ICM Research Seminar, Wednesday 4 December 2013, 1.00pm

 

Institute Research Student Seminars

Speakers: PhD students Paul Milne (Haematology), Christopher Fox (Transplantation) and Emma Woodward (Dermatology)

Venue: Seminar room L2.5, 2^nd floor, Leech Building, Medical School

Date and time:  Wednesday 4 December 2013 at 1.00pm

 

Paul Milne will present:

 

"Total Mononuclear Cell Profiling in Haematological Malignancies."

 

The development of multi-parameter flow cytometry protocols to completely define the mononuclear cellular components of haematological malignancies and immunodeficiencies.

 

Key words:  Leukaemia, Mononuclear Cells, Flow Cytometry

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Christopher Fox will talk about:

 

"Screening of Cathepsin B and D expression in an apoptotic acute model of kidney IRI."

 

The project aims to investigate if the cathepsin B or D play a role in apoptosis during renal ischemia reperfusion injury (IRI). Following IRI the kidney undergoes 4 phases of regeneration, with apoptosis and necrosis as first stage.  In this study we screened the expression of cathepsins along different ischemic times in order to assess if cathepsins expression correlates with the rate of apoptosis in a mouse model of IRI.

 

Key words:  Kidney, Cathepsin, Apoptosis, Ischemia reperfusion injury

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Emma Woodward will discuss:

 

"Investigating the pathogenesis of chloracne."

 

To understand the role of cathepsins and autophagy in regulating epidermal homeostasis

and toxicity following AhR activation by dioxin in skin.

 

Key words: Autophagy, Cathepsin D, Aryl hydrocarbon receptor

 

Chair:  Sadaf Atarod, PhD student (Haematology)