THERAPEUTIC
TOLERANCE: FIRST-IN-HUMAN DATA
27th - 30th
June 2017
Research
Beehive, Old Library Building,
Newcastle
University, Newcastle upon Tyne
DRAFT
PROGRAMME
Tuesday
27th June
12.00
|
Registration and
lunch
| |
13.30
|
Professor John
Isaacs
|
Welcome and
introduction
|
13.40
|
Keynote
speaker
Ron
Germain (NIH, USA)
|
Imaging the immune
system
|
Session 1- Cells and
Mechanisms
Chaired by John
Isaacs
| ||
14.30
|
Georg
Hollander
(Oxford, UK)
|
The
Thymus – a 2017 perspective
|
14.50
|
Ethan Shevach
(NIH, USA)
|
What’s the latest in
regulatory T-cells
|
15.10
|
Herman Waldmann
(Oxford, UK)
|
Novel antibodies
with improved properties
|
15.30
|
David Samson
(UCL,
UK)
|
What does CTLA4
really do?
|
15.50
|
Discussion
|
|
16.10
|
Coffee break
(Poster/exhibitor viewing)
|
|
Session 2 – Breaking Tolerance in
Cancer
Chaired by Andy
Mellor
| ||
16.30
|
Samir
Khleif
(Augusta, USA)
|
Rational
design for combination immunotherapy
|
16.50
|
Ted
Johnson
(Augusta, USA)
|
Trials
and tribulations in breaking tumour tolerance
|
17.10
|
Dario
Vignali (Pittsburgh,
USA)
|
Tolerance and
cancer
|
17.30
|
Robert Wilkinson
(Medimmune)
|
Immunological
targets to combat cancer
|
17.50
|
Discussion
|
|
19.00
(TBC)
|
Conference
dinner
|
Wednesday
28th June
Session 3 – New Concepts in
Tolerance
Chaired by
| ||||
08.30
|
Tea/coffee
|
|||
08.45
|
||||
09.05
|
Paul-Peter Tak
(Stevenage,
UK)
|
Immunomodulation by
vagal nerve stimulation
| ||
09.25
|
George
Kassiotis (CRICK,
UK)
|
Endogenous
retroviruses and the breakdown of immune
tolerance
| ||
09.45
|
Femke
van Wijk (Utrecht,
Netherlands)
|
Resetting
T-cell regulation in Juvenile Idiopathic
Arthritis
| ||
10.05
|
Ignacio
Anegnon (Nantes,
France)
|
Novel mechanisms in
tolerance induction
| ||
10.25
|
Discussion
|
|||
10.45
|
Coffee break
(Poster/exhibitor viewing)
|
|||
Session 4 – Short oral
presentations
Chaired by
| ||||
11.05
|
||||
11.20
|
||||
11.35
|
||||
11.50
|
||||
12.05
|
||||
12.20
|
Lunch
(Poster/exhibitor viewing)
| |||
Session 5 –
Tolerance Biomarkers in Autoimmune Disease
Chaired by
| ||
13.20
|
Maria
Hernandez-Fuentes
(KCL, UK)
|
Biomarkers
in transplantation tolerance
|
13.40
|
John Isaacs
(Newcastle, UK)
|
Update on the RA-MAP
consortium
|
14.00
|
Georg
Schett (Erlangen,
Germany)
|
Autoantibodies
as tolerance biomarkers
|
14.20
|
Helmut
Jonuleit (Mainz,
Germany)
|
Tolerogenic targets
in regulatory T-cells
|
14.40
|
Anish
Suri (Turnhoutseweg,
Belgium)
|
Parsing
the TCR repertoire in RA to enable tolerogenic
trials
|
15.00
|
Discussion
|
|
15.20
|
Coffee break
(poster/exhibitor viewing)
|
|
The Great Debate
(1)
Chaired by
|
||
15.40
|
Debate: Therapeutic
Tolerance: Pie-in-the-Sky or
Just-Around-the-Corner?
