Friday, 28 November 2014

Immunology and the Ageing B-Cell

The Immunology North East December meeting will take place on Thursday 11th December at 5pm (refreshments from 4.30pm) in the Research Beehive, Newcastle University room 2.21.   

 

Dr. Deborah Dunn-Walters, Division of Immunology, Infection and Inflammatory Disease; Chair of Mechanisms of Ageing section of Ageing Research At King's (ARK), King’s College London, will present  a talk entitled,

 

"The ageing B cell repertoire"

 

 

 

Research Interests

We have extensive experience in B cell repertoire analysis, and molecular events involving the immunoglobulin gene during B cell development. We combine traditional molecular biology techniques with novel mathematical analyses to devise new ways of investigating the humoral immune system.

Our particular interest is in research into ageing. Loss of immune system function with age results in the phenomenon termed “Immunosenescence.” This is associated with increased infectious disease morbidity and mortality, poor responses to vaccination, declines in established protective immunity, and increased incidence of autoimmune disorders. Until recently, most age-associated immune failures had been attributed to changes in T cell populations. However, there are many other changes in the immune system and, as data accumulate to show that B cells have a critical role in antigen presentation and regulation - in addition to their role as antibody producers - B cells and humoral immunity becomes highly significant.

More details on Deborah’s research can be found at http://www.kcl.ac.uk/lsm/research/divisions/diiid/departments/immunobiology/research/DunnWalters/index.aspx

 

Recent Publications:

Immunoglobulin gene repertoire diversification and selection in the stomach - from gastritis to gastric lymphomas.

Michaeli M, Tabibian-Keissar H, Schiby G, Shahaf G, Pickman Y, Hazanov L, Rosenblatt K, Dunn-Walters DK, Barshack I, Mehr R. Front Immunol. 2014 Jun 3;5:264. doi: 10.3389/fimmu.2014.00264. eCollection 2014.

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.

Immunogenetics and transplantation.

Davenport MP, Dunn-Walters DK. Curr Opin Immunol. 2013 Oct;25(5):606-7. doi: 10.1016/j.coi.2013.09.001. Epub 2013 Sep 26. No abstract available.

Human lymphocyte repertoires in ageing.

Boyd SD, Liu Y, Wang C, Martin V, Dunn-Walters DK. Curr Opin Immunol. 2013 Aug;25(4):511-5. doi: 10.1016/j.coi.2013.07.007. Epub 2013 Aug 28. Review.

BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome.

Pickman Y, Dunn-Walters D, Mehr R. Phys Biol. 2013 Oct;10(5):056001. doi: 10.1088/1478-3975/10/5/056001. Epub 2013 Aug 22.

Yersinia enterocolitica provides the link between thyroid-stimulating antibodies and their germline counterparts in Graves' disease.

Hargreaves CE, Grasso M, Hampe CS, Stenkova A, Atkinson S, Joshua GW, Wren BW, Buckle AM, Dunn-Walters D, Banga JP. J Immunol. 2013 Jun 1;190(11):5373-81. doi: 10.4049/jimmunol.1203412. Epub 2013 Apr 29.

Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis.

Freeley SJ, Coughlan AM, Popat RJ, Dunn-Walters DK, Robson MG. Ann Rheum Dis. 2013 Jun;72(6):1053-8. doi: 10.1136/annrheumdis-2012-202160. Epub 2012 Oct 19.

A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient.

Hoogeboom R, Wormhoudt TA, Schipperus MR, Langerak AW, Dunn-Walters DK, Guikema JE, Bende RJ, van Noesel CJ. Leukemia. 2013 Mar;27(3):738-40. doi: 10.1038/leu.2012.238. Epub 2012 Aug 20. No abstract available.

Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination.

Wu YC, Kipling D, Dunn-Walters DK. Front Immunol. 2012 Jul 9;3:193. doi: 10.3389/fimmu.2012.00193. eCollection 2012.

B cell immunosenescence: different features of naive and memory B cells in elderly.

Buffa S, Bulati M, PellicanĂ² M, Dunn-Walters DK, Wu YC, Candore G, Vitello S, Caruso C, Colonna-Romano G. Biogerontology. 2011 Oct;12(5):473-83. doi: 10.1007/s10522-011-9353-4. Epub 2011 Aug 31.

Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages.

Ademokun A, Wu YC, Martin V, Mitra R, Sack U, Baxendale H, Kipling D, Dunn-Walters DK. Aging Cell. 2011 Dec;10(6):922-30. doi: 10.1111/j.1474-9726.2011.00732.x. Epub 2011 Aug 10.

The relationship between CD27 negative and positive B cell populations in human peripheral blood.

Wu YC, Kipling D, Dunn-Walters DK. Front Immunol. 2011 Dec 26;2:81. doi: 10.3389/fimmu.2011.00081. eCollection 2011.

B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans.

Bulati M, Buffa S, Candore G, Caruso C, Dunn-Walters DK, PellicanĂ² M, Wu YC, Colonna Romano G. Ageing Res Rev. 2011 Apr;10(2):274-84. doi: 10.1016/j.arr.2010.12.002. Epub 2010 Dec 23. Review.

B cell repertoire and ageing.

Dunn-Walters DK, Ademokun AA. Curr Opin Immunol. 2010 Aug;22(4):514-20. doi: 10.1016/j.coi.2010.04.009. Epub 2010 May 25. Review.

 

 

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