Tuesday 26 November 2013

ICM Guest Seminar, Wednesday 27 November 2013


Institute Research Seminar


Guest speaker: Dr Arian Laurence

[National Institute of Arthritis and Musculoskeletal & Skin Diseases, NIH, USA]


Venue: Seminar room L2.6, 2nd floor, Leech Building, Medical School

Date and time:  Wednesday 27 November 2013 at 12.00 noon


Dr Laurence will discuss:


"Epithelial and haematopoetic STAT3 is required for antibacterial defence

in a mouse model of HIES."


Autosomal dominant Hyper IgE syndrome is an immunodeficiency associated with mutations in STAT3. To dissect the importance of STAT3 in haematopoietic and non-haematopoietic cells we generated a mouse model of this disease. These animals recapitulate multiple aspects of HIES including susceptibility to bacterial infections that was only partially corrected by bone marrow transplantation, emphasising the role played by the epithelium in the pathophysiology of HIES.



Key words:  HIES (Hyper Ig E syndrome), IL-17, IL-22, STAT3




Arian is a UK-trained haematologist and current postdoctoral member of John O'Shea's group at NIH, working on the role of STAT3 and STAT5 signaling in T cells.  He will be in Newcastle all day on the 27th - please contact Sophie Hambleton (sophie.hambleton@ncl.ac.uk) if you would like an opportunity to talk with him.


Chair:  Dr Sophie Hambleton




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