Wednesday 6 April 2016

Varied Fare Today: Chemokines, Protease Inhibitors and Cardiac Monitoring


ICM Research Seminar

Speakers: Beatriz Martinez Burgo (Prof S Ali, Prof J Kirby, Prof N Sheerin)
Dr David Wilkinson (Prof D Rowan)
Nduka Okwose (Prof M Trenell, Dr D Jakovljevic, Dr D Houghton)

Venue: Dental Lecture Theatre F, Dental School
Date and Time: Wednesday 6th April 2016, 13.00 pm – 14.00 pm

Beatriz Martinez Burgo will discuss:

"Chemokine function modulation in the Acute Inflammatory Response: Implications in IRI after Transplantation"

Transplantation is currently the most efficient therapy for treating organ failure. However, one of its major limitations is early-stage inflammation, such as Ischemia-Reperfusion Injury (IRI), which results in increased production of chemokines, and also reactive species that can modify the chemokine function. In particular, CXCL1 and CXCL8 are critical inflammatory mediators in neutrophil migration in a range of surgeries, e.g. kidney transplantation. Understanding chemokine structure-function modulation, how to detect it, and also how to target this modulation may be key for more efficient therapeutic development.


Dr David Wilkinson will discuss:

“Investigating the role of endogenous serine protease inhibitors in cartilage biology”

Cartilage degradation is of critical importance in arthritic disease. Serine proteases are key enzymes involved in the proteolytic cascades leading to cartilage breakdown. Here, the role of endogenous serine protease inhibitors (serpins) is investigated in the context of Cartilage Biology.


Nduka Okwose will discuss:

“Evaluation of non-invasive cardiac function monitoring devices and their feasibility for cardiac rehabilitation”

A presentation of data from a validity study comparing Inert gas re-breathing and Bioreactance techniques for measuring cardiac output.


Chair: David Swan





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