Taggrt, Prof N Europe-Finner, Dr A Treumann)
Venue: Dental Lecture Theatre F, Dental School
Date and Time: Wednesday 9th March 2016, 13.00 pm – 14.00 pm
Kile Green will discuss
‘Array-based gene signature generation and gene set reduction in human blood monocyte and dendritic cell subsets’
Gene expression microarray data is typically composed of far more variables than samples. A major issue with this data format is revealed when using the data for the classification of samples or in the prediction of a clinical outcome. The problem of 'small n, large p' may be addressed through gene selection and dimension reduction under the presumption that while there are a large number of genes in the dataset, only a small number of these may actually account for the majority of the sample variation.
Rebecca Brown will discuss
'The Impact of Vitamin D and Physical Activity on Older Obese people with Knee Osteoarthritis - a cross sectional study'
Dr Pawel Palmowski will discuss
‘Protein expression changes in heart development. Mass spectrometry based proteomics analysis of fetal and adult guinea pig ventricular muscle’
Over the past 10 years we can observe a rapid expansion of proteomics technologies into all branches of biological science. They have a potential to provide an in depth qualitative and quantitative characterisation of a biological system in terms of protein expression, post translational modifications and interactions. In our study we utilise proteomics tools to identify processes and pathways involved in the process of heart development/maturation
Chair: Dara O’Hogain