| |
16.40
|
Poster
session
| |
18.40
|
Close
| |
Thursday
29th June
Session 6 – Cellular
Therapies – first-in-human results
Chaired by
|
|||||
08.30
|
Tea/coffee
|
||||
08.45
|
Giovanna
Lombardi (KCL,
UK)
|
Tregs in kidney
transplantation – first-in-human data
| |||
09.05
|
Piotr
Trzonkowski (Gdansk,
Poland)
|
Tregs
therapies in type I diabetes
| |||
09.25
|
Maria Ester
Bernardo (Milan,
Italy)
|
Mesenchymal stem
cells for tolerance induction in human disease
| |||
09.45
|
Catharien
Hilkens (Newcastle,
UK)
|
AuToDeCRA
| |||
10.05
|
|||||
10.25
|
Discussion
|
||||
10.45
|
Coffee break
(Poster/exhibitor viewing)
|
||||
Session 7 -
Peptides
Chaired by
| |||||
11.05
|
David
Wraith
(Birmingham, UK)
|
Apitope
therapy in MS and other conditions
| |||
11.25
|
Mark
Peakman (KCL,
UK)
|
Peptide therapy in
diabetes
| |||
11.45
|
Kei
Kishimoto (Massachusetts,
USA)
|
Tolerogenic
nanoparticles
| |||
12.05
|
Ranjeny Thomas
(Brisbane,
Australia)
|
A platform for
peptide therapeutics
| |||
12.25
|
Willem van Eden
(Utrecht, the
Netherlands)
|
The enigma of heat
shock proteins in immune tolerance
| |||
12.45
|
Discussion
|
||||
13.05
|
Lunch
(Poster/exhibitor viewing)
| ||||
Session 8 –
Tolerogenic Antibody Therapy
Chaired by
| |||
14.05
|
Lucienne
Chatenoud
(Paris, France)
|
Anti-CD3
– an update
|
|
14.25
|
Alasdair Coles
(Cambridge, UK)
|
Alemtuzumab in
Multiple Sclerosis
|
|
14.45
|
Andy
Cope (KCL,
UK)
|
Treating
very early autoimmunity
|
|
15.05
|
Mike Ehrenstein
(UCL, UK)
|
Anti-TNF as a
tolerogenic therapy
|
|
15.25
|
|||
15.45
|
|||
16.05
|
Discussion
|
||
16.25
|
Coffee break
(Poster/exhibitor viewing)
|
The Great Debate
(2)
Chaired by
|
||
16.45
|
Debate:
| |
17.45
|
Close
| |
19.00
(ish)
|
Conference
dinner
| |
Friday
30th June
08.30
|
Tea/coffee
|
|
08.45
|
Keynote
speaker
Lars Klareskog
(Stockholm,
Sweden)
|
Evolution of an
autoimmune disease – a window of opportunity for tolerance
induction?
|
Session 9 –
Metabolism and Metabolomics
Chaired by
|
|||||
09.35
|
Andy
Mellor
(Newcastle, UK)
|
IDO
and tolerance – where are we now?
| |||
09.55
|
Hozefa
Bandukwala (Massachusetts,
USA)
|
Anti-anabolic drugs
and immunosuppression
| |||
10.15
|
Duncan
Howie (Oxford,
UK)
|
How
FoxP3 regulates immune metabolism
| |||
10.35
|
|||||
10.55
|
Discussion
|
||||
11.15
|
Coffee break
(Poster/exhibitor viewing)
|
||||
Session 10 –
Immunotherapeutics
Chaired by
| |||||
11.35
|
Jaap
van Laar
(Utrecht, Netherlands)
|
Hematologic
transplantation as a therapy for autoimmunity
| |||
11.55
|
Andreas
Radbruch
(Berlin, Germany)
|
Restoring
B cell tolerance
| |||
12.15
|
Michelle
Rosenzwajg (Paris,
France)
|
Low dose IL-2
therapy
| |||
12.35
|
Luis
Graca (Lisbon,
Portugal)
|
Tolerance
to Factor VIII
| |||
12.55
|
Claudia
Mauri (London,
UK)
|
Regulatory
B Cells
| |||
13.05
|
Discussion
|
||||
13.25
|
Closing remarks and
poster prizes (lunch)
|
||||
Coming Soon - June 2017
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