ICM Research Seminar
Speakers: Marco Silipo (Dr A. Tyson-Capper, Dr H. Gautrey)
Dr Kenneth Hodson (Prof R. Taylor, Prof S. Robson,
Dr V. Araujo-Soares)
Venue: Dental Lecture Theatre F, Dental School
Date and Time: Wednesday 18th May 2016, 13.00 pm – 14.00 pm
Marco Silipo will discuss:
"Defining regulation of the HER2 splice variant Herstatin in breast cancer cell lines."
This project focuses on the human epidermal growth factor receptor 2 (HER2) which is over-expressed in 30% of breast tumours (HER2+) l. Although several therapies target HER2, patients often acquire drug resistance. Alternative splicing of HER2 gene generates a functional distinct variant (Herstatin) which arises from inclusion of intron 8. Herstatin acts as tumour suppressor by effectively blocking HER2 activity and cell proliferation. The aim of this project is to define the factors that regulate the alternative splicing of Herstatin.
Dr Kenneth Hodson will discuss:
WELLBABE: WEight Loss Looking for Baby and Mother’s Better Outcomes – A Pilot Study of Dietary Intervention for the Treatment of Gestational Diabetes Mellitus
This project uses magnetic resonance techniques to define the physiology of insulin resistance in pregnancy and the pathophysiology of gestational diabetes, a poorly understood condition affecting 5% of women and contributing to worse obstetric outcomes. We explore the metabolic effect of a reduced calorie diet (1,200kcal/day), a controversial treatment in pregnancy, on liver fat content and glycaemic control. This is the first in vivo study of liver fat in human pregnancy and will inform future metabolic and clinical studies.