Institute Research Student Seminars
Speaker: John Widdrington
Date and time: Wednesday 12th November 2014 at 12.30
John Widdrington will discuss:
"The effect of mtDNA depletion on immune functions in THP-1 cells"
Adverse outcomes in sepsis have been associated with both impaired immunity and depletion of mitochondrial DNA (mtDNA) in monocytes. This study assesses the link between these findings by determining the effects of depleting mtDNA copy number on the ability of THP-1 cells to produce immune responses to inflammatory stimuli.
Keywords: mitochondria, immunity, monocytic cells
Chair: Sadaf Atarod