Monday 24 March 2014

Tissue Engineering Special: Wednesday 26th March 2014




Institute Research Student Seminars

Speakers:  Sylvia Muller, PhD student (Haematology), Simon Partridge, PhD student (Musculoskeletal) and Shane Walsh, PhD student (Musculoskeletal)


Venue: Seminar room L2.3, 2nd floor, Leech Building, Medical School

Date and time:  Wednesday 26 March 2014 at 1.00pm


Sylvia Muller will present:


"A study of Mesenchymal stem cells for arthritis repair".


CD271 is thought to be a marker of precursor Mesenchymal stem cells (MSCs), which have a fast rate of expansion and a strong propensity for osteogenic differentiation. This project aims to assess the use of CD271 derived MSC populations in scaffold based bone regeneration.


Key words: Mesenchymal stem cells, osteoarthritis, tissue scaffolds.


Simon Partridge will discuss:


"Hydroxyapatite nanoparticles: Bone and cartilage tissue engineering".

How hydroxyapatite is produced artificially and how specific parameters can influence hydroxyapatite nano-crystal morphology and composition. How surface coating of hydroxyapatite on degradable polymeric surfaces influences cell behaviour. Incorporating ceramic nano-particles with polymeric materials. Materials have been evaluated using human mesenchymal stem cells.


Key words:  Bone, tissue engineering, mesenchymal stem cell


Shane Walsh will speak on:


"Novel surfaces to stimulate and influence mesenchymal stem cell activity"


This project will employ the use of thin polymer films to identify favourable polymer topographies and exploit different polymer chemistries to functionalize surfaces with biomolecules. Investigating the restricted immobilisation of biomolecules to discrete regions of the surfaces, studies quantify the biological activity retained at the surface by evaluating mesenchymal stem cell (MSC) morphology and gene expression. These studies will help define parameters in scaffold development for musculoskeletal repair.

Keywords: mesenchymal stem cells; polymer; crosslinking

Chair:  Teresa Kelly, PhD student (Reproductive & Vascular Biology)








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