ICM Research Seminar
Speakers: Irene Del Molinio Del Barrio, (Prof Kirby, Prof Ali, Dr A Meeson)
Dr Emma Fairhall, (Prof M Wright)
Katie Hackett (Prof F Ng)
Venue: Dental Lecture Theatre F, Dental School
Date and Time: Wednesday 10th February 2016, 13.00 pm – 14.00 pm
Irene Del Molinio Del Barrio
“CXCR4 and CXCR7 homodimers and heterodimers play differential roles in breast cancer”
Most breast cancer deaths are due to metastasis, a process mediated by the chemokine receptor CXCR4 and its ligand CXCL12. This process, however, may also be affected by the expression of CXCR7. Given CXCR7’s ability to form heterodimers with CXCR4, we investigated how dual expression of both receptors differed from their lone expression in terms of their signalling and internalization pathways.
Dr Emma Fairhall
“Transdifferentiation of pancreas to liver: a source of human hepatocyte-like cells.”
The B-13 cell line, is a rat pancreatic acinar cell line capable of transdifferentiating into functional hepatocyte-like cells through single glucocorticoid hormone exposure. Following work on the B-13 cells we aimed to identify an equivalent human cell line and investigate its conversion into hepatocyte-like cells in order to provide a more clinically relevant in vitro model.
“Identifying key barriers to participation for people with primary Sjogren’s syndrome in order to develop future psychosocial interventions: A group concept mapping study”.
Many people with primary Sjögren’s syndrome (PSS) experience difficulty participating fully in everyday activities such as work or leisure activities. The specific barriers to participating fully in daily life in this patient group are not yet understood. I am trying to identify priority participatory barriers for people with PSS. In the seminar, I will describe the theory of a group concept mapping exercise, and how this revealed key barriers which include fatigue, worry, sleep problems, pain and low mood. These will inform future interventions for PSS patients.
Chair: Eyman Rashdan