ICM Guest Seminar, Wednesday 27 November 2013

 

Institute Research Seminar

 

Guest speaker: Dr Arian Laurence

[National Institute of Arthritis and Musculoskeletal & Skin Diseases, NIH, USA]

 

Venue: Seminar room L2.6, 2^nd floor, Leech Building, Medical School

Date and time:  Wednesday 27 November 2013 at 12.00 noon

 

Dr Laurence will discuss:

 

"Epithelial and haematopoetic STAT3 is required for antibacterial defence

in a mouse model of HIES."

 

Autosomal dominant Hyper IgE syndrome is an immunodeficiency associated with mutations in STAT3. To dissect the importance of STAT3 in haematopoietic and non-haematopoietic cells we generated a mouse model of this disease. These animals recapitulate multiple aspects of HIES including susceptibility to bacterial infections that was only partially corrected by bone marrow transplantation, emphasising the role played by the epithelium in the pathophysiology of HIES.

 

 

Key words:  HIES (Hyper Ig E syndrome), IL-17, IL-22, STAT3

 

_______________________

 

Arian is a UK-trained haematologist and current postdoctoral member of John O'Shea's group at NIH, working on the role of STAT3 and STAT5 signaling in T cells.  He will be in Newcastle all day on the 27^th - please contact Sophie Hambleton (sophie.hambleton@ncl.ac.uk) if you would like an opportunity to talk with him.

 

Chair:  Dr Sophie Hambleton