Wednesday 16 October 2019

Synovial Fibroblasts


Faculty Seminar



Kirsten Klein

Centre of Experimental Rheumatology, University Hospital Zurich







Thursday 17th October 2019



11.30 – 12.30


Kirsten will present:


"Epigenetics of synovial fibroblasts"


Synovial fibroblasts are the most abundant stromal cells in joints that promote inflammation and drive joint destruction in rheumatoid arthritis. Synovial fibroblasts from different joint localizations exhibit profound differences in their expression profiles, which translate into a joint specific enrichment of arthritis relevant pathways, molecules and functional differences. Epigenetic factors act as intermediaries to link genetic and environmental risk factors to altered gene expression levels in a cell type-specific manner. Epigenetic mechanisms define the positional identity of synovial fibroblasts and underlie their role in persistent inflammation. Interfering with epigenetic modifications and their related epigenetic enzymes have therapeutic potential in rheumatoid arthritis.



Professor John Isaacs








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