Thursday 19 February 2015

B Cells, T Cells, RA and Immunity

The next Immunology North East Seminar is at 5pm on Thursday 5th March 2014.  The seminar will be held in the Research Beehive Rm 2.21, Newcastle University and refreshments will be available from 4.30pm.  



Dr. Tom Barr, Institute of Infection, Immunity and Inflammation, University of Glasgow will present


“T follicular helper cells: Heterogeneity in phenotype and function”?




If you would like to speak to Tom during his visit please contact Dr Andy Knight


More information on Tom's research can be found at:


Brief Interests: I study B cells, the under appreciated workhorse of the immune system. These cells produce the antibodies that protect us from infection following vaccination but can also cause autoimmune disorders, such as rheumatoid arthritis. While recent research has focused on antibody production by B cells, I believe that their role in autoimmune disorders is much more complex -- so the fundamental question governing my work is “how else can B cells influence immunity?"


Recent publications (with pubmed web link):


Leech, M. D., Barr, T., Turner, D.G., Brown, S., O'Connor, R.A., Gray, D., Mellanby, R.J., and Anderton, S.M. (2013) Cutting edge: IL-6-dependent autoimmune disease: dendritic cells as a sufficient, but transient, source. Journal of Immunology, 190(3). pp. 881-885. (doi:10.4049/jimmunol.1202925)


Barr, T.A. et al. (2012) B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells. Journal of Experimental Medicine, 209(5). pp. 1001-1010. (doi:10.1084/jem.20111675)


Barr, T.A., Gray, M., and Gray, D. (2012) B cells: programmers of CD4 T cell responses. Infectious Disorders - Drug Targets, 12(3). pp. 222-231. (doi:10.2174/187152612800564446)


Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., MacDonald, A.S., Mutapi, F., and Zamoyska, R. (2012) Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE, 7(4). e35466. (doi:10.1371/journal.pone.0035466)


van der Vlugt, L.E.P.M. et al. (2012) Schistosomes induce regulatory features in human and mouse CD1dhi B Cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS ONE, 7(2). e30883. (doi:10.1371/journal.pone.0030883)


Phythian-Adams, A.T. et al. (2010) CD11c depletion severely disrupts Th2 induction and development in vivo. Journal of Experimental Medicine, 207(10). pp. 2089-2096. (doi:10.1084/jem.20100734)


Barr, T.A., Brown, S., Mastroeni, P., and Gray, D. (2010) TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica. Journal of Immunology, 185(5). pp. 2783-2789. (doi:10.4049/jimmunol.1001431)


Morrison, V.L., Barr, T.A., Brown, S., and Gray, D. (2010) TLR-mediated loss of CD62L focuses B cell traffic to the spleen during Salmonella typhimurium infection. Journal of Immunology, 185(5). pp. 2737-2746. (doi:10.4049/jimmunol.1000758)


Wilson, M.S., Taylor, M.D., O'Gorman, M.T., Balic, A., Barr, T.A., Filbey, K., Anderton, S.M., and Maizels, R.M. (2010) Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. European Journal of Immunology, 40(6). pp. 1682-1696. (doi:10.1002/eji.200939721)


Barr, T.A., Krembuszewski, M., Gupta, M., Gray, D., and Mareque-Rivas, J.C. (2010) Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models. Molecular BioSystems, 6(9). pp. 1572-1575. (doi:10.1039/c002066d)


Talbot, S., Totemeyer, S., Yamamoto, M., Akira, S., Hughes, K., Gray, D., Barr, T., Mastroeni, P., Maskell, D.J., and Bryant, C.E. (2009) Toll-like receptor 4 signalling through MyD88 is essential to controlSalmonella entericaserovar Typhimurium infection, but not for the initiation of bacterial clearance. Immunology, 128(4). pp. 472-483. (doi:10.1111/j.1365-2567.2009.03146.x)


Miles, K., Clarke, D.J., Lu, W., Sibinska, Z., Beaumont, P.E., Davidson, D.J., Barr, T.A., Campopiano, D.J., and Gray, M. (2009) Dying and necrotic neutrophils are anti-inflammatory secondary to the release of α-defensins. Journal of Immunology, 183(3). pp. 2122-2132. (doi:10.4049/jimmunol.0804187)


Barr, T.A., Brown, S., Mastroeni, P., and Gray, D. (2009) B cell intrinsic myD88 signals drive IFN- production from T cells and control switching to IgG2c. Journal of Immunology, 183(2). pp. 1005-1012. (doi:10.4049/jimmunol.0803706)


Foster, G.L. et al. (2008) Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88. Immunology, 124(4). pp. 469-479. (doi:10.1111/j.1365-2567.2007.02798.x)


Gray, D., Gray, M., and Barr, T. (2007) Innate responses of B cells. European Journal of Immunology, 37(12). pp. 3304-3310. (doi:10.1002/eji.200737728)


Barr, T.A., Brown, S., Ryan, G., Zhao, J., and Gray, D. (2007) TLR-mediated stimulation of APC: distinct cytokine responses of B cells and dendritic cells. European Journal of Immunology, 37(11). pp. 3040-3053. (doi:10.1002/eji.200636483) 


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