Institute Research Seminar
Guest speaker: Dr Arian Laurence
[National Institute of Arthritis and Musculoskeletal & Skin Diseases, NIH, USA]
Venue: Seminar room L2.6, 2nd floor, Leech Building, Medical School
Date and time: Wednesday 27 November 2013 at 12.00 noon
Dr Laurence will discuss:
"Epithelial and haematopoetic STAT3 is required for antibacterial defence
in a mouse model of HIES."
Autosomal dominant Hyper IgE syndrome is an immunodeficiency associated with mutations in STAT3. To dissect the importance of STAT3 in haematopoietic and non-haematopoietic cells we generated a mouse model of this disease. These animals recapitulate multiple aspects of HIES including susceptibility to bacterial infections that was only partially corrected by bone marrow transplantation, emphasising the role played by the epithelium in the pathophysiology of HIES.
Key words: HIES (Hyper Ig E syndrome), IL-17, IL-22, STAT3
Arian is a UK-trained haematologist and current postdoctoral member of John O'Shea's group at NIH, working on the role of STAT3 and STAT5 signaling in T cells. He will be in Newcastle all day on the 27th - please contact Sophie Hambleton (firstname.lastname@example.org) if you would like an opportunity to talk with him.
Chair: Dr Sophie Hambleton