ICM Research Seminar
Speakers: Carlos Echevarria, PhD student (John Simpson)
Hannah Sinclair, PhD student (Vijay Kunadian)
and Ahmed Khudhur, PhD Student (Helen Foster)
Venue: Seminar room L2.5, Second floor, Leech Building, Medical School
Date and time: Wednesday 18th February 2015, 12:30
Carlos Echevarria will present:
“The DECAF score predicts acute mortality in acute exacerbations of COPD (AECOPD)”
We have developed and validated a prognostic score that can risk stratify patients with acute exacerbations of COPD into different mortality risk groups, using data that is routinely collected at admission. The DECAF score may be used to guide patient management, for example by identifying low risk patients suitable for Hospital at Home treatment.
Key words: Prognosis, mortality, COPD
Hannah Sinclair will discuss:
"New Insights into The Pattern Of Coronary Artery Disease In Frail Older Patients With Acute Coronary Syndrome"
Acute coronary syndrome (ACS) in older patients is common, with high morbidity and mortality and there is an increase in the use of contemporary invasive treatments such as percutaneous coronary intervention in this age group. It is known that frailty is common in older patients with ACS and frailty is an independent predictor of risk of adverse outcomes. However, it is not clear what the pathophysiology of this is. In younger patients it has been shown that "vulnerable" atherosclerotic plaques, i.e. those at risk of rupture, are associated with an increased risk of adverse cardiovascular events after an ACS. This study aims to investigate whether the higher rate of adverse outcomes in older patients with ACS is due to an increased prevalence of vulnerable plaque in the coronary arteries, and whether frailty is associated with higher vulnerable plaque burden.
Keywords: Acute coronary syndrome, intracoronary imaging, ageing
Ahmed Khudhur will speak on:
"Identification and Characterisation of Novel Salivary Biomarkers for Oral Inflammatory Disease"
Biomarkers are biological substances which can be measured objectively and used as indicators for number of activities in the human body which could be normal biological, pathological, or pharmacological responses to therapy. Saliva contains both locally and systemically derived biomarkers for many oral and systemic diseases. Saliva can provide the basis for the diagnosis and monitoring of periodontitis, dental caries, oral squamous cell carcinoma, oral lichen planus, cardiovascular diseases and many other diseases.
Keywords: Biomarkers, Saliva, Periodontitis
Chair: Sophie Cassidy, PhD student