Tuesday 18 February 2014

COPD and Menorrhagia Double Billing




Institute Research Student Seminars

Speakers:  Jodie Birch, PhD student (Transplantation)

and Sourima Shivhare, PhD student (Reproductive & Vascular Biology)


Venue: Seminar room L2.5, 2nd floor, Leech Building, Medical School

Date and time:  Wednesday 19 February at 1.00pm


Jodie Birch will present:


“Ageing Airways: Contributions to COPD?”


Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition caused by cigarette smoking. Accelerated lung ageing and cellular senescence are believed to contribute to COPD pathogenesis. Airway epithelial cells (AECs) line the airways of the lung and likely encounter numerous senescence-inducing insults. We have investigated the expression of a number of senescence-associated markers in the small and large AECs of patients with COPD and also evaluated telomere length and the presence of DNA damage foci at telomeres.


Key words:  COPD, airways, senescence, telomeres




Sourima Shivhare will speak on:


“Menstrual cycle distribution of uterine natural killer cells is altered in Menorrhagia”.


Menorrhagia affects 30% of women, is the reason for >50% hysterectomies and significantly interferes with quality of life. Altered endometrial vascular maturation is seen in menorrhagia and recurrent miscarriage, the latter with increased uterine natural killer (uNK) cells. This study compared endometrial leukocyte populations in controls and women with menorrhagia.


Keywords: Menorrhagia, uNKs, leukocyte



Chair:  Helen Lawrence, PhD student (Reproductive & Vascular Biology)










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