PI Seminar Series
Speaker: Dr Bart Everts, Leiden Immunoparasitology Group, Leiden University Medical Center
Venue: Baddiley Clark Seminar Room
Date: Monday 6th March 2017
Dr Bart Everts will present:
'Metabolic control of dendritic cell-driven immune polarization'
Dendritic cells (DCs) play a crucial role in the regulation of adaptive immune responses by governing the activation and maintenance of different CD4+ T helper subsets and CD8+ cytotoxic T cell responses. As such, there is great interest in developing approaches to target and manipulate these cells for immunotherapy. Over the last 5 years it has become increasingly clear that immune cell activation, proliferation, fate and function are closely linked to, and dependent on activation of specific metabolic pathways. This has led to the emerging concept that manipulation of immune cell metabolism could be a powerful and attractive approach to direct immune responses. Evidence is accumulating that cellular metabolism also plays a key role in DC biology. I will here discuss our most recent findings in this field of DC metabolism, with particular focus on the crucial roles for particular metabolic pathways in DCs that underpin their ability to prime and polarize different T cell responses.
Chair: Professor Muzz Haniffa