Monday 14 March 2016

An Osteoarthritis Special - Scaffolding, Mesenchymal Stem Cells and Gene Editing









ICM Research Seminar


Speakers: Dr David Almarza Gomez, (Prof J Loughlin)

Sylvia Muller (Dr Xiao Wang, Prof A Dickinson)


Venue: Dental Lecture Theatre F, Dental School

Date and Time:  Wednesday 16th March 2016, 13.00 pm – 14.00 pm


David Almarza Gomez will discuss


“Genome editing using CRISPR/Cas9 system to target OA risk loci”


Genome editing is a powerful tool to establish the functional and mechanistic roles of disease-associated single nucleotide polymorphisms (SNPs) mapped by genome wide association studies (GWASs). This project is intended to address causality of osteoarthritis (OA)-associated SNPs by generation of isogenic cell lines using CRISPR-Cas9 technology followed by phenotypic characterization. I will talk about my current work focussed on targeting OA risk loci with CRISPR-Cas9 system, as well as the establishment of a delivery system for genome editing substrates based on Integrase-defective lentiviral vectors.”


Sylvia Muller will discuss


'The effect of apatite-wollastonite glass ceramics on MSC growth, osteogenic differentiation and migration'


Apatite wollastonite (AW) is a bioactive glass ceramic used to produce osteoconductive scaffolds for bone repair. To produce high levels of integration and tissue regeneration scaffolds can be seeded with osteogenic precursors prior to implantation or be designed to recruit cells in from the surrounding tissues. In this study we investigate the osteogenic potency of CD271-enriched mesenchymal stromal cells (MSCs) and assess is AW scaffolds provide MSCs with any migratory stimulation


Chair: Nina Jordan







Toni Bell


Clerical Assistant

Institute of Cellular Medicine

4th Floor, William Leech Building | Newcastle University | Framlington Place | NE2 4HH


0191 208 5851




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