Tuesday 4 November 2014

Arthritis, HER2 and Atrial Fibrillation: Tomorrow : 12:30





Institute Research Student Seminars

Speakers:  Nishanthi Thalayasingam, Anna-Lena Dittrich

& Sarah Anne Kane


Venue: Seminar room L2.5, 2nd floor, William Leech Building, Medical School

Date and time:  Wednesday 5th November 2014 at 12.30


Nishanthi Thalayasingam will present:


"A microarray analysis of peripheral blood B cells from early arthritis patients"


In Rheumatoid Arthritis (RA) chronic inflammation leads to joint damage and so it is vital treatment is commenced promptly to prevent this. There is increasing interest in the role of B cells in the pathogenesis of RA following the effectiveness of selective B cell depletion. The purpose of this project is to identify potential diagnostic biomarkers by comparing the gene expression profiles of B cells from newly diagnosed RA patients to that of patients diagnosed with other types of arthritis.

Key words: Rheumatoid Arthritis, microarray, B cells


Anna-Lena Dittrich will discuss:


"HER2: Regulation of alternative splicing and novel splice variants"


With more than 11000 deaths annually in the UK from breast cancer much effort has been made to provide optimal treatment. Our focus is on HER2, a proto-oncogene in breast cancer. Different splice variants of HER2 can have positive or negative effects on disease progression and therapy efficiency. Our aim is to identify additional splice variant and to understand the regulatory mechanisms underlying the alternative splicing.

Key words: Alternative splicing, ErbB2, Breast Cancer​


Sarah Anne Kane will speak on:


"The Detection of Atrial Fibrillation During 24-hour Blood Pressure Measurement"


Atrial Fibrillation (AF) is a cardiac arrhythmia that affects around 2% of the population. Early detection allows patients to begin potentially life-saving therapies so a simple, effective method for screening is required. One method is the use of modified blood pressure monitors that can pick up AF through incorporated pulse detection algorithms. In this project we aim to take this one step further and determine if it is feasible to screen for AF during 24 hour blood pressure measurements.

Keywords: Blood Pressure, Atrial Fibrillation, Clinical Trial


Chair:  Sophie Cassidy








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