July 3rd, Tessa Crompton, Hedgehog Signalling in T-Cell Differentiation

Thursday 3rd July

Professor Tessa Crompton

"Hedgehog signalling in T cell differentiation"

Please note that due to refurbishment work, Tessa's seminar will take place at 5pm in Lecture theatre G.05 in the Percy Building (opposite the Beehive Building)

For further information re. Tessa's research interests please see her website at:

http://www.ucl.ac.uk/flarre/people/crompton-tessa

Tissue-derived hedgehog proteins modulate Th differentiation and disease.

Furmanski AL, Saldana JI, Ono M, Sahni H, Paschalidis N, D'Acquisto F, Crompton T.

J Immunol. 2013 Mar 15;190(6):2641-9. doi: 10.4049/jimmunol.1202541. Epub 2013 Feb 13.

T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss.

Furmanski AL, O'Shaughnessy RF, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG, Crompton T.

J Invest Dermatol. 2013 May;133(5):1221-30. doi: 10.1038/jid.2012.492. Epub 2013 Jan 10.

Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog.

Lau CI, Outram SV, Saldaña JI, Furmanski AL, Dessens JT, Crompton T.

Blood. 2012 May 17;119(20):4741-51. doi: 10.1182/blood-2011-10-387266. Epub 2012 Mar 28.

Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte.

Furmanski AL, Saldana JI, Rowbotham NJ, Ross SE, Crompton T.

Eur J Immunol. 2012 Feb;42(2):489-99. doi: 10.1002/eji.201141758. Epub 2011 Dec 16.

CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response?

D'Acquisto F, Crompton T.

Biochem Pharmacol. 2011 Aug 15;82(4):333-40. doi: 10.1016/j.bcp.2011.05.019. Epub 2011 May 27. Review.

Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.

Drakopoulou E, Outram SV, Rowbotham NJ, Ross SE, Furmanski AL, Saldana JI, Hager-Theodorides AL, Crompton T.

Cell Cycle. 2010 Oct 15;9(20):4144-52. Epub 2010 Oct 27.

Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells.

Maione F, Paschalidis N, Iqbal AJ, Crompton T, Perretti M, D'Acquisto F.

Autoimmunity. 2010 Dec;43(8):672-81. doi: 10.3109/08916931003678296. Epub 2010 Apr 7.

Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection.

Paschalidis N, Huggins A, Rowbotham NJ, Furmanski AL, Crompton T, Flower RJ, Perretti M, D'Acquisto F.

Cell Cycle. 2010 Feb 15;9(4):784-93. Epub 2010 Feb 17.

Peptide-specific, TCR-alpha-driven, coreceptor-independent negative selection in TCR alpha-chain transgenic mice.

Furmanski AL, Bartok I, Chai JG, Singh Y, Ferreira C, Scott D, Holland SJ, Bourdeaux C, Crompton T, Dyson J.

J Immunol. 2010 Jan 15;184(2):650-7. doi: 10.4049/jimmunol.0902291. Epub 2009 Dec 7.

Shh, BMP4 and IL-7 in the maintenance and differentiation of human CD34+ progenitor cells in the thymus.

Furmanski AL, Crompton T.

Cell Cycle. 2009 Dec;8(23):3810. Epub 2009 Dec 1. No abstract available.

The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms.

Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Rowbotham NJ, Crompton T.

J Immunol. 2009 Sep 1;183(5):3023-32. doi: 10.4049/jimmunol.0900152. Epub 2009 Aug 10.

Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism.

Rowbotham NJ, Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Dessens JT, Crompton T.

Blood. 2009 May 21;113(21):5144-56. doi: 10.1182/blood-2008-10-185751. Epub 2009 Mar 9.

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.

Outram SV, Hager-Theodorides AL, Shah DK, Rowbotham NJ, Drakopoulou E, Ross SE, Lanske B, Dessens JT, Crompton T.

Blood. 2009 Mar 5;113(10):2217-28. doi: 10.1182/blood-2008-03-144840. Epub 2008 Dec 23.

KLF13 influences multiple stages of both B and T cell development.

Outram SV, Gordon AR, Hager-Theodorides AL, Metcalfe J, Crompton T, Kemp P.

Cell Cycle. 2008 Jul 1;7(13):2047-55. Epub 2008 May 5.

Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation.

Rowbotham NJ, Furmanski AL, Hager-Theodorides AL, Ross SE, Drakopoulou E, Koufaris C, Outram SV, Crompton T.

Cell Cycle. 2008 Apr 1;7(7):904-8. Epub 2008 Jan 18.