Check it Out: http://ard.bmj.com/cgi/content/full/annrheumdis-2013-204962
Conclusions Our data for the first time identifies a role for ubiquitination and the proteasome in the induction of OA via regulation of inflammatory mediator-induced MMP13 expression. These data open avenues of research to determine whether the proteasome, or K48-linked ubiquitination, are potential therapeutic targets in OA.
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