Institute Research Student Seminars
Speakers: Eleana Pappa, Emma Rogers & Keith Wu
Date and time: Wednesday 26th November 2014 at 12.30
Eleana Pappa will present:
“Transcriptional and Phenotypic Characterization of Hepatic Stellate Cells”
(Derek Mann: Fibrosis Group)
Correlation of liver stiffness with fibrosis progression has been observed in many liver diseases. Hepatic stellate cells (HSC) are the main scaring forming cells in liver fibrosis. Activation of HSC from quiescent to myofibroblasts is the initial step for fibrosis development. In this project we evaluate the importance of substrate stiffness as driving force for HSC activation.
Key words: Liver fibrosis, Hydrogels, HSC
Emma Rogers will discuss:
“'A functional genetic study of the osteoarthritis-associated SNP rs4836732'”
(John Loughlin: Osteoarthritis Research Group)
A recent genome wide association scan identified the region defined by the intronic SNP rs4836732 to be associated with female hip osteoarthritis. This project intends to identify the functional SNP within this region and investigate how the SNP is mediating increased osteoarthritis susceptibility.
Key words: Osteoarthritis, genetics, SNP
Keith Wu will speak on:
“The Role of Epigenetics, including BET bromodomains, in the Control of Inflammatory Skin Disease”
(Nick Reynolds: Dermatology Group)
Psoriasis is a common inflammatory skin disease, often with systemic involvement, affecting up to 3% of the adult population. Despite its prevalence there is an unmet need for new therapies and the pathophysiology is not fully understood. Here we discuss the role of BET bromodomains in the control of inflammatory cytokines and their potential as a novel therapeutic target.
Key words: epigenetics, inflammation, therapeutics
Chair: Irene del Molino del Barrio