Cell Signalling and Immune Response Regulation

We are very pleased to announce that this month's guest is Dr Simon Arthur  from the College of Life Sciences, University of Dundee.  http://www.lifesci.dundee.ac.uk/people/simon-arthur

 

Simon will be giving a presentation entitled: "Intra-cellular signalling pathways in the regulation of immune responses"

 

5pm next Thursday, September 18th 2014 in room 2.21, Research Beehive, Newcastle University (Refreshments will be available from 4.30 pm).

 

The interests of the Arthur laboratory lie in signalling networks that control inflammation, with a  particular focus on the roles that cells of the innate immune system play in coordinating inflammation and how they contribute to activation of adaptive immunity via the production of cytokines.

 

 

If you would like to speak to Simon during his visit please contact Graeme O'Boyle: Graeme.O'Boyle@sunderland.ac.uk

 

 

 

 

Some of Simons' recent publications can be found here:

 

Transcriptional regulation of IL-10 and its cell-specific role in vivo. 2014  Crit Rev Immunol. MacKenzie KF, Pattison MJ, Arthur JS. http://www.ncbi.nlm.nih.gov/pubmed/24941159

 

 

The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One. 2014 Poncet N, Mitchell FE, Ibrahim AF, McGuire VA, English G, Arthur JS, Shi YB, Taylor PM. http://www.ncbi.nlm.nih.gov/pubmed/24586861

 

 

CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling. 2014 Biochem J.  Naqvi S, Martin KJ1, Arthur JS. http://www.ncbi.nlm.nih.gov/pubmed/24438093

 

 

Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell. 2013 Castor D, Nair N, Déclais AC, Lachaud C, Toth R, Macartney TJ, Lilley DM, Arthur JS, Rouse J. http://www.ncbi.nlm.nih.gov/pubmed/24076219

 

 

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A. 2013  Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D, Cohen P. http://www.ncbi.nlm.nih.gov/pubmed/23986494

 

 

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol. 2013 McGuire VA, Gray A, Monk CE, Santos SG, Lee K, Aubareda A, Crowe J, Ronkina N, Schwermann J, Batty IH, Leslie NR, Dean JL, O'Keefe SJ, Boothby M, Gaestel M, Arthur JS. http://www.ncbi.nlm.nih.gov/pubmed/23979601

 

 

Mitogen-activated protein kinases in innate immunity. 2013 Nat Rev Immunol Arthur JS, Ley SC. http://www.ncbi.nlm.nih.gov/pubmed/23954936

 

 

 

Dr Rachel Harry