ICM PI Seminar 7th July - Pharmacogenetics & Liver Disease

 

 

PI Seminar Series

 

Speaker: Professor Ann Daly, Professor of Pharmacogenetics

 

Venue: Lecture Theatre C, Dental School

 

Time and Date: 7^th July 2015 13.00-14.00

 

Professor Ann Daly will present:

 

'GENETIC RISK FACTORS FOR DRUG-INDUCED LIVER INJURY'

 

 

Drug-induced liver injury (DILI) is a rare but serious problem with certain widely prescribed drugs and can result in liver failure. It is also a relatively common cause of drug attrition during development. Progress on identifying genetic risk factors for DILI due to a range of drugs using genome-wide association studies will be considered. The genetic associations we have seen, involving both HLA and non-HLA genes, provide new insights into the underlying mechanisms for idiosyncratic DILI and may assist in the development of improved strategies for its prediction and diagnosis.

 

Chair: Dr Quentin Anstee