Wednesday, 24 February 2016

ICM Research Seminar Wednesday 24th February 2016 13.00pm Dental Lecture Theatre F

 Today's ICM Research Seminar Wednesday 24th February 2016 13.00pm Dental Lecture Theatre F

 

 

 

 

 

 

 

 

 

ICM Research Seminar

 

Speakers: Fouzeyyah Ali Alsaeedi, (Prof L Armstrong, Prof M Wright)

Ahmed Ghanim Mahdi Alhelal, (Prof J Whitworth)

Dr Karin Englehardt, (Prof S Hambleton)

 

Venue: Dental Lecture Theatre F, Dental School

Date and Time:  Wednesday 24th February 2016, 13.00 pm – 14.00 pm

 

Fouzeyyah Ali Alsaeedi

Potentiating stem cell-derived hepatocyte function

 

Utilising pluripotent stem cells (iPSCs), pancreatic and liver progenitor cells as a source of stem cell and investigate individually and in combination the effects of infecting the cells with viruses encoding liver specific transcription factors and the role of glucocorticoids and SGK1 expression on quantitative function of derived hepatocytes.

 

Ahmed Ghanim Mahdi Alhelal

Cell-systems physiology in the dental pulp - a preclinical investigation

 

Structural and functional interrelationships between odontoblast (OCL) and sub-odontoblast cell layers (SOCL) are relevant to tissue formation and regulation in health and disease, but are incompletely understood.  This study employed contemporary immunohistochemical , ELIZA and gene expression techniques to gain important new insights on tissue complexity and signalling within the rodent mandibular incisor.

 

Dr Karin Engelhardt

A novel heterozygous CD45 wedge mutation in a family with autoimmunity

We apply whole exome sequencing to identify pathogenic variants in novel or known disease-causing genes in patients with primary immunodeficiencies. Homozygous loss-of-function mutations in the gene PTPRC encoding the tyrosine phosphatase CD45, a critical regulator of lymphocyte signalling, are known to cause severe combined immunodeficiency (SCID). We found a novel heterozygous variant in PTPRC in a family with autoimmune features and aim to understand how this mutation in the wedge domain of CD45 leads to autoimmunity

 

 

Chair: Luigi Locatelli

 

 

 

 

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