Tuesday 21 October 2014

Variety: Sinusitis, fibrosis, inflammation, Bioinformatics, sensor, Clostridium difficile, Eczema, Filaggrin, Methotrexate




Institute Research Student Seminars

Speakers:  Stephen Ball, Beth Lawry & Martina Elias


Venue: Seminar room L2.5, 2nd floor, William Leech Building, Medical School

Date and time:  Wednesday 22nd October 2014 at 12.30


Stephen Ball will present:

“Epithelial – Fibroblast interactions in the pathogenesis of chronic rhinosinusitis”


Chronic rhinosinusitis (CRS) is one of our commonest health conditions, affecting up to 12.5% of adults, is the fifth commonest antibiotic prescription and incurs $5.8billion in direct health costs.  Maximal medical therapy (antibiotics/steroids) has high failure rates and as a result 1 in 4 patients undergo surgery, though this is not surprising given the pathogenesis of CRS is not known.  Here we are investigating the roles of the epithelium & fibroblasts in the persistent inflammatory processes.


Key words: Sinusitis, fibrosis, inflammation


Beth Lawry will discuss:

Characterising Unique Detection Biomarkers for Clostridium difficile”


Using a novel bioinformatics system, unique Clostridium difficile biomarkers were identified and confirmed with laboratory techniques. Antibodies against these markers will be integrated into a detection sensor.


Key words: Bioinformatics, sensor, Clostridium difficile


Martina Elias will speak on:

Mechanistic insights into methotrexate efficacy in eczema”


Null mutations in the key epidermal protein, Filaggrin, strongly predispose the development of Atopic Eczema (AE). Methotrexate is an effective therapeutic option; however, its precise mechanism of action in AE is unknown. We have shown MTX acts directly on keratinocytes to promote epidermal differentiation, lipid accumulation and improved barrier function in a thymidine dependent manner. A detailed understanding of these mechanisms may ultimately reveal novel therapeutic targets for the treatment of AE and other disorders of keratinisation.


Keywords: Eczema, Filaggrin, Methotrexate


Chair:  Sophie Cassidy





No comments:

Post a Comment

Note: only a member of this blog may post a comment.