Tuesday 21 January 2014

Fibroblast Double Bill: More Details Wednesday 22 January 2014, 1.00pm



Institute Research Student Seminars

Speakers:  Nicola Green, PhD student (Transplantation) and

Rachel Williams, PhD student (Oral & Dental Sciences)



Venue: Seminar room L2.5, 2nd floor, Leech Building, Medical School

Date and time:  Wednesday 22 January 2014 at 1.00pm



Nicola Green will present:


"Fibroblasts as possible pro-inflammatory modulators in COPD".


This work evaluates the release of alarmins from lung epithelial cells in response to a variety of insults including oxidative stress, ER stress and viral infection and  their impact on lung fibroblast responses.  This is assessed in both primary "normal" lung cells and diseased primary cells extracted from explanted lung tissue from patients undergoing lung transplantaion for end stage COPD.



Key words:  COPD and Fibroblasts



Rachel Williams will discuss:


"Leptin-mediated MMP-1 production in gingival fibroblasts requires MAPK signalling".


Gingival fibroblasts secrete matrix metalloproteinases (MMPs) in response to inflammatory signals. I have previously shown that the adipokine leptin can regulate MMP production by primary human gingival fibroblasts, and this talk will discuss an intracellular mechanism that regulates this effect.



Key words: fibroblasts, inflammation, adipokines


Chair:  Darren Johnson, PhD student (Dermatology)







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