Fibroblast Double Bill: More Details Wednesday 22 January 2014, 1.00pm

 

 

Institute Research Student Seminars

Speakers:  Nicola Green, PhD student (Transplantation) and

Rachel Williams, PhD student (Oral & Dental Sciences)

 

 

Venue: Seminar room L2.5, 2^nd floor, Leech Building, Medical School

Date and time:  Wednesday 22 January 2014 at 1.00pm

 

 

Nicola Green will present:

 

"Fibroblasts as possible pro-inflammatory modulators in COPD".

 

This work evaluates the release of alarmins from lung epithelial cells in response to a variety of insults including oxidative stress, ER stress and viral infection and  their impact on lung fibroblast responses.  This is assessed in both primary "normal" lung cells and diseased primary cells extracted from explanted lung tissue from patients undergoing lung transplantaion for end stage COPD.

 

 

Key words:  COPD and Fibroblasts

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Rachel Williams will discuss:

 

"Leptin-mediated MMP-1 production in gingival fibroblasts requires MAPK signalling".

 

Gingival fibroblasts secrete matrix metalloproteinases (MMPs) in response to inflammatory signals. I have previously shown that the adipokine leptin can regulate MMP production by primary human gingival fibroblasts, and this talk will discuss an intracellular mechanism that regulates this effect.

 

 

Key words: fibroblasts, inflammation, adipokines

 

Chair:  Darren Johnson, PhD student (Dermatology